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Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance, beta-cell dysfunction, and chronic hyperglycemia. Despite the availability of conventional therapies, significant unmet needs persist in achieving optimal glycemic control and reducing long-term complications. GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors represent two novel classes of antidiabetic agents that have transformed the therapeutic landscape. This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. Challenges and future directions for these agents in personalized diabetes care are also discussed.

Introduction and purpose: Pregnancy is a remarkable and delicate period in a woman's life, marked by significant physiological adaptations to accommodate the growing fetus. These changes affect every organ system, including the skin. The aim of this review paper is to raise awareness and assist clinicians in recognizing, diagnosing, and effectively managing these distinct skin conditions associated with pregnancy. Material and methods: An extensive examination of articles published in scientific journals was carried out through online research platforms PubMed and Google Scholar. We searched articles by entering keywords in appropriate configuration: “pregnancy dermatoses”, “pemphigoid gestationis”, “ polymorphic eruption of pregnancy”, “intrahepatic cholestasis of pregnancy”, “pustular psoriasis of pregnancy”, “atopic eruption of pregnancy”. Description of the state of knowledge: This diverse set of pregnancy-related skin conditions includes pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, atopic eruption of pregnancy, and pustular psoriasis of pregnancy. Summary: Early diagnosis and treatment are crucial to mitigate maternal and fetal complications, and in some conditions, prevent fatalities. Improving clinicians' in-depth understanding of these disease processes can enhance patient safety and quality of life during and after pregnancy.

Background. Recent research has demonstrated intriguing relationships between martial arts practice, particularly Kyokushin Karate Katas (KKK), biophotonic emissions, and changes in water properties. This emerging field connects traditional mind-body practices with modern biophysical measurements. Purpose. To analyze and synthesize current evidence regarding the mechanisms of information transfer between practitioners of Kyokushin Karate and water, focusing on biophotonic emissions, neurophysiological changes, and subsequent effects on recipients of treated water. Methods. We reviewed primary research focusing on: (1) biophotonic emissions during martial arts practice, (2) water structure modifications through mental practices, and (3) neurophysiological effects of treated water. Key papers from 2010-2024 were analyzed, with particular attention to the pioneering work of Babelyuk et al. (2024, 2025) and related studies in biophoton research. Results. Evidence suggests that KKK practice induces measurable changes in practitioners' biophotonic emissions, particularly from brain regions and fingertips. These changes correlate with specific EEG patterns and entropy measures. Water exposed to practitioners during KKK shows altered properties, including modified light emission characteristics and structural changes. Recipients consuming treated water demonstrate neurophysiological changes, even under double-blind conditions. Conclusions. The reviewed research suggests a potentially viable mechanism for information transfer from practitioner to water through biophotonic emissions, with subsequent biological effects on recipients. These findings bridge traditional Eastern practices with Western biophysical measurements, opening new avenues for understanding mind-body interactions.

Introduction and purpose: Endometriosis is a gynecological disease that affects about 10% of women worldwide. Women suffering from endometriosis are susceptible to mental health disorders, such as depression and anxiety. It is essential to highlight the psychological struggles of women with endometriosis in order to integrate physical and psychological care and subsequently enhance the treatment outcomes. Materials and Methods: Medical databases such as Pubmed, Embase, Google Scholar were searched for scientific papers on endometriosis and its relationship with the symptoms of depression and anxiety. Research outlined the influence of endometriosis treatment, social stigmatization and non-medicinal approach. State of knowledge: The prevalence of depression and anxiety among women with endometriosis is significant. The symptoms of the disease influence daily struggles, relationship with partners and family, education and career responsibilities, subsequently lowering the quality of life. Women with endometriosis experience social stigmatization manifested not only from society members but also from healthcare professionals. The approach to the medical treatment by patients was discovered to be of consequence. Literature review emphasizes the benefits of psychological support and empathetic attitude of medical practitioners. Conclusions: Multidisciplinary team is essential in order to provide intervention strategies leading to greater therapeutic outcomes in endometriosis treatment. Endometriosis and mental disorders are inextricably connected. More research is needed to accent the importance of mental health in the treatment of physical conditions.

Caffeine is one of the most widely consumed and studied stimulants worldwide with a long history in athletics as a performance enhancer. Although listed as a stimulant in the World Anti-Doping Agency’s (WADA’s) 2024 Monitoring Program, its use is not prohibited. Individual responses to caffeine vary widely due to factors like genetics, age, and lifestyle habits, such as smoking and diet. This paper examines caffeine's multifaced role in human metabolism, with an emphasis on athletes' training (endurance and strength) and post-exercise recovery. Our comprehensive review of literature indicates that caffeine typically ingested one hour before exercise in doses around 3-6 mg/kg raises metabolic rate, increases free fatty acids mobilization, extends time to exhaustion in running and cycling, improves maximal voluntary contraction and enhances high-speed muscular activity with low-load movements. It also blocks pain perception. These findings highlight caffeine’s role in endurance and strength sports. However, due to inconsistencies, further research is needed to develop exercise-specific protocols considering dose, timing, and training status. Caffeine aids recovery by reducing delayed - onset muscle soreness, improving glycogen resynthesis, and reducing fatigue. However, late consumption may affect sleep, requiring careful timing and dosage adjustments. Moreover, potential side and positive effects of caffeine ingestion need to be considered.

Introduction: Obesity is a serious health problem that affects a very large percentage of the population, including middle-aged and senior people. Overweight and obesity are risk factors for many diseases, including cardiovascular diseases and diabetes. Many papers have been produced investigating the effects of different types of training and diet on body fat levels in overweight and obese populations. One of the best studied forms of exercise is aerobic training. In this article, we will discuss the effects of aerobic training or its combination with resistance training on weight loss and fat burning in an elderly population, including those suffering from sarcopenic obesity. Aim of the study: To demonstrate the effects of aerobic training and the combination of aerobic training and resistance training on weight loss, body fat reduction and other relevant health parameters in a middle-aged and older population. Methods: A review of the literature available in PubMed and Google Scholar databases conducted using key words such as obesity, older adults, overweight, aerobic, resistance training. The review of available publications mainly focused on studies with the strongest scientific evidence such as randomised controlled trials and meta-analyses. Conclusion: Physical exercise is a crucial part of the fight against obesity. The implementation of training supports weight reduction and, at the same time, has a positive impact on fitness and physical performance. Aerobic training has a positive effect on weight loss, but the best results are obtained when aerobic training is accompanied by resistance training, as it has a positive effect on muscle strength and muscle tissue quality and has a positive effect on bone mineral density (BMD). However, it should be noted that significant fat reduction requires the implementation of a calorie deficit.

This paper examines the impact of playing tennis on the visual system, providing an in-depth analysis of physiological, adaptive, and risk-related aspects associated with the sport. The dynamic nature of tennis necessitates intensive visual engagement to track a fast-moving ball, thereby enhancing dynamic vision, depth perception, and visuomotor coordination. On the other hand, the sport also poses risks such as eye strain and mechanical injuries, including corneal and retinal damage. The study underscores the importance of peripheral vision in the game and the need for the visual system to adapt to varying lighting conditions. The authors highlight the benefits of implementing vision exercises and protective measures, such as sunglasses and contact lenses. The significance of preventive measures, regular eye check-ups, and education for players, coaches, and parents is also emphasized. Although demanding, tennis offers opportunities to improve visual functions, contributing to athletic development and visual health.

Introduction and purpose: Chronic rhinosinusitis (CRS) is a frequently diagnosed condition in patients seeking medical care. It encompasses a range of disorders that can be classified based on underlying causes, clinical symptoms, or inflammatory types. Although the precise cause of CRS remains unclear, the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020) has recently offered updated insights, treatment strategies, and recommendations. State of knowledge: Recent research has increasingly focused on the role of the microbiota in inflammatory diseases. The optimal bacterial environment in the sinonasal mucosa, where inhaled bacteria, viruses, fungal spores, and particles initially interact, is still not fully understood. The dysbiosis theory, which emphasizes the importance of the microbiome and its relationship with the host, is the predominant model explaining CRS pathogenesis. Disruptions in this balance can lead to a variety of clinical manifestations in CRS patients. Conclusions: Given the impact of CRS treatment on the composition of sinus and nasopharyngeal microbiota, the dysbiosis theory highlights the importance of addressing this aspect in therapeutic strategies. Ongoing research is exploring the potential use of pre- and probiotics as novel treatment options. A more thorough understanding of the microbiological factors involved in CRS is crucial for developing personalized, targeted therapies for affected individuals.

Introduction and purpose Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant genetic disorder characterized by a significantly increased risk of developing various malignancies, including ovarian cancer. This study aims to analyse the risk of ovarian cancer development in patients with Lynch syndrome and to compare the diagnostic and therapeutic approaches for this neoplasm in the context of sporadic cases. Description This discussion explores the genetic mechanisms underlying mutations in mismatch repair (MMR) genes, such as MLH1, MSH2, MSH6, and PMS2, which are essential for maintaining genomic stability. The diagnostic criteria, including the Amsterdam Criteria and the Bethesda Guidelines, are reviewed. The paper highlights the diagnostic challenges posed by the nonspecific symptoms of ovarian cancer and emphasizes the importance of early detection and monitoring. A comprehensive review of treatment modalities is also provided, covering surgical cytoreduction, chemotherapy, and emerging therapies, such as immunotherapy and cancer vaccines. The importance of interdisciplinary care for patients is underscored, along with the need for preventive measures and health education to manage cancer risk. Summary Despite the challenges associated with diagnosis and treatment, the prognosis for patients with ovarian cancer linked to Lynch syndrome is generally more favourable than for those with sporadic cancers. This can be attributed to earlier diagnosis and the favourable histopathological characteristics of tumours associated with Lynch syndrome.

Introduction and objective: Varicose veins in the lower extremities are a clinical manifestation of chronic venous disease. The condition is highly prevalent, with incidence increasing with age. Varicose veins are often accompanied by pain, and neglecting treatment can lead to complications such as superficial vein inflammation, deep vein thrombosis, and, most critically, pulmonary embolism. The primary aim of this study was to analyze and compare the efficacy and safety of available contemporary invasive methods for treating varicose veins in the lower extremities. Additionally, this paper addresses the epidemiology, etiology, and clinical presentation of chronic venous insufficiency. Review methods: The literature review utilized databases covering sources from PubMed, Google Scholar, Web of Science and Scopus. Keywords included: ‘varicose veins of the lower limbs’; ‘spider veins’; ‘EVLT (endovenous laser treatment of the small saphenous vein and great saphenous vein)’; ‘sclerotherapy’; ‘diode laser’; ‘varicose vein surgeries of the lower limbs’. Brief description of the state of knowledge: Numerous methods for treating lower limb varicose veins are available. Among all treatment options, minimally invasive procedures using laser technology, steam, or radiofrequency waves are the most common. These procedures have been successfully performed for many years, with an estimated effectiveness of approximately 90% over a five-year observation period. Summary: Despite the high prevalence and complex pathophysiological mechanisms of varicose veins in the lower extremities, current treatment methods allow for a satisfactory therapeutic outcome in most patients.

Introduction: Long COVID is a complication of the coronavirus disease. As a relatively new medical condition, it presents challenges in establishing consistent principles for its classification, diagnosis, and treatment. Objective: The aim of this paper is to review the current knowledge regarding the new medical condition known as Long COVID in children. Materials and Methods: The review includes works published between 2020 and 2024, available in the PubMed database, identified using relevant keywords, as well as the WHO publication "World Health Organization. A clinical case definition for post COVID-19 condition in children and adolescents by expert consensus, 16 February 2023." Results: The literature review revealed that Long COVID is a relatively common issue, affecting up to 25.24% of children and adolescents. Identified risk factors include age over 10 years, severe primary infection, MIS-C, female gender, allergic diseases, obesity, living in polluted areas, comorbidities, poor physical and mental health, and prior respiratory infections. The spectrum of LC symptoms is broad and includes many nonspecific manifestations. The diversity of symptoms complicates diagnosis and necessitates a more holistic approach to patient care. Treatment of LC in children also poses a challenge. Most available studies focus on adults, with limited reports suggesting the efficacy of lactoferrin in managing gastrointestinal symptoms of LC in children. Physical activity is also suggested as an effective rehabilitation method for addressing reduced physical capacity and chronic fatigue. Conclusions: There is an urgent need for large-scale studies on the risk factors, causes, symptoms, and treatment of LC in children and adolescents. Developing cohesive guidelines would improve patients' quality of life, facilitate diagnosis, and streamline treatment processes.

The present paper aims to provide an overview of the use of biologically active components derived from mineral, synthetic, phyto-, and organic sources in the development of local hemostatic agents. The study highlights the historical and contemporary use of these agents in medical practice, and examines the scientific evidence supporting their efficacy. Hemostasis, the process of stopping bleeding, is a critical component of surgical and medical procedures. Local hemostatic agents are widely used to achieve hemostasis in a targeted and controlled manner, thereby minimizing the risk of complications associated with bleeding. The use of biologically active components derived from various sources, including minerals, synthetic materials, plants, and organic compounds, has a long history in the development of hemostatic agents. These components can act through various mechanisms, such as inducing platelet aggregation, activating the coagulation cascade, or promoting the formation of blood clots. Recent advances in biotechnology and nanotechnology have led to the development of novel hemostatic agents with improved properties, such as enhanced biocompatibility, targeted delivery, and controlled release. These agents have the potential to revolutionize hemostasis in surgical and medical procedures, and improve patient outcomes. Overall, the study highlights the importance of biologically active components derived from mineral, synthetic, phyto-, and organic sources in the development of local hemostatic agents. The review of historical and contemporary use of these agents underscores their continued relevance in medical practice, while recent advances in technology offer exciting new possibilities for future development. After a thorough review of domestic and foreign literature, the development team used adsorbing materials from biologically active components of mineral, synthetic, phyto-, and organic origin to create a hemostatic powder known as "PLANTOR." The active components of PLANTOR include aerosol, carrageenan of a special brand, and a specific mixture of medicinal vegetable oils, which have a special sorption effect. Due to the well-selected composition of the product, PLANTOR forms a blood clot in the wound through a biophysical process of liquid absorption. Notably, PLANTOR does not contain procoagulant minerals or nanoparticles that could remain in the human body, and therefore does not belong to means with a chemical or biochemical mechanism of action. Based on the above, it is possible to recommend the hemostatic agent-powder "PLANTOR" of the trade mark "PLANTOR tm" and "Dr. Sokolovskiy R" of the manufacturer "Medpro Nutraceuticals" (Latvia) by order of LLC "Plantor" (Ukraine, Dnipro), the author and owner of the developed technology of the hemostatic agent - powder "PLANTOR" (TU U 20.4-44827581-001:2022) as an auxiliary means of revitalization, local coagulation, treated wound surfaces during emergency medical care for external bleeding.

Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age, characterized by hormonal imbalances, insulin resistance, and a range of clinical manifestations, including infertility and metabolic disturbances. Effective management of PCOS remains a challenge due to its multifaceted nature, necessitating a comprehensive understanding of therapeutic options. Aim of the Study: This paper aims to explore the role of various treatment modalities for PCOS, with a particular emphasis on the use of metformin, an antidiabetic medication increasingly recognized for its benefits in managing insulin resistance and other associated conditions in PCOS patients. Conclusion: The findings highlight metformin's three primary mechanisms of action: enhancing insulin sensitivity, inhibiting hepatic gluconeogenesis, and influencing lipid metabolism. Metformin is effective in improving metabolic parameters and restoring ovulatory function in women with PCOS. While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS.

The following paper aims to discuss melanoma located in the eye. Melanoma is a malignant tumor arising from melanocytes, in which a mutation has occurred in the DNA and pathological cells have developed. In most cases, this tumor is located on the skin exposed to sunlight, but it is also rarely located in the structures of the eye, especially in the part called uvea. It consists of the anterior and posterior parts, and in each of them the process of carcinogenesis can occur. The disease can cause very non-specific symptoms, mainly pain, visual disturbances, floaters and photopsia, or exophthalmos, but almost half of the cases are asymptomatic. Treatment is complicated and depends on many factors, radiation therapy, laser therapy, local resection and enucleation are used. Most patients are diagnosed when the changes are already extensive, or metastases occur. In the case of liver metastases, the prognosis is unfavorable. For this reason, we want every doctor to pay attention to the eye symptoms reported by the patient in order to be able to recognize this disease as soon as possible and treat it effectively.

Introduction: Trigeminal neuralgia (TN) is a form of neuropathic pain that targets the fifth cranial nerve, leading to intense facial pain that can significantly impact one’s quality of life. This condition typically manifests as recurring episodes of sharp, unilateral pain along one or more branches of the trigeminal nerve.The exact mechanism of trigeminal neuralgia remains largely unknown. Most pain attacks are triggered by certain stimuli in the areas served by the trigeminal nerve. One possible treatment approach for trigeminal neuralgia is radiofrequency thermocoagulation. Aim: The aim of this article is to explore the underlying mechanisms of trigeminal neuralgia and assess the effectiveness of treating it through radiofrequency thermocoagulation of the Gasserian ganglion. Review methods: A comprehensive analysis of research papers available on PubMed and Google Scholar was undertaken using the searchterms encompassing the following keywords: trigeminal neuralgia / Gasserian ganglion radiofrequency thermal therapy/ radiofrequency thermal coagulation/ radiofrequency trigeminal rhizotomy/ trigeminal neuralgia mechanism. Conclusion: The exact mechanisms behind trigeminal neuralgia are still unclear, but several theories suggest that factors such as inflammation, ion channel dysfunction, neuroinflammatory conditions, or bioresonance issues may be involved. Radiofrequency Thermocoagulation (RFT) has proven to be an effective option for easing pain in individuals suffering from Trigeminal Neuralgia. Research indicates that RFT not only significantly reduces pain initially but also provides a prolonged period of relief post-procedure. The temperature achieved during radiofrequency treatments is a key factor in determining the effectiveness of RFT.

Ageing is a complex process occurring simultaneously on various levels - visual, physical, mental. Some among many factors responsible for maintenance of good physical and mental health are various nutrients, vitamins, antioxidants and medical drugs. Within this review, selected substances that show anti-ageing potential were examined. This paper reviews data on model organisms concerning the effects of widely used drugs and dietary supplements on the lifespan of model organisms.

Introduction and objective: A plant-based diet is being adopted by an increasing number of people worldwide. Its health benefits have been described in numerous scientific studies. Unfortunately, an improperly balanced diet that excludes animal-derived products can, through various mechanisms, lead to deficiencies and disruptions in the functioning of many systems in the body. This review paper aims to present and summarize the findings and current literature on the impact of a plant-based diet on the menstrual cycle and female fertility. Brief description of the state of knowledge: There is insufficient research on how minerals and vitamins influence the biochemical processes of the menstrual cycle and related symptoms. While nutrient deficiencies in plant-based diets are widely discussed, most studies focus on general health rather than the reproductive system, which is crucial for hormonal balance and fertility. This highlights the need for more research to improve our understanding of the female reproductive and endocrine systems and ensure better care for women. Methods: A literature review was conducted using PubMed and Google Scholar with search terms like "impact of plant-based diet", "menstrual cycle disorders", "causes of female infertility", "deficiencies in vegans and vegetarians" and related variations. Articles published within the last five years were prioritized. Conclusions: A properly followed plant-based diet, supported by supplementation, has a positive effect on the female reproductive system, without causing menstrual cycle disorders or infertility. Unfortunately, the more exclusions present in the diet, the more likely it is to cause deficiencies in minerals and vitamins. Inadequate levels of these nutrients can lead to abnormalities in the female reproductive system, both in laboratory tests and in symptoms experienced by women.

The EVALI (E-cigarette or Vaping product use-Associated Lung Injury) epidemic of 2019 was a major public health challenge, attracting the attention of both the scientific community and the public. In a short period of time, thousands of cases of acute lung injuries and deaths were reported among e-cigarette users, previously unrelated to the risk, shedding new light on the safety of these devices and exposing gaps in the regulations regarding their use. This paper aims to review the literature on the EVALI epidemic, with particular emphasis on epidemiology, identification of the etiological agent, clinical presentation and treatment. Based on the collected data, the authors also analysed the possibilities of preventing similar events in the future, emphasizing regulations, health education of patients and increasing physicians' awareness of EVALI.

Introduction and Objective: Conjunctival melanoma (CM) is rare, particularly in children. It’s characterized by high aggressiveness and a tendency to metastasize. Due to the limited number of published case reports and studies in the pediatric population, it’s difficult to standardize diagnostic and therapeutic procedures. The aim of this paper is to collect and systematize the available information on cases of conjunctival melanoma in children. Materials and Methods: Two databases were used for the review: PubMed and Scopus. Additionally, references were manually searched. After removing duplicates, 283 articles were obtained, of which 20 were included in the review. The analysis included articles in English that contained detailed information on the course of CM in children. Abbreviated Description of the State of Knowledge: Conjunctival melanoma accounts for 2-5% of all eye tumors. Clinically, it presents as a pigmented lesion with heterogeneous shape and structure. Its development may be associated with UV radiation and genetic mutations. In diagnostic process, an ophthalmological examination is crucial, along with the search for potential metastases and recurrences. Treatment primarily involves surgical removal, with the addition of cryotherapy, chemotherapy, and radiotherapy if necessary. Summary: Despite rare occurrence of CM, due to its high aggressiveness, every conjunctival lesion should be thoroughly examined with oncological vigilance. The amount of data on this subject is limited, so further research is needed to help develop prognosis and management strategies. A greater number of studies in the future may also contribute to the development of new therapeutic options, thereby improving outcomes.

Introduction and purpose: Gradual progression of cognitive and physical disability negatively affects personal, social and economic well-being of patients with multiple sclerosis. This particular group of people has a high risk of developing depressive disorders. This study reviews the prevalence, current diagnostic tools and evidence-based methods of treating depression in patients suffering from MS. Material and Methods: This paper reviews various types of research documents with a special focus on sources from the past 10 years. Works from the 1980s and 1990s were also cited to outline the progress made in exploring the given topic. Its main aim is to indicate that MS poses a risk of developing depression and to emphasize that this disorder may be mistakenly attributed to the primary disease. It highlights the need for raising awareness about the topic to ensure interdisciplinary care. Results: The study proved the connection between the prevalence of depression in MS. Characteristic somatic depressive symptoms such as chronic fatigue, sleep disturbances, can conclude either from MS or depression. Because of that prevalence of depression in MS patients is artificially altered. Conclusion: The prevalence of depression is significantly greater in patients with multiple sclerosis compared to the general population. Many somatic symptoms caused directly by neurodegenerative changes pose difficulties in differential diagnosis. Multidisciplinary treatment, including both psycho- and pharmacotherapy, remains the most effective therapeutic approach. Nevertheless, the development of new, accurate diagnostic methods is necessary in order to screen for depression in this group of patients.

Background: Human demodicosis is a parasitic disease caused by two species of mites, Demodex folliculorum and Demodex brevis. Cutaneous and ocular demodicosis most often occurs in a situation of impaired immune response, where the attacked organism is weakened, has reduced immunity or metabolic disorders. The treatment of demodicosis can last up to several months and requires a lot of patience and regularity from the patient. Objective: The aim of this paper is to review the therapeutic options used in the treatment of the ocular and cutaneous human demodicosis. Materials and methods: This review was based on available data collected in the PubMed and Google Scholar databases, using the keywords: ‘Demodex brevis’, ‘Demodex folliculorum’, ‘Demodex mite’, ‘human demodicosis treatment’. Conclusions: Treatment of demodicosis based on the use of a single medicament has the lowest efficiency and effectiveness. In contrast, a combination therapies, in which oral and local applied medication are taken together or several types of local medication are combined have the best effect.

The recent era of rapid advancements in information technology has enabled various medical disciplines to tackle longstanding problems in novel ways. Among these, virtual reality (VR) has emerged as a promising alternative or complement to conventional physical therapy (CPT) for managing chronic musculoskeletal, degenerative, neurological, and pulmonary conditions. Increased patient motivation during treatment, low drop-out rates, and instant feedback are among the primary reasons VR is gaining trust among physicians, patients, and caregivers worldwide. Evidence suggests that VR can significantly enhance motor performance, cognitive skills, pulmonary function, activities of daily living (ADLs), quality of life (QoL), and even reduce pain intensity in several chronic diseases. Notably, patients with stroke, Parkinson’s disease, multiple sclerosis (MS), and chronic obstructive pulmonary disease (COPD) are poised to be the primary beneficiaries of VR. Thus, it appears that VR-based techniques are set to leave a footprint on clinical practice globally. However, challenges to the clinical adoption of VR remain, including technical limitations, the lack of standardized guidelines, and minor safety concerns that must be addressed. This paper summarizes the background, current developments, and key considerations for future research in this rapidly evolving field.

Introduction and purpose of this work CPPD is an arthropathy related to calcium pyrophosphate crystals’ deposition in joints triggering an inflammatory response leading to local articular damage. CPPD mainly affects the large and weight-bearing joints.In this review paper, our aim is to outline the current knowledge on epidemiology, origins, clinical manifest, diagnostical tools, new guidelines of the (ACR) and (EULAR) and current treatment options for CPPD. Methods: We performed a systematic electronic search on PubMed, Medline and Google Scholar databases. The search results were limited to publications from 2002 to 2024, as well as key studies and reference books from earlier years. Brief description of the state of knowledge CPP crystals in joints can lead to an inflammatory response and lead to joint damage. CPPD is the third most common reason of arthritis. Its origin is rather idiopathic, but there has been research showing the linkage of this disease to genetical background and some metabolic disorders.The treatment is chosen based on the phenotype of the disease.conventional pharmacological treatment includes NSAIDs, colchicine and corticosteroids. New opportunities to CPPD treatment have appeared thanks to biological medications which inhibit the inflammatory process. Summary Early diagnosis of CPPD, distinguishing it from other forms of arthritis and identifying the possible co-occurring diseases such as gout, rheumatoid arthritis and osteoporosis can help the clinicians to apply the proper treatment . Most patients are seniors with several comorbidities, this is why it is important to choose the right treatment, which prevents exacerbation of the inflammatory process and ensures high quality of life for the patients.

Introduction Vitamin D is one of the most important vitamins in affecting the human body. It turns out that its influence is not limited to its health-promoting effect on the skeletal system, but may also play an important role in the immune system. In our study, we focused precisely on this aspect of vitamin D's action. Review method We used materials from PubMed for this purpose. We focused on articles and research papers published between 2019 and 2024. We reviewed the publications in terms of vitamin D supplementation and its effects on immunity, disease processes, patient recovery, COVID-19 patients, and some autoimmune diseases. Results Some studies show that vitamin D supplementation significantly improves immune function. It also improves prognosis and reduces mortality in COVID-19. The number of complications and severity of the course also decreases. Vitamin D supplementation also has a positive effect on the course of autoimmune diseases, allowing a reduction in the incidence and improving the outcome of some of them. Unfortunately, not all studies prove such beneficial effects of vitamin D. What is important, however, is that vitamin D may have a beneficial effect on the course of diseases, and the low cost of its use and high availability may prove to be the key to medical development. Conclusions Based on the accumulated studies, it can be concluded that vitamin D contributes to the improvement of immune system function. Some studies prove the beneficial effect of vitamin D supplementation on the course of some autoimmune diseases. The potential benefits of vitamin D supplementation, as well as its low cost, should be a key argument for further research and knowledge on this topic.

Introduction and purpose: The topic of apple cider vinegar supplementation and insulin resistance is becoming increasingly widespread, especially on the internet, which carries many potential risks. There is a need to understand both how apple cider vinegar reduces insulin resistance and improves metabolic parameters, as well as the potential risks of its use. Material and methods: Medical databases like PubMed, Google Scholar, and Embase were searched for scientific papers on the safety, benefits, mechanisms, and risks of apple cider vinegar in insulin resistance and related conditions. These were analyzed and summarized in a single review. State of knowledge: Apple cider vinegar supplementation contributes to a reduction in insulin resistance, which is reflected in parameters such as decreased postprandial insulin secretion, lower levels of triglycerides (TG) and total cholesterol (TC), reduced fasting glucose, lower HbA1c levels, and supports weight loss, potentially improving insulin sensitivity. In most cases, no adverse effects or serious side effects were observed with doses of 15-30 ml per day. However, potential risks include delayed gastric emptying, exacerbation of gastroesophageal reflux disease (GERD), gastrointestinal disturbances, tooth erosion, although one study suggests that such supplementation may be associated with acute pancreatitis. Conclusions: More research is needed on supplementation, particularly regarding its duration. Another risk is the search for health information online without critically evaluating the content. Weight loss through a proper diet and exercise appears to be key for improving insulin sensitivity, but supplementation may help achieve results in certain patient groups.

Introduction Over the past few decades, the level of interest in the use of complex molecular pathways in the course of various diseases has increased significantly. Despite the rapid development of medicine, the potential and role of FKBP5 as a biomarker has not yet been fully characterized, although current studies are promising. Material and methods of research: The literature included in the PubMed databases is searched through the words such as FKBP5 gene, stress-related disorders, biomarkers. Aim of the study The aim of this paper is to provide a comprehensive review of the current state of knowledge regarding the characteristics, current use in diagnosis or treatment of various diseases and to determine the possible function of the biomarker for the FKBP5 gene. Description of the state of knowledge FKBP5 participates in the regulation of the HPA axis and thus in the stress response. This translates into the course of many diseases, but the exact mechanism of action has not been unequivocally confirmed in previous studies on all conditions involving FKBP5. Conclusions In general, FKBP5 has a huge diagnostic and therapeutic potential in many disease entities. FKBP5 may act as a biomarker. However, further studies are needed to clarify the current observations and to search for further implications in the pathogenesis or diagnostic and therapeutic procedures in the course of various diseases.

Introduction and objective Giant cell arteritis (GCA) is the most common primary systemic vasculitis in Europe. It mainly affects individuals over the age of fifty, its incidence increases with age. The most common clinical manifestation is bilateral headache accompanied by systemic symptoms. The disease may be associated with serious complications, such as permanent vision loss, stroke or rupture of aortic aneurysm. The aim of this study is to discuss the current knowledge about giant cell arteritis and new possibilities of biological treatment. Review methods To prepare this review, PubMed and Google Scholar databases were used, searching the following terms: “giant cell arteritis,” “temporal arteritis,” “giant cell arteritis biological treatment,” “giant cell arteritis biological therapy,” “giant cell arteritis treatment,” “giant cell arteritis epidemiology.” The search results were limited to publications from 2007 to 2024, as well as key studies from earlier years, including original papers and randomized, double-blind, placebo-controlled studies. Brief description of the state of knowledge The pathogenesis of GCA remains unclear. Since inflammatory factors appear to play an important role, new therapeutic strategies are aimed in direction to interfere these pathways. Setting a diagnosis of GCA requires imaging studies or a temporal artery biopsy. The results of current treatment with high doses of glucocorticoids are unsatisfying, which has led to ongoing research into new therapeutic options. Summary Early diagnosis and initiation of treatment are crucial for preventing occurrence of complications. Although the current treatment regimen is effective, it leads to many side effects and does not prevent relapses. This highlights the need to better understand the pathomechanism of the disease to develop more precise therapeutic strategies, including biological treatment.

Background: The purpose of this paper is to determine the impact of body development and composition on the depression level, and to determine which of the morphological and body composition parameters have higher impact on the manifestation of depression in women aged 19 to 30 years.Methods: The study was conducted on the sample of 50 voluntarily selected test subjects. From 83 women presented at the fitness center “Fitnes Center Mall” in the city of Gjakova for the purposes of this study are voluntarily involved 50 women aged 19 to 30 years with an average age of 23.2 years. For the purpose of this paper were applied 11 body composition variables and one test for measuring depression levels.Results: The obtained results show that the multiple correlation coefficient between the predictor and the criterion system is quite high R = 0.962. This relation shows that the common variability between the two systems is 93% (R Square = 0.926). Predictive variables that has the influence in the manifestation of depression level are: Height of the body body (HEIG) t=2.784; pBody mass index (BMI) t=2.908; pConclusions: The research results show that Height of the body, Body weight, and Body mass index affect in the rate of depression level. Research shows that although mental and physical health are two separate concepts, yet they are still in a strong relationship, physical condition affects in mental state.

Introduction and purpose: the Terminology Guidelines of the American Hippotherapy Association defines Equine Assisted Activities or Therapies (EAA/T) as a collection of different forms of contact between man and horse. EAA/T have become increasingly common interventions in the last decade, demonstrating therapeutic benefits in various areas of mental health. The aim of this report is to identify the forms and programmes of EAA/T that are used and to summarise and assess the latest available evidences of their clinical effectiveness in the treatment of symptoms of mental ilness and disorders such as autism spectrum disorders, post-traumatic stress syndrome or schizophrenia. In order to achieve the above mentioned objectives, a literature review has been conducted to summarise existing evidence relating to the subject matter of the study in a descriptive manner. Description of the state of knowledge: 13 findings were found in autism spectrum disorders (1 review paper and 5 research papers), post-traumatic stress syndrome (1 review paper and 4 research papers), schizophrenia (1 review paper), and children whose parents were addicted (1 research paper). Summary: the results of the research indicate that Equine Assisted Activities and Therapies (EAA/T), including horse riding, may be beneficial for people with mental illnesses and disorders, such as autism spectrum disorders, post-traumatic stress syndrome, schizophrenia, and for people whose parents were addicted.

Introduction: Patients with maxillofacial and intraoral defects require orthognathic surgery to improve the appearance of the face and correct the occlusion. The number of orthognathic surgeries has been increasing in recent years. The motivation to undergo these surgeries is the possibility for patients to improve stomatognathic system functions i.e. chewing, swallowing and pronunciation, as well as aesthetic and psychosocial factors. Aim: The aim of the paper was to assess the occurrence of late postoperative complications and dysfunction of the stomatognathic system in patients after orthognathic surgeries such as Maxillary Lefort 1 Osteotomy and Bilateral Sagittal Split Osteotomy (BIMAX). Additionally, the paper emphasizes the necessity of quick activation of the stomatognathic system structures in patients after orthognathic surgeries in order to reduce the incidence of complications.Material and methods: The research was conducted with the help of the users of internet groups: "Progenia, mandibular prognathism, photos BEFORE and AFTER the operation :)" (in Polish: „Progenia, wysunięta szczęka, zdjęcia PRZED i PO operacji :)”) and "Suffering from progenia" („Progenicy”) as well as users of the Jawsurgeryforums.com online forum who have given their informed consent to participate in the survey. The analysis was carried out on a group of 92 people who underwent orthognathic surgery of Maxillary Lefort 1 Osteotomy and Bilateral Sagittal Split Osteotomy (BIMAX) type in the years 2004-2019. To assess the opinions of patients, a diagnostic questionnaire method was used, based on a proprietary electronic questionnaire, which consisted of three parts. The first part is metric, i.e.: age, gender and questions concerning the number of orthognathic surgeries performed, time of wearing intermaxillary traction wiring or splints, postoperative rehabilitation. The second part of the questionnaire consisted of 15 close-ended questions assessing the occurrence of symptoms of SS system disorders and functioning. The third part of the questionnaire consists of 20 questions concerning postoperative complications after 3 and 6 months from surgery and functioning of the dental system after surgery. The fourth part of the questionnaire consists of 5 close-ended questions concerning the evaluation of the overall impression after surgery and the most important effects of it. The test results were statistically analyzed using the correlation coefficient and Pearson's chi-squared test (p ≤ 0.05).Results: 92 people, of which 86 women (93.5%) and 6 men (6.5%), participated in the study. The most common ailments before the surgery—affecting more than half of the patients—were chewing impairment, speech defect, breathing problems and headaches. 3 months after the operation, facial neurosensory disturbances and facial swelling were the most frequent of the ailments reported by the patients (more than 70% of the respondents), limited jaw mobility, joint pains and chewing impairment were also frequent (more than 40%). 6 months after the surgery, the most frequent persisting ailments were facial neurosensory disturbances (> 60%), facial swelling and acoustic problems (> 30%), as well as pains of masticatory and mandibular muscles, headaches and limited joint mobility (> 20%). More than half of the patients (n=48) were satisfied with the surgery, the second largest group were patients delighted with the result (n=25). 4 people were dissatisfied and 3 very dissatisfied. 12 patients had difficulties in determining their satisfaction with the results of the surgery. 19 people (20.7%) did not report disturbances of somatosensory system in any of the facial areas, and among the patients experiencing ailments, 40 people (43.5%) reported problems in two areas, 27 people (29.3%) in one, 5 people (5.4%) in four and 1 person (1.1%) in three areas. In the 3rd month after the surgery it was observed that people who did not use physiotherapeutic treatment were 11.5% more likely to suffer from bone inflammation [X2(1)=4.359; p=0.037]. Two statistical tendencies were observed, suggesting that people using physiotherapy slightly less often showed limitations in mandibular mobility [by 17.6%; X2(1)=3.599; p=0.065] and by 4.7% less often experienced bone inflammation [X2(1)=1.238; p=0.076]. Conclusions: The most common postoperative complication is somatosensory system disturbance of the lower facial muscles. Orthognathic surgery contributes to the reduction of stomatognathic system ailments. Persons using physiotherapy suffer less frequently from bone inflammation and enjoy greater mobility of the temporomandibular joint.

IntroductionThe nurse provides medical care for the patient, including nursing, administering medicines and performing injections. She assists the doctor in the process of diagnosis and treatment. The definition of this profession changes as a result of the development of science and increasing expectations of health care. The development of this profession is evidenced by developed models of nursing, which will focus on the practical application of the acquired knowledge.Aim The aim of this work was to present the tasks and competences of nursing and the role of this profession in improving the quality of patient care.Material and methodThe paper uses the method of literature analysis. The material used in the paper comes from publications published in a compact form and scientific articles.ResultsThe review of the collected scientific material showed that nurses have a significant impact on the quality of health care and the functioning of the entire facility. Healthcare institutions belong to organizations in which the quality of services translates into the patient's health and life. Care should therefore be a priority for the entire staff, especially for the nurses who first meet the patient and spend a lot of time with him. Patients expect medical knowledge from nurses first and foremost, but also safety, trust and proper communication.ConclusionsIn recent years, nursing has been constantly changing, which means that people in this profession have to take various actions for their development. Patient expectations are also changing. Their opinion and satisfaction is important for success. A satisfied patient will surely use the services of the facility again.

Communication management in sports organizations requires not only the use of formal tools, such as an official website, fan page or official TV channel. Effective communication should also be based on informal methods, in which the main role is played by interactions between the sports organization and its stakeholders. One such form is viral marketing, which involves sharing files with humorous, social or image content on social networks, messengers, blogs and e-mail. In the case of such forms, due to the wide range and speed of spreading opinions, especially negative ones, about the company, its services or products, it becomes necessary to control the emerging opinions. Management of information with a viral potential allows you to reach stakeholders in an informal way, influencing the building of a positive image, response in crisis situations or creating communities. The purpose of this paper is to analyze the degree of viral marketing use in sports clubs. The research was conducted in October 2021 on different social media. However, due to the extensive scope of the research, this paper focuses on the social network Facebook. The research is concerned with determining the use of viral marketing potential in information management and identifying the characteristics of this form of influencing stakeholders. Due to the limited volume of the article, the main subject of the study is the Polish clubs of the highest level of competition against the background of examples from abroad. The main hypothesis of this article assumes that Polish clubs do not fully use the viral potential and communication activities are based on official messages. Communication management is based on peer benchmarking and replication of what others are doing. It is also assumed that departments responsible for communication in sports clubs do not fully use foreign models.

Today’s economic reality requires entrepreneurs to introduce many changes, especially those of an organisational nature. The period following COVID-19 pandemic will require organizations to create new values, and a broader view of responsibility, to build mutual trust, and to adapt to the new reality. This paper introduces the principles of Corporate Social Responsibility (CSR), with a focus on ecology as one of the areas of CSR. It can be seen that the pandemic has accelerated environmental targets in many companies. This is due not only to the regulations aligned with the governmental environmental policy, but to an increasing extent also with changing social expectations. The aim of the article was to demonstrate the applicability of ecological, environment-friendly solutions as an example of CSR in the management of sports and leisure enterprises. CPOR studies show that most young people take responsibility for the state of their environment. The training of the test subjects also plays an important role here (CBOS, Environmental Awareness of Poland, 2020) It is assumed that the introduction of eco-friendly solutions in the operation of sports and leisure businesses is noticed and appreciated only by young participants in physical activity. The survey focuses on specific environmental solutions to create a socially responsible corporate image and how these companies operate in a changing environment. The results of the studies carried out for this paper are intended to help answer the question of the importance of emphasising environmental aspects and adapting to change by integrating eco-innovation into the CSR strategies of sports and leisure companies, whether these solutions are perceived by the purchasers of sports and leisure services, as they affect their image. and whether they lead to better relations with market participants.

Purpose: The aim of the paper is to present the economic situation of two publicly listed companies: GKS Katowice (Poland) and Olympique Lyonnais (France). Both enterprises have different ownership models: Olympique Lyonnnais is a privately owned club, and GKS Katowice belongs to a municipal government. However, both clubs operate in the realities of different market economic system (Poland and France) and also at a different level of economic development. It is common that football companies function under uncertainty and risk. This is heightened by additional characteristic factors for this type of activity such as uncertainty of outcome in sports competition. The adoption of professional sport activities also automatically runs to the risk, but this is not the only problem that the company has to face. In addition, both clubs had to deal with new challenges: COVID-19 pandemic and lockdowns. The paper presented the functioning of both football companies during the COVID-19 pandemic and lockdowns. Methodology: The first part of this research study discusses some particular points of the business strategy and risk management in the context of football companies’ management. The economic and financial situation of two football companies is presented, namely: Olympique Lyonnais and GKS Katowice. The focus is on sports, economic and financial criteria to assess the standing of football companies. This paper combines the conclusions from secondary data analysis, content analysis of web­sites as well as qualitative and quantitative analysis. The study also employs a comparative analysis. Research and practical limitations: Football companies are in the need to take several actions: a) continuously search for new sources of financing and diversification of activities, b) conclude long sponsorship agreements. Building a solid financial foundation and looking into the future can help football companies get through times of various crises and the COVID-19 pandemic.

Introduction and aims of the study: The aim of this study is to present recent reports on the treatment and therapy of schizophrenia and bipolar disorder (ChAD). The current treatment of patients affected by these diseases is difficult and unsatisfactory, therefore it is necessary to find new therapeutic options that will improve the effectiveness of treatment For the purpose of this study, scientific papers were reviewed using the Google Scholar search engine covering studies from 2016 to 2021. A dozen papers covering the scope of the publication were selected. Results: In the treatment of schizophrenia, the use of cannabinoids is of greatest interest due to the action of the preparations on the endocannabinoid system. In the treatment of ChaD, promising reports have been published on the therapy with aripiprazole and the need to improve its use in the treatment of both akathisia and agitation. Furthermore, from the fact that abnormalities of calcium signalling are considered a possible pathophysiological process in ChAD, it has been suggested that calcium channel L antagonists may be potential therapeutic agents in bipolar affective disorder. One study also demonstrated the potential use of vortioxetine in the treatment of patients with a depressive episode. Conclusions: The results of recent studies on the treatment of schizophrenia and ChAD cited in this paper offer the prospect of creating treatment regimens that are more effective and targeted in the aforementioned diseases. However, further randomised trials are needed to confirm the effective use of the cited drugs in the treatment of these diseases.

The physiotherapy process in children is specific and requires much more patience and understanding than in adults. Working with a child is not only related to the physiotherapy of a small patient, but also in a very good cooperation between the parent-physiotherapist. The paper presents selected issues of children's therapy in the light of research papers published in renowned scientific journals dealing with medical issues.

Athletic operates on the basis of a particular system of knowledge that has in its contentthe theoretical and methodological foundations of sport training (Rashiti N, Nika F, Bekolli L, Heta G.) 2017. Athletic is one of the types of sports, with complex and applicable character, consisting of large groups, which include different athletic types, with similar characteristics among them; our treatment is athletic decathlon.(Dibra F.)2006. The decathlon is a complexcombined event in athletic consisting of ten track and field events.Olympic men’s decathlons are divided into a two-day competition. The evaluation is done by points.Men’s decathlonconsists of:100m,Long jump,Shot put,High jump, 400m (Day 1); 110m hurdles,Discus throw,Pole vault,Javelin throw,1500m(Day 2).The main purpose of this paper was to verify that from the disciplines of the Decathlon:Long jump,Shot put,High jump, Discus throw,Pole vault,Javelin throw and1500m,as predictor (independent) variables will have an impact on the performance of specific motor tasks, respectively the execution of disciplines pertaining to short-distance running:100m, 110m hurdles and 400mas well as to determine the impact of these short-distance running to the final result of the decathlon knowing that these disciplines in athletics are largely genetically determined.(Misja B.) 2012The sample for the purposes of this paper will include 10 first contestants of decathlons World Championship: September 27 and October 6, 2019 in Doha, Qatar.In this research, after obtaining a statistically significant multiple correlation (R = 0.936) it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor variable (independent) in the dependent or criterion variable 400m.We can emphasize that the test (F-test) is always more valuable if the multiplex correlation is greater, in this case it is significant (Sig = 0.000), because the value of the F-test is 15,347.A statistically significant multiple correlation was obtained (R = 0.958); it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor (independent) variable in the dependent variable or criterion 110 m.In this research, after obtaining a statistically significant multiple correlation (R = 0.958), it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor variable (independent) in the dependent or criterion variable) 100 m.

Introduction and purpose of paper: The aim of this paper was to present diagnostic and therapeutic difficulties in management of sinonasal tumors, which are extremely rare. First symptoms are not specific, that is why patients usually present with advanced tumors at the moment of diagnosis. Optimal treatment depends upon extent or stage of disease. State of knowledge: Tumors of nose cavity and paranasal sinuses affecting less than 1 in 100 000 people per year. They are result of abnormal proliferation of variety of structures in the nose. Tumors in sinonasal region grow slowly and may invade local structures, for example the skull base, orbit, or brain. Symptoms of tumors of this region are not specific. This is reason why they are often misdiagnosed by the doctors. Proper detection and diagnostic examination require histopathology examination and imaging test such as computed tomography and magnetic resonance imaging. Due to type and stage of tumor, the treatment options are surgery, radiation therapy and chemotherapy, used separate or in combination. Summary: Nasal cavity and paranasal sinus tumors are rare, with a wide spectrum of histological differentiation. The accurate diagnosis of tumor plays a significant role influencing the therapeutic conduct and prognosis.

Breast cancer is the most common cancer occurring in the female population. Early diagnosis and appropriately implemented treatment results in high curability. The method of choice is surgery, depending on the extent of the changes, a radical method is used, consisting in complete removal of the mammary gland, or sparing. Additional, complementary methods of treatment are radiation, chemotherapy and hormone therapy. Surgery involves interference with tissue continuity and hence scarring. During the procedure, mechanical long pectoral nerve injury may also occur. The paper presents an example of a case study using kinesiotaping as a complementary method of rehabilitation of women after mastectomy with long pectoral nerve damage. The paper analyzes available literature and own experience

This paper tackles the issue of image, with an emphasis on personal image (personal PR). Image was selected as the focal point of this article as, according to the author, it is an indispensable element of media life and functioning in the society. There are numerous definitions of image in both Polish and foreign literature. In his or her definition, each author attempts to incorporate the aspects most important to the world of business and its actors. This paper is centered on distinguishing between such concepts as image, reputation and identity, as well as portrays the evolution of image in time and growing social awareness of the notion, and presents the methodology of building image. This study aims to determine the image of Renata Małgorzata Mauer-Różańsk as it is presented in the national press. The articles referencing the former Olympian analyzed herein were sourced from three nationwide dailies: Fakt, Gazeta Wyborcza and Super Express. The entire material collected and analyses allow to conclude that Renata Małgorzata Mauer-Różańska has a moderately positive image. On the one hand, she is viewed as an authority figure and a walking icon and, on the other, as a person who is withdrawn, afraid to step out of her comfort zone and avoids social media, as well as industry events.

Breast cancer is a disease most often affecting women in the modern world and a huge challenge for modern medicine. "Breast cancer is not a sentence" - such statement is presented by one of the authors of the book position used in this paper. However, considering statistical data, every tenth woman asks herself whether this statement is true due to the highest percentage of cases of this disease among females. There may be many reasons for this situation, but one should also look at them in the lack of awareness of women about breast cancer prevention. Preventive actions are of considerable importance. They allow real recognition of the problem and implementation of activities aimed at reducing the risk of disease. Undoubtedly, some people are not aware of the seriousness of this situation, and the second part wonders what the reason for such a high percentage of cases is. The answer is simple - women do not perform self-examination of breasts, do not participate in preventive examinations and report to the doctor when the cancer process is already advanced. Aim of this paper The aim of this paper was to evaluate knowledge and activities for oncological prevention of women invited for mammography screening as part of the "Population program for early detection of breast cancer". Material and methods The study covered 105 randomly selected women in rural and urban areas of the Podkarpackie Voivodeship aged 50-69 covered by the "Population program for the early detection of breast cancer. The research was conducted in the period from 09/01/2017 to 10/31/2017. The author's questionnaire consisting of 32 questions was used for the research. The research was voluntary and anonymous.For the purpose of this work, the following tests were used for questions on nominal scales for verification of hypotheses: V Kramer (2x3 tables, 4x5 etc.), Phi (2x2 tables) - these are symmetric measures based on chi-square test informing about the strength of dependencies between variables in cross tables. For questions on ordinal scales, Tb - Kendall or Tc tests were used - the first for 2x2 tables, the second 2x3, 4x5 tables, etc. The statistical analysis was carried out using the SPSS program and all relationships are statistically significant when p

Introduction and and purpose of paper: The aim of this paper was to present modern methods of treatment for endometriosis. Endometriosis is a chronic inflammatory condition of women that is characterized by the implementation of endometrial tissue outside the uterus. It affects 7 to 15% of menstruating women, and 35 to 50% of women treated for infertility. State of knowledge: Diagnosis of endometriosis is made on the basis of well-collected gynecological history, clinical examinations and imaging techniques. The golden standard for diagnostics is laparoscopy with subsequent histological examination of the material collected during the procedure. Among the methods of treatment in women with endometriosis, pharmacological and surgical treatment is applied. The pharmacological agents most commonly used in endometriosis are: combined hormonal contraceptives, progestins and anti-progestins, GnRH agonists and antagonists, aromatase inhibitors, Danazol and non-steroidal anti-inflammatory drugs (NSAIDs). Pharmacological treatment is only symptomatic, not cytoreductive, therefore, to remove endometriosis lesions, surgery should be performed. There are two ways to perform surgery: laparotomy and laparoscopy. Surgical treatment of endometriosis may be associated with local excision of lesions and sometimes even removal of the entire organ. Treatment should be conducted in consultation with the patient and her wishes. Conservative treatment is most commonly used among women of reproductive age. Summary: The pharmaceutical or surgical treatment require an individual approach and deliberated informed consent of patient. Pharmacological treatment is only symptomatic, not cytoreductive, therefore, to remove endometriosis lesions, surgery should be performed.

Physiotherapy section - physicotherapy successfully applies frequent cryotherapy treatments in many different diseases. The paper presents a review of the literature on the basis of review papers as well as research papers from reputable scientific journals, which have been published over the last few years.

Kinesiology taping, called in Poland more and more often dynamic plastering is a method with a very wide application. More and more often this method is noticed among patients. Currently, many studies have been conducted, in which the effectiveness of therapy with the use of tapes for kinesiology taping has been proven. What is more, no harmful effects of this form of therapy have been found. In addition, there is more and more research showing the effectiveness of cathodiology taping as a form of supporting the effects of the main therapy. The paper was written on the basis of review articles and research papers presented in reputable Polish magazines dealing with physiotherapy.

Nowadays, there are more and more reports of child abuse. However, this is not due to an increase in violence against minors, but to an increase in public awareness. People have begun to report child abuse. Child Abuse Syndrome affects both physical and psychological violence. There are many risk factors. Correct diagnosis is difficult, especially for children who start walking, running and all kinds of injuries can be the result of their playing. Intelligence, accurate viewing of the child and physical examination has an important role. When discussing the child abuse syndrome, let’s not forget about Munchausen syndrome per procura. Then the child’s testimonies are invented, very often behind the story presented by the young patient there is a family member – mainlythe mother. Since September 2011, all health care workers are subject to the “Blue Card” procedure. [11,27] If child abuse has occurred in the family, or even if there is a suspicion of such abuse, an Interdisciplinary Team is established. The task of this team is to complete the Blue Card procedure and to ensure the safety of a victim of violence. A paramedic plays an important role in this procedure. In most cases it is the person who first comes into contact with a child who is a victim of abuse. The paramedic must ensure that the patient feels safe. Their task is to identify the problem, document the injuries occurring on the child’s body at the time of examination and fill in the appropriate documentation, which will be handed over to the Interdisciplinary Team. This paper presents materials explaining the epidemiology and clinical image of the child abuse syndrome. Social aspects and legal consequences of this issue are also discussed. The “Blue Card” procedure and the “Blue Bear” form are also presented. The paper explains the role of medical personnel in case of violence against children.

Introduction and purpose: Psoriasis is a chronic, inflammatory skin condition that affects millions of individuals worldwide. Recent research has suggested a potential link between psoriasis and vitamin D deficiency. This review paper aims to examine the existing literature on the relationship between psoriasis and vitamin D, exploring the potential role of vitamin D in the pathogenesis and management of this debilitating skin disorder. Materials and method: An extensive examination of articles published in scientific journals was carried out through online research platforms PubMed and Google Scholar. We searched articles by entering keywords in appropriate configuration: “psoriasis”, “vitamin D”, “obesity”. Description of the state of knowledge: Emerging research has identified a connection between vitamin D and the development of various skin conditions, including psoriasis. Consistent findings have shown a significant association between low vitamin D levels and the presence of psoriasis. Furthermore, due to vitamin D's influence on the proliferation and maturation of keratinocytes, it has become an important local treatment option for managing psoriasis. Summary: Although there is no clear consensus on whether sufficient dietary vitamin D or oral vitamin D supplements effectively treat psoriasis, the available evidence is still inconclusive. However, healthcare providers like nutritionists should consider recommending general vitamin D supplementation for populations at high risk of vitamin D deficiency, such as those with psoriasis or obesity.

Diverticulosis is a common condition of the bowel, particularly affecting the sigmoid colon with age-dependent increase in prevalence. While often asymptomatic and discovered incidentally during colonoscopies or imaging, some patients experience symptoms like left lower abdominal pain, bloating, and irregular bowel habits. When symptoms arise, it is termed diverticular disease (DD). Approximately 10% of diverticulosis cases progress to diverticulitis, which involves inflammation and can lead to complications like abscesses, perforation, or obstruction. In the U.S., acute diverticulitis accounts for 200,000 hospitalizations annually, costing about $2.2 billion in healthcare. The purpose of this paper is to review the current understanding of modifiable risk factors associated with the development and progression of diverticular disease

introduction and purpose: The numerous advantages of sport are widely known. Millions of children worldwide are encouraged to start training and significant part of them decide to start professional training. However, there are also certain health risk connected with intensive physical activity. One of them is female athletes triad – a syndrome consisting of three components: low energy availability (LEA), dysregulation of menstrual cycle and impaired bone mineral density (BMD). description of the state of knowledge: The intensive physical activity, especially in adolescent women may have deleterious influence on their health and, in consequence, on further sports career. Female athletes triad often co-occurs with eating disorders, especially in sports where slim shape is desirable. Inadequate energy availability results in menstrual cycle dysfunction, meanwhile insufficient level of female sex hormones (estrogens) is detrimental for bones health leading to frequent injuries and stress fractures. In result the vicious cycle of female athletes triad is closed and general condition of athlete deteriorates. summary: This paper aims to briefly review current state of knowledge on female athletes triad. It is vital to raise awareness of female athlete triad symptoms among medical professionals as well as sportswomen and members of coaching team to facilitate early diagnosis and proper treatment to avoid further complications.

Migraine, a complex neurological disorder, affects a significant portion of the population and presents both medical and societal challenges. The aim of this paper is to provide a detailed review and analysis of available therapeutic methods for patients suffering from migraines, considering both pharmacological and non-pharmacological therapies. The approaches presented include acute treatment with triptans and nonsteroidal anti-inflammatory drugs (NSAIDs), as well as preventive therapies, such as beta-blockers and antiepileptic drugs. The section on non-pharmacological therapies focuses on cognitive-behavioral therapy (CBT), biofeedback, and lifestyle recommendations, including diet and sleep hygiene. A review of the literature indicates that integrating pharmacological and non-pharmacological approaches can significantly improve treatment effectiveness and the quality of life for patients with migraines.

Introduction: Neuroendocrine tumors (NETs) are a diverse group of tumors that arise from neuroendocrine cells and can synthesize and secrete neuropeptides or hormones. Although NETs usually originate from the gastrointestinal tract or bronchopulmonary tree, they can affect various organs, including the eye. The majority of ocular association with neuroendocrine tumors results from metastasis that affects the orbit, however, primary ocular tumors have been reported. Purpose of the study: The article reviews the presentation of ocular manifestations in neuroendocrine tumors including pheochromocytoma, ocular paraganglioma, gastrointestinal and bronchial NETs, Merkel cell carcinoma and neuroendocrine metastasis. Materials and methods: In order to summarize the current knowledge on the topic, a literature review of English language papers with a focus on the most current literature was performed. The review was conducted with the PubMed database with 43 works used, accessed before September 2024. Conclusions: Instances of neuroendocrine tumors leading to ocular manifestations have become increasingly prevalent. These nonspecific symptoms can make it challenging to diagnose ocular NETs. Ocular manifestations are not typically the primary symptom, but patients with tumors located in the eye may experience symptoms such as eye pain, blepharitis or exophthalmos. Ocular motility and vision may also be affected. It is crucial to study the association between those symptoms and NETs, in order to develop a more comprehensive understanding of the matter.