1. Mineralocorticoid receptor signalling in primary aldosteronism.
- Author
-
Jun Yang, Young, Morag J., Cole, Timothy J., and Fuller, Peter J.
- Subjects
- *
MINERALOCORTICOID receptors , *HYPERALDOSTERONISM , *KIDNEY exchange , *CELLULAR signal transduction , *KIDNEY diseases - Abstract
Primary aldosteronism, or Conn syndrome, is the most common endocrine cause of hypertension. It is associated with a higher risk of cardiovascular, metabolic and renal diseases, as well as a lower quality of life than for hypertension due to other causes. The multi-systemic effects of primary aldosteronism can be attri buted to aldosteronemediated activation of the mineralocorticoid receptor in a range of tissues. In this review, we explore the signalling pathways of the mineralocorticoid receptor, with a shift from the traditional focus on the regulation of renal sodium-potassium exchange to a broader understanding of its role in the modulation of tissue i nflammation, fibrosis and remodelling. The appreciation of primary aldosteronism as a multi-system disease with tissue-specific pathophysiology may lead to more vigilant testin g and earlier institution of targeted interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF