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Introduction: Acute intermittent porphyria is a disease inherited in an autosomal dominant manner, occurring with a frequency of 1:75,000 people. The main symptom of the disease is paroxysmal, colicky abdominal pain, which is accompanied by neuropsychiatric symptoms. For some patients, psychiatric symptoms are the only symptom of the disease. In this paper, the case of a 43-year-old patient struggling with recurrent colicky abdominal pain and depressive and anxiety disorders, which intensify during exacerbation periods, is presented, featuring an ambiguous diagnosis of porphyria in previous laboratory tests. In the treatment, glucose infusions, morphine, psychiatric and psychological therapy were used - saline solution was administered as a placebo. Aim: The aim of this paper is to highlight the difficulties in diagnosing psychiatric symptoms during an acute attack of porphyria, which significantly complicate its treatment, and to consider the possibility of using placebo as one of the elements in the diagnostic and therapeutic plan in order to optimize treatment and avoid complications by using smaller doses of narcotic drugs. Review methods: A thorough analysis of research studies available on PUBMED was conducted using the following keywords: acute intermittent porphyria; porphobilinogen; depression; anxiety disorders; psychiatry; placebo. The medical history of a 43-year-old female patient, suspected of having acute intermittent porphyria due to recurrent abdominal pain and psychiatric symptoms, was also analyzed. Conclusion: Our case illustrates how psychiatric symptoms can complicate the diagnosis of acute intermittent porphyria. Failing to recognize acute porphyria also carries the risk of life-threatening complications and may lead to unnecessary pharmacotherapy and stigmatization as a mental illness. This case demonstrates that placebo can be one of the components of a diagnostic and therapeutic plan of acute intermittent porphyria.

Introduction Pancreatic cancer is one of the most aggressive cancers. It occurs in men more often than women. The primary therapy for these cancers is surgery; chemotherapy, radiation therapy, hormone therapy, or immunotherapy are also used. More and better treatments are being sought for this disease. The use of PARP inhibitors in the treatment of pancreatic cancer has shown good results, so in this article we have done a review of the results of various studies on this topic. In this review, the results of studies on the use of various PARP inhibitors in pancreatic cancer of different hormonal status are presented. Purpose This article aims to give you an overview of the trials that have looked at the effects of different PARP inhibitors in the treatment of pancreatic cancer. PARP inhibitors are a relatively new cancer therapy with good results, so it is important to pay attention. State of Knowledge In this article, I used the PubMed database and considered papers from the last 10 years, but most of the information in this review comes from papers published after 2020. I have also taken into account the recommendations of the FDA and the European Medicines Agency on the use of PARP inhibitors. Conclusions PARP inhibitors have shown significant effects on pancreatic cancer outcomes. The differences in outcomes depending on the type of cancer, the PARP inhibitor used, and the previous therapies used in a given patient tell us how important it is to individualize therapy in oncology. The findings of the studies presented in this review also point to the need for further research that could focus on identifying patients who may best benefit from treatment with PARP inhibitors, as well as studying synergistic effects in combination with other forms of therapy, such as immunotherapy or chemotherapy. The changes in treatment outcomes that these drugs can bring underscore the importance of exploring new therapeutic strategies in oncology.

Introduction: Caffeine, a well-known stimulant, is commonly used by athletes to enhance performance across various sports, including combat sports. Its ergogenic properties, such as improved strength, endurance, and cognitive function, have been well documented in the literature. This paper explores the effects of caffeine supplementation on combat sports, specifically in disciplines such as judo, jiu-jitsu, taekwondo, and boxing. The impact of different doses of caffeine on performance in these sports is examined, along with potential risks, limitations, and considerations for its use. Aim of Study: The primary aim of this study is to analyze the effects of caffeine on performance in combat sports, considering various factors such as optimal dosage, timing, and the impact of habitual caffeine consumption. Additionally, this paper evaluates the potential adverse effects, including anxiety, sleep disturbances, and cardiovascular concerns, as well as the considerations regarding caffeine’s status as a banned substance in sports. Material and methods: A review of the literature on caffeine and its effect was performed using the PubMed database. Results and Conclusions: Caffeine supplementation consistently enhances performance in combat sports. Doses ranging from 3–6 mg/kg were found to improve strength, endurance, and reaction times across various combat sports, with higher doses being more effective for elite athletes. However, habitual caffeine consumption may diminish responsiveness to caffeine’s ergogenic effects. Caffeine’s potential adverse effects, such as anxiety, insomnia, and increased heart rate, were reported, with gender differences in sensitivity. While caffeine’s ergogenic effects are well-established, its use should be personalized, considering individual responses and training status. Furthermore, caffeine's legal status and potential interactions with other substances, such as alcohol and medications, must be considered in competitive settings.

Introduction: Intermittent fasting (IF) has emerged as a popular dietary intervention for its potential health benefits, including weight management, metabolic improvement, and reduced risk of chronic diseases. The practice alternates periods of eating and fasting, influencing physiological processes and offering an alternative to traditional calorie-restrictive diets. Purpose of Work: This paper aims to investigate the efficacy of IF as a revolutionary approach to maintaining health and mitigating the risks associated with chronic diseases. By analyzing contemporary research, the paper seeks to elucidate the underlying mechanisms and broader health implications of IF. State of Knowledge: Existing studies suggest that IF positively affects metabolic markers, enhances insulin sensitivity, and promotes autophagy—a cellular repair mechanism crucial for longevity and disease prevention. Emerging evidence links IF to improved cardiovascular health, reduced inflammation, and enhanced cognitive functions. However, variability in outcomes due to age, gender, and fasting protocols highlights the need for tailored approaches and further research. Material and methods: The research methodology entailed establishing the study aims, undertaking a systematic review of the literature, and implementing a structured process to screen pertinent studies. The investigation involved a comprehensive search across scientific databases, including PubMed and Google Scholar. Summary: Intermittent fasting represents a transformative paradigm in health and nutrition science. While preliminary findings are promising, more robust longitudinal studies are required to establish standardized protocols and validate its therapeutic potential across diverse populations. This paper underscores the promise of IF as a strategic tool in the prevention and management of chronic diseases.

Introduction: Hepatitis B remains a significant clinical issue. Despite the availability of effective vaccines, the world is still not free from this problem. Chronic hepatitis B virus (HBV) infection affects approximately 296 million people worldwide and is the leading cause of cirrhosis and liver cancer globally. HBV-related cirrhosis resulted in an estimated 331,000 deaths in 2019, and it is estimated that the number of deaths from HBV-related liver cancer in 2019 was 192,000, an increase from 156,000 in 2010. The rate of vaccination is particularly unsatisfactory in low-income countries, but even in high-income countries, the issue of hepatitis B has not been completely eradicated. Aim of the study: The aim of this paper is primarily to systematize knowledge regarding the natural course of HBV infection and therapeutic options for chronic hepatitis B, both in adults and children. It also aims to highlight the principles of monitoring pharmacotherapy. The paper also describes therapeutic possibilities in special cases, such as pregnancy, liver transplantation, and the initiation of immunosuppressive therapy. Attention is also given to the potential adverse effects of pharmacotherapy. Conclusions: As hepatitis B infection continues to pose a significant global health challenge and remains the leading cause of liver cirrhosis and hepatocellular carcinoma, it is essential to review the available treatment options for this condition. Even in Europe, where vaccination coverage has reached high levels, cases of hepatitis B are still detected, often incidentally. This review aims to provide an in-depth analysis of therapeutic approaches for chronic hepatitis B, considering factors such as patient age, clinical status, and liver fibrosis stage. Additionally, it emphasizes the importance of monitoring treatment efficacy and safety, while also addressing the potential adverse effects associated with antiviral therapy.

Introduction and Objective. Every year, 20 million people are diagnosed with cancer, most of whom undergo chemotherapy at some stage of treatment. Chemotherapy is associated with various side effects, with hair loss being one of the most visible and socially stigmatizing. This study aimed to evaluate and summarize existing strategies for preventing chemotherapy-induced hair loss. Review methods. Data for this paper were gathered using electronic databases like PubMed and Google Scholar, with a focus on papers from the last five years, particularly clinical trials, double-blind randomized studies, meta-analyses, and reviews. State of Knowledge. Around 65% of chemotherapy patients experience hair loss. Currently, the FDA has approved one method for preventing chemotherapy-induced alopecia (CIA): scalp cooling. This technique induces localized vasoconstriction, reducing the penetration of chemotherapy drugs into hair follicles. Scalp cooling is generally well-tolerated. Other potential methods include scalp injections of autologous platelet-rich plasma, which contains growth factors and anti-inflammatory cytokines, and microneedling, an invasive procedure with uncertain effectiveness, especially as a standalone treatment, that aims to stimulate angiogenesis. Conclusions. Effective, reliable methods for preventing chemotherapy-induced alopecia (CIA) are still lacking. A holistic approach to oncology care is needed to address the diverse needs of patients. Discovering new preventive methods would greatly improve patients' ability to cope with cancer treatment. However, most current approaches show only moderate efficacy or are still in clinical trials.

Introduction: Cardiovascular diseases remain the leading cause of morbidity and premature mortality. Even though the prevalence of cigarette smoking has decreased over the last few decades, it is still one of the most important preventable risk factors for cardiovascular diseases. Moreover, recently, an increasing number of people have been transitioning to e-cigarettes, which also influence blood pressure and the cardiovascular system. Purpose of the study: The following review analyzes the association between cigarette smoking and both prevalence and development of cardiovascular diseases. It also suggests the management of tobacco addiction. Materials and methods: A literature review of English language papers was conducted to summarize the latest knowledge on the topic, focusing on the most recent papers. The review was conducted using the PubMed database, with 53 works used and accessed before December 2024. Conclusions: Tobacco significantly affects the cardiovascular system, with numerous studies highlighting the negative impacts of both active and passive smoking. Although extensive knowledge exists about tobacco smoke's impact on the cardiovascular system, further research is still needed. A better understanding of the link between smoking and the development of cardiovascular diseases, as well as methods for the management of the addiction, is crucial to developing successful treatment and prevention strategies.

Introduction Global sugar consumption remains at alarmingly high levels, far exceeding World Health Organization recommendations. This raises the question of whether sweeteners, as low-sugar substitutes, can become a key solution to help people switch to healthier alternatives. WHO guidelines suggest limiting free sugars to less than 10% of daily energy intake, with further benefits for reducing it to below 5%. Such changes can improve overall health and reduce the risk of obesity, diabetes, cardiovascular diseases, and cancer. Among many sugar substitutes, aspartame is one of the most widely used synthetic sweeteners. Purpose The purpose of this article is to review the health effects of aspartame, focusing on its safety, cancer risk, impact on metabolism, obesity, diabetes, and other long-term effects. This paper aims to present scientific evidence on aspartame’s safety, including studies supporting its use and those raising concerns. It also discusses potential risks, especially for individuals with phenylketonuria, and provides expert recommendations for its consumption. Conclusion Aspartame, a widely used sugar substitute, has caused controversy due to concerns about its long-term health effects, such as potential cancer and neurodegenerative risks. However, most health organizations consider aspartame safe when consumed in moderation. Despite some studies linking it to health issues, there is insufficient evidence to confirm these risks in humans. People with phenylketonuria should avoid aspartame, but for most, it is safe within recommended daily intake limits. Materials and methods: Our review is based on an analysis of material collected in 'Pubmed', 'Google Scholar' and other scientific articles using the keywords: aspartame, aspartame safety, aspartame controversy.

This review explores the complex interactions between birth control pills and thyroid function, emphasizing the potential for misinterpreted thyroid test results and the risks associated with inappropriate treatment. Birth control pills, widely used for contraception, influence thyroid hormone binding proteins, leading to altered thyroid function test results that may mimic thyroid dysfunction. This can result in unnecessary levothyroxine prescriptions, with significant health implications. Additionally, the paper examines historical and recent perspectives on the relationship between hormonal contraceptives and hypothyroidism, highlighting a shift from a perceived risk to evidence of protective effects. Practical recommendations for healthcare providers, including the prioritization of TSH and FT3 measurements, aim to improve diagnostic accuracy and patient outcomes. This synthesis of evidence underscores the importance of informed clinical decision-making in managing thyroid health for individuals using oral contraceptives.

Introduction and Purpose: Drug poisoning among children and adolescents is an increasing public health issue worldwide and in Poland. Intentional poisonings, especially suicide attempts, are on the rise, often involving over-the-counter (OTC) medications, with paracetamol being the most commonly used substance. This paper aims to analyze the prevalence, characteristics, and implications of drug poisonings in youth, focusing on social and mental health factors, particularly during the COVID-19 pandemic. Materials and Methods: The study is based on retrospective data collected from Polish cities published between 2014 and 2023, examining hospital admissions, demographic trends, and poisoning agents. Results: The study reveals a significant increase in suicide attempts, especially during the COVID-19 pandemic. Paracetamol poisoning remains the leading cause of intentional overdoses, with severe cases potentially resulting in acute liver failure or death if untreated. Girls account for a disproportionate number of cases, and many adolescents who attempt suicide lack prior psychiatric diagnoses. Seasonal trends and shifts in age demographics suggest changing patterns in poisoning incidents. Conclusions: The findings emphasize the need for improved mental health education, early intervention, and caregiver awareness. Strengthening psychological support and implementing stricter regulation of OTC drugs are crucial to addressing the root causes of youth suicide attempts. Proactive measures, such as teaching problem-solving skills and expanding access to mental health services, are essential to mitigating this growing public health challenge.

Physical activity plays a critical role in promoting physical and mental health, positively influencing the prevention of non-communicable diseases (NCDs) and enhancing brain function. Research indicates that regular physical exercise, such as aerobic or strength training, aids in the prevention and treatment of mental disorders such as depression, schizophrenia, and Alzheimer’s disease. The biological mechanisms associated with physical activity include improved cerebral blood flow, modulation of neurotransmitter systems, and increased levels of neurotrophic factors like BDNF. Exercise also affects the balance of neurotransmitters, such as serotonin, dopamine, and GABA, contributing to improved mood, cognitive abilities, and quality of life. Additionally, physical effort reduces inflammation and oxidative stress, supporting brain health and countering neurodegenerative processes. Regular moderate exercise is an effective method to prevent central fatigue and enhance the adaptability of the central nervous system. This paper explores the complex impact of physical activity on mental health and cognitive function, emphasizing its vital role in supporting the therapy of neurological and psychiatric disorders.

Introduction and Purpose: Obesity is an escalating global health challenge, affecting over 2 billion individuals worldwide, contributing to many challenges for healthcare providers such as cardiovascular disorders, cancers, and type 2 diabetes mellitus. There is a need for effective treatments targeting T2DM, and obesity. Glucagon-like peptide-1 (GLP-1) receptor agonists developed originally for T2DM treatment, have emerged as key agents for weight loss. This review examines current evidence regarding efficacy, safety, and mechanisms of action of GLP-1 RAs, particularly semaglutide and tirzepatide in obesity and weight loss treatment. Description of the State of Knowledge: GLP-1 receptor agonists modulate appetite, resulting in lower calory intake. Gastric emptying and insulin secretion are also affected by GLP-1 RAs. Clinical trials consistently demonstrate significant weight loss, positive action on cardiovascular risk and better glycemic control. All GLP-1 RAs have common side effects which are gastrointestinal disorders, and gallbladder-related issues, but their safety profiles are acceptable. Summary: Available evidence recommends GLP-1 receptor agonists in type 2 diabetes mellitus and obesity treatment. Tirzepatide and semaglutide are two pharmacological agents which show best results in terms of weight loss. Materials and Evidence: A literature review was conducted using the PubMed database for articles published from January 2016 to January 2024, supplemented by earlier foundational papers. After screening 121 abstracts, 51 full-text articles were assessed, and 30 were ultimately included.

Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance, beta-cell dysfunction, and chronic hyperglycemia. Despite the availability of conventional therapies, significant unmet needs persist in achieving optimal glycemic control and reducing long-term complications. GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors represent two novel classes of antidiabetic agents that have transformed the therapeutic landscape. This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. Challenges and future directions for these agents in personalized diabetes care are also discussed.

Introduction and purpose: Pregnancy is a remarkable and delicate period in a woman's life, marked by significant physiological adaptations to accommodate the growing fetus. These changes affect every organ system, including the skin. The aim of this review paper is to raise awareness and assist clinicians in recognizing, diagnosing, and effectively managing these distinct skin conditions associated with pregnancy. Material and methods: An extensive examination of articles published in scientific journals was carried out through online research platforms PubMed and Google Scholar. We searched articles by entering keywords in appropriate configuration: “pregnancy dermatoses”, “pemphigoid gestationis”, “ polymorphic eruption of pregnancy”, “intrahepatic cholestasis of pregnancy”, “pustular psoriasis of pregnancy”, “atopic eruption of pregnancy”. Description of the state of knowledge: This diverse set of pregnancy-related skin conditions includes pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, atopic eruption of pregnancy, and pustular psoriasis of pregnancy. Summary: Early diagnosis and treatment are crucial to mitigate maternal and fetal complications, and in some conditions, prevent fatalities. Improving clinicians' in-depth understanding of these disease processes can enhance patient safety and quality of life during and after pregnancy.

Background. Recent research has demonstrated intriguing relationships between martial arts practice, particularly Kyokushin Karate Katas (KKK), biophotonic emissions, and changes in water properties. This emerging field connects traditional mind-body practices with modern biophysical measurements. Purpose. To analyze and synthesize current evidence regarding the mechanisms of information transfer between practitioners of Kyokushin Karate and water, focusing on biophotonic emissions, neurophysiological changes, and subsequent effects on recipients of treated water. Methods. We reviewed primary research focusing on: (1) biophotonic emissions during martial arts practice, (2) water structure modifications through mental practices, and (3) neurophysiological effects of treated water. Key papers from 2010-2024 were analyzed, with particular attention to the pioneering work of Babelyuk et al. (2024, 2025) and related studies in biophoton research. Results. Evidence suggests that KKK practice induces measurable changes in practitioners' biophotonic emissions, particularly from brain regions and fingertips. These changes correlate with specific EEG patterns and entropy measures. Water exposed to practitioners during KKK shows altered properties, including modified light emission characteristics and structural changes. Recipients consuming treated water demonstrate neurophysiological changes, even under double-blind conditions. Conclusions. The reviewed research suggests a potentially viable mechanism for information transfer from practitioner to water through biophotonic emissions, with subsequent biological effects on recipients. These findings bridge traditional Eastern practices with Western biophysical measurements, opening new avenues for understanding mind-body interactions.

Introduction and purpose: Endometriosis is a gynecological disease that affects about 10% of women worldwide. Women suffering from endometriosis are susceptible to mental health disorders, such as depression and anxiety. It is essential to highlight the psychological struggles of women with endometriosis in order to integrate physical and psychological care and subsequently enhance the treatment outcomes. Materials and Methods: Medical databases such as Pubmed, Embase, Google Scholar were searched for scientific papers on endometriosis and its relationship with the symptoms of depression and anxiety. Research outlined the influence of endometriosis treatment, social stigmatization and non-medicinal approach. State of knowledge: The prevalence of depression and anxiety among women with endometriosis is significant. The symptoms of the disease influence daily struggles, relationship with partners and family, education and career responsibilities, subsequently lowering the quality of life. Women with endometriosis experience social stigmatization manifested not only from society members but also from healthcare professionals. The approach to the medical treatment by patients was discovered to be of consequence. Literature review emphasizes the benefits of psychological support and empathetic attitude of medical practitioners. Conclusions: Multidisciplinary team is essential in order to provide intervention strategies leading to greater therapeutic outcomes in endometriosis treatment. Endometriosis and mental disorders are inextricably connected. More research is needed to accent the importance of mental health in the treatment of physical conditions.

Caffeine is one of the most widely consumed and studied stimulants worldwide with a long history in athletics as a performance enhancer. Although listed as a stimulant in the World Anti-Doping Agency’s (WADA’s) 2024 Monitoring Program, its use is not prohibited. Individual responses to caffeine vary widely due to factors like genetics, age, and lifestyle habits, such as smoking and diet. This paper examines caffeine's multifaced role in human metabolism, with an emphasis on athletes' training (endurance and strength) and post-exercise recovery. Our comprehensive review of literature indicates that caffeine typically ingested one hour before exercise in doses around 3-6 mg/kg raises metabolic rate, increases free fatty acids mobilization, extends time to exhaustion in running and cycling, improves maximal voluntary contraction and enhances high-speed muscular activity with low-load movements. It also blocks pain perception. These findings highlight caffeine’s role in endurance and strength sports. However, due to inconsistencies, further research is needed to develop exercise-specific protocols considering dose, timing, and training status. Caffeine aids recovery by reducing delayed - onset muscle soreness, improving glycogen resynthesis, and reducing fatigue. However, late consumption may affect sleep, requiring careful timing and dosage adjustments. Moreover, potential side and positive effects of caffeine ingestion need to be considered.

Introduction: Obesity is a serious health problem that affects a very large percentage of the population, including middle-aged and senior people. Overweight and obesity are risk factors for many diseases, including cardiovascular diseases and diabetes. Many papers have been produced investigating the effects of different types of training and diet on body fat levels in overweight and obese populations. One of the best studied forms of exercise is aerobic training. In this article, we will discuss the effects of aerobic training or its combination with resistance training on weight loss and fat burning in an elderly population, including those suffering from sarcopenic obesity. Aim of the study: To demonstrate the effects of aerobic training and the combination of aerobic training and resistance training on weight loss, body fat reduction and other relevant health parameters in a middle-aged and older population. Methods: A review of the literature available in PubMed and Google Scholar databases conducted using key words such as obesity, older adults, overweight, aerobic, resistance training. The review of available publications mainly focused on studies with the strongest scientific evidence such as randomised controlled trials and meta-analyses. Conclusion: Physical exercise is a crucial part of the fight against obesity. The implementation of training supports weight reduction and, at the same time, has a positive impact on fitness and physical performance. Aerobic training has a positive effect on weight loss, but the best results are obtained when aerobic training is accompanied by resistance training, as it has a positive effect on muscle strength and muscle tissue quality and has a positive effect on bone mineral density (BMD). However, it should be noted that significant fat reduction requires the implementation of a calorie deficit.

This paper examines the impact of playing tennis on the visual system, providing an in-depth analysis of physiological, adaptive, and risk-related aspects associated with the sport. The dynamic nature of tennis necessitates intensive visual engagement to track a fast-moving ball, thereby enhancing dynamic vision, depth perception, and visuomotor coordination. On the other hand, the sport also poses risks such as eye strain and mechanical injuries, including corneal and retinal damage. The study underscores the importance of peripheral vision in the game and the need for the visual system to adapt to varying lighting conditions. The authors highlight the benefits of implementing vision exercises and protective measures, such as sunglasses and contact lenses. The significance of preventive measures, regular eye check-ups, and education for players, coaches, and parents is also emphasized. Although demanding, tennis offers opportunities to improve visual functions, contributing to athletic development and visual health.

Introduction and purpose: Chronic rhinosinusitis (CRS) is a frequently diagnosed condition in patients seeking medical care. It encompasses a range of disorders that can be classified based on underlying causes, clinical symptoms, or inflammatory types. Although the precise cause of CRS remains unclear, the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020) has recently offered updated insights, treatment strategies, and recommendations. State of knowledge: Recent research has increasingly focused on the role of the microbiota in inflammatory diseases. The optimal bacterial environment in the sinonasal mucosa, where inhaled bacteria, viruses, fungal spores, and particles initially interact, is still not fully understood. The dysbiosis theory, which emphasizes the importance of the microbiome and its relationship with the host, is the predominant model explaining CRS pathogenesis. Disruptions in this balance can lead to a variety of clinical manifestations in CRS patients. Conclusions: Given the impact of CRS treatment on the composition of sinus and nasopharyngeal microbiota, the dysbiosis theory highlights the importance of addressing this aspect in therapeutic strategies. Ongoing research is exploring the potential use of pre- and probiotics as novel treatment options. A more thorough understanding of the microbiological factors involved in CRS is crucial for developing personalized, targeted therapies for affected individuals.

Introduction and purpose Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant genetic disorder characterized by a significantly increased risk of developing various malignancies, including ovarian cancer. This study aims to analyse the risk of ovarian cancer development in patients with Lynch syndrome and to compare the diagnostic and therapeutic approaches for this neoplasm in the context of sporadic cases. Description This discussion explores the genetic mechanisms underlying mutations in mismatch repair (MMR) genes, such as MLH1, MSH2, MSH6, and PMS2, which are essential for maintaining genomic stability. The diagnostic criteria, including the Amsterdam Criteria and the Bethesda Guidelines, are reviewed. The paper highlights the diagnostic challenges posed by the nonspecific symptoms of ovarian cancer and emphasizes the importance of early detection and monitoring. A comprehensive review of treatment modalities is also provided, covering surgical cytoreduction, chemotherapy, and emerging therapies, such as immunotherapy and cancer vaccines. The importance of interdisciplinary care for patients is underscored, along with the need for preventive measures and health education to manage cancer risk. Summary Despite the challenges associated with diagnosis and treatment, the prognosis for patients with ovarian cancer linked to Lynch syndrome is generally more favourable than for those with sporadic cancers. This can be attributed to earlier diagnosis and the favourable histopathological characteristics of tumours associated with Lynch syndrome.

Introduction and objective: Varicose veins in the lower extremities are a clinical manifestation of chronic venous disease. The condition is highly prevalent, with incidence increasing with age. Varicose veins are often accompanied by pain, and neglecting treatment can lead to complications such as superficial vein inflammation, deep vein thrombosis, and, most critically, pulmonary embolism. The primary aim of this study was to analyze and compare the efficacy and safety of available contemporary invasive methods for treating varicose veins in the lower extremities. Additionally, this paper addresses the epidemiology, etiology, and clinical presentation of chronic venous insufficiency. Review methods: The literature review utilized databases covering sources from PubMed, Google Scholar, Web of Science and Scopus. Keywords included: ‘varicose veins of the lower limbs’; ‘spider veins’; ‘EVLT (endovenous laser treatment of the small saphenous vein and great saphenous vein)’; ‘sclerotherapy’; ‘diode laser’; ‘varicose vein surgeries of the lower limbs’. Brief description of the state of knowledge: Numerous methods for treating lower limb varicose veins are available. Among all treatment options, minimally invasive procedures using laser technology, steam, or radiofrequency waves are the most common. These procedures have been successfully performed for many years, with an estimated effectiveness of approximately 90% over a five-year observation period. Summary: Despite the high prevalence and complex pathophysiological mechanisms of varicose veins in the lower extremities, current treatment methods allow for a satisfactory therapeutic outcome in most patients.

Introduction: Long COVID is a complication of the coronavirus disease. As a relatively new medical condition, it presents challenges in establishing consistent principles for its classification, diagnosis, and treatment. Objective: The aim of this paper is to review the current knowledge regarding the new medical condition known as Long COVID in children. Materials and Methods: The review includes works published between 2020 and 2024, available in the PubMed database, identified using relevant keywords, as well as the WHO publication "World Health Organization. A clinical case definition for post COVID-19 condition in children and adolescents by expert consensus, 16 February 2023." Results: The literature review revealed that Long COVID is a relatively common issue, affecting up to 25.24% of children and adolescents. Identified risk factors include age over 10 years, severe primary infection, MIS-C, female gender, allergic diseases, obesity, living in polluted areas, comorbidities, poor physical and mental health, and prior respiratory infections. The spectrum of LC symptoms is broad and includes many nonspecific manifestations. The diversity of symptoms complicates diagnosis and necessitates a more holistic approach to patient care. Treatment of LC in children also poses a challenge. Most available studies focus on adults, with limited reports suggesting the efficacy of lactoferrin in managing gastrointestinal symptoms of LC in children. Physical activity is also suggested as an effective rehabilitation method for addressing reduced physical capacity and chronic fatigue. Conclusions: There is an urgent need for large-scale studies on the risk factors, causes, symptoms, and treatment of LC in children and adolescents. Developing cohesive guidelines would improve patients' quality of life, facilitate diagnosis, and streamline treatment processes.

The present paper aims to provide an overview of the use of biologically active components derived from mineral, synthetic, phyto-, and organic sources in the development of local hemostatic agents. The study highlights the historical and contemporary use of these agents in medical practice, and examines the scientific evidence supporting their efficacy. Hemostasis, the process of stopping bleeding, is a critical component of surgical and medical procedures. Local hemostatic agents are widely used to achieve hemostasis in a targeted and controlled manner, thereby minimizing the risk of complications associated with bleeding. The use of biologically active components derived from various sources, including minerals, synthetic materials, plants, and organic compounds, has a long history in the development of hemostatic agents. These components can act through various mechanisms, such as inducing platelet aggregation, activating the coagulation cascade, or promoting the formation of blood clots. Recent advances in biotechnology and nanotechnology have led to the development of novel hemostatic agents with improved properties, such as enhanced biocompatibility, targeted delivery, and controlled release. These agents have the potential to revolutionize hemostasis in surgical and medical procedures, and improve patient outcomes. Overall, the study highlights the importance of biologically active components derived from mineral, synthetic, phyto-, and organic sources in the development of local hemostatic agents. The review of historical and contemporary use of these agents underscores their continued relevance in medical practice, while recent advances in technology offer exciting new possibilities for future development. After a thorough review of domestic and foreign literature, the development team used adsorbing materials from biologically active components of mineral, synthetic, phyto-, and organic origin to create a hemostatic powder known as "PLANTOR." The active components of PLANTOR include aerosol, carrageenan of a special brand, and a specific mixture of medicinal vegetable oils, which have a special sorption effect. Due to the well-selected composition of the product, PLANTOR forms a blood clot in the wound through a biophysical process of liquid absorption. Notably, PLANTOR does not contain procoagulant minerals or nanoparticles that could remain in the human body, and therefore does not belong to means with a chemical or biochemical mechanism of action. Based on the above, it is possible to recommend the hemostatic agent-powder "PLANTOR" of the trade mark "PLANTOR tm" and "Dr. Sokolovskiy R" of the manufacturer "Medpro Nutraceuticals" (Latvia) by order of LLC "Plantor" (Ukraine, Dnipro), the author and owner of the developed technology of the hemostatic agent - powder "PLANTOR" (TU U 20.4-44827581-001:2022) as an auxiliary means of revitalization, local coagulation, treated wound surfaces during emergency medical care for external bleeding.

Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age, characterized by hormonal imbalances, insulin resistance, and a range of clinical manifestations, including infertility and metabolic disturbances. Effective management of PCOS remains a challenge due to its multifaceted nature, necessitating a comprehensive understanding of therapeutic options. Aim of the Study: This paper aims to explore the role of various treatment modalities for PCOS, with a particular emphasis on the use of metformin, an antidiabetic medication increasingly recognized for its benefits in managing insulin resistance and other associated conditions in PCOS patients. Conclusion: The findings highlight metformin's three primary mechanisms of action: enhancing insulin sensitivity, inhibiting hepatic gluconeogenesis, and influencing lipid metabolism. Metformin is effective in improving metabolic parameters and restoring ovulatory function in women with PCOS. While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS.

The following paper aims to discuss melanoma located in the eye. Melanoma is a malignant tumor arising from melanocytes, in which a mutation has occurred in the DNA and pathological cells have developed. In most cases, this tumor is located on the skin exposed to sunlight, but it is also rarely located in the structures of the eye, especially in the part called uvea. It consists of the anterior and posterior parts, and in each of them the process of carcinogenesis can occur. The disease can cause very non-specific symptoms, mainly pain, visual disturbances, floaters and photopsia, or exophthalmos, but almost half of the cases are asymptomatic. Treatment is complicated and depends on many factors, radiation therapy, laser therapy, local resection and enucleation are used. Most patients are diagnosed when the changes are already extensive, or metastases occur. In the case of liver metastases, the prognosis is unfavorable. For this reason, we want every doctor to pay attention to the eye symptoms reported by the patient in order to be able to recognize this disease as soon as possible and treat it effectively.

Introduction: Trigeminal neuralgia (TN) is a form of neuropathic pain that targets the fifth cranial nerve, leading to intense facial pain that can significantly impact one’s quality of life. This condition typically manifests as recurring episodes of sharp, unilateral pain along one or more branches of the trigeminal nerve.The exact mechanism of trigeminal neuralgia remains largely unknown. Most pain attacks are triggered by certain stimuli in the areas served by the trigeminal nerve. One possible treatment approach for trigeminal neuralgia is radiofrequency thermocoagulation. Aim: The aim of this article is to explore the underlying mechanisms of trigeminal neuralgia and assess the effectiveness of treating it through radiofrequency thermocoagulation of the Gasserian ganglion. Review methods: A comprehensive analysis of research papers available on PubMed and Google Scholar was undertaken using the searchterms encompassing the following keywords: trigeminal neuralgia / Gasserian ganglion radiofrequency thermal therapy/ radiofrequency thermal coagulation/ radiofrequency trigeminal rhizotomy/ trigeminal neuralgia mechanism. Conclusion: The exact mechanisms behind trigeminal neuralgia are still unclear, but several theories suggest that factors such as inflammation, ion channel dysfunction, neuroinflammatory conditions, or bioresonance issues may be involved. Radiofrequency Thermocoagulation (RFT) has proven to be an effective option for easing pain in individuals suffering from Trigeminal Neuralgia. Research indicates that RFT not only significantly reduces pain initially but also provides a prolonged period of relief post-procedure. The temperature achieved during radiofrequency treatments is a key factor in determining the effectiveness of RFT.

Ageing is a complex process occurring simultaneously on various levels - visual, physical, mental. Some among many factors responsible for maintenance of good physical and mental health are various nutrients, vitamins, antioxidants and medical drugs. Within this review, selected substances that show anti-ageing potential were examined. This paper reviews data on model organisms concerning the effects of widely used drugs and dietary supplements on the lifespan of model organisms.