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Bioproducts, such as energy and fertilizers, are strongly interrelated with the biodegradable waste treatment processes, within a holistic management strategy. Although different forms of biological treatment technologies are available, anaerobic digestion represents a process of major importance in the overall management strategy of biodegradable waste. This paper presents a methodology to support decision making for efficient management of biodegradable waste. The decision support framework provides the background towards the selection and design of a biodegradable waste installation with emphasis on the recovery of energy and organic fertilizer. The discrete steps are analytically defined and illustrated to assist managers and policy makers to organize their decision making in the whole spectrum of procedures required to promote sustainable biodegradable waste management programs. The methodological approach developed can be generically applied by public authorities, producers and stakeholders following essential basic steps regarding safe and environmentally friendly production of high-quality final product. Moreover, a demonstration is performed for a real-case study for the Region of Serres, Greece. The proposed installation is expected to manage 3,285 t of biodegradable waste and generate approximately 160,000 m3/a of biogas, 400 MWh el /a and 450 MWh thermal /a. The final bioproduct exceeds 3 kt of digestate that will be valorized in arable land close to the installation. Crucial interactions and managerial insights are also highlighted. The decision support framework aims to assist the research community, the private sector and decision makers to produce affordable and sustainable compost/digestate recovered from waste, also supporting the transition to a low carbon future and sustainable -circular- development. • Methodology to support decision for efficient management of biodegradable waste. • Emphasis on the recovery of energy and organic fertilizer via anaerobic digestion. • Demonstration for a real-life agricultural intensive area in Greece. • 3285 t of waste generate 160,000 m3/a of biogas and 3121 t of digestate. • The proposed installation is depreciated within a 7-to-8-year period. [ABSTRACT FROM AUTHOR]