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Your search keyword '"Patrizia Nadia Hanieh"' showing total 2 results
Start Over Author "Patrizia Nadia Hanieh" Journal journal of enzyme inhibition and medicinal chemistry
2 results on '"Patrizia Nadia Hanieh"'

1. Neem oil nanoemulsions: characterisation and antioxidant activity

Author

Federica Rinaldi, Patrizia Nadia Hanieh, Catia Longhi, Simone Carradori, Daniela Secci, Gokhan Zengin, Maria Grazia Ammendolia, Elena Mattia, Elena Del Favero, Carlotta Marianecci, and Maria Carafa

Subjects
Neem oil, nanoemulsions, physicochemical characterisation, antioxidant activity, cell interaction studies, Therapeutics. Pharmacology, RM1-950
Abstract

The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Physicochemical characterisation was carried out evaluating size, ζ-potential, microviscosity, polarity and turbidity of the external shell and morphology, along with stability in simulated cerebrospinal fluid (CSF), activity of Neem oil alone and in NEs, HEp-2 cell interaction and cytotoxicity studies. This study confirms the formation of NEs by Tween 20 and Neem oil at different weight ratios with small and homogenous dimensions. The antioxidant activity of Neem oil alone and in NEs was comparable, whereas its cytotoxicity was strongly reduced when loaded in NEs after interaction with HEp-2 cells.

Published
2017
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2. Neem oil nanoemulsions: characterisation and antioxidant activity

Author

Maria Grazia Ammendolia, Catia Longhi, Gokhan Zengin, Elena Mattia, Carlotta Marianecci, Federica Rinaldi, Patrizia Nadia Hanieh, Simone Carradori, Elena Del Favero, Daniela Secci, Maria Carafa, Selçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, and Zengin, Gökhan

Subjects
nanoemulsions, Antioxidant, medicine.medical_treatment, antioxidant activity, 02 engineering and technology, 010402 general chemistry, neem oil, physicochemical characterisation, cell interaction studies, 01 natural sciences, Antioxidants, Glycerides, Microviscosity, Structure-Activity Relationship, Pulmonary surfactant, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, Nonionic surfactant, Particle Size, Cytotoxicity, Droplet size, Cell Proliferation, Pharmacology, Active ingredient, Neem oil, Chromatography, Dose-Response Relationship, Drug, Chemistry, Terpenes, lcsh:RM1-950, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, lcsh:Therapeutics. Pharmacology, Nanoparticles, Emulsions, 0210 nano-technology, Research Paper
Abstract

PubMed: 28965424, The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Physicochemical characterisation was carried out evaluating size, ?-potential, microviscosity, polarity and turbidity of the external shell and morphology, along with stability in simulated cerebrospinal fluid (CSF), activity of Neem oil alone and in NEs, HEp-2 cell interaction and cytotoxicity studies. This study confirms the formation of NEs by Tween 20 and Neem oil at different weight ratios with small and homogenous dimensions. The antioxidant activity of Neem oil alone and in NEs was comparable, whereas its cytotoxicity was strongly reduced when loaded in NEs after interaction with HEp-2 cells. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group., Università degli Studi di Milano, EDF thanks BIOMETRA Dept., University of Milan, for financial support (Piano sostegno ricerca – Linea B 2016).

Published
2017

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