1. PHYSIOLOGICAL ACTIONS OF HUMAN FOLLICLE-STIMULATING HORMONE AND ITS β-SUBUNIT IN REPTILES
- Author
-
Antonella Bona Gallo, Ratna C. Shownkeen, Paul Licht, and Anne Stockell Hartree
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Stimulation ,Endocrinology ,In vivo ,Internal medicine ,biology.animal ,Testis ,medicine ,Animals ,Potency ,Dose-Response Relationship, Drug ,biology ,Lizard ,Lizards ,Snakes ,Biological activity ,Androgen ,In vitro ,Androgens ,Follicle Stimulating Hormone ,Protein Binding ,Hormone - Abstract
SUMMARY The actions of human follicle-stimulating hormone (hFSH) and its β-subunit were examined in several assays in reptiles, including effects on lizard testicular activity (growth and androgen production) in vivo, and stimulation of androgen production by snake testes and competition for binding of 125I-labelled hFSH in lizards and snakes in vitro. Binding was also examined with mammalian tissues. The hFSH was highly steroidogenic in the snake and lizard; otherwise results were similar to those observed in mammals. In all cases, the potency of the β-subunit was only a few per cent of the intact hormone. The potency of hFSH in vivo compared with NIH-FSH ovine standards was several 100 times greater than in vitro. Results for stimulation of androgen production in vivo closely paralleled those for binding assays in both reptiles and mammals. In contrast to previous results for ovine FSH β-subunit, human FSH β-subunit has little if any FSH biological activity in reptiles.
- Published
- 1977
- Full Text
- View/download PDF