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Start Over Author "Nakamura, Yasuyuki" Journal journal of epidemiology
17 results on '"Nakamura, Yasuyuki"'

1. BMI and cardiometabolic traits in Japanese: a Mendelian randomization study

Author

Nagayoshi, Mako, primary, Hishida, Asahi, additional, Shimizu, Tomonori, additional, Kato, Yasufumi, additional, Kubo, Yoko, additional, Okada, Rieko, additional, Tamura, Takashi, additional, Otonari, Jun, additional, Ikezaki, Hiroaki, additional, Hara, Megumi, additional, Nishida, Yuichiro, additional, Oze, Isao, additional, Koyanagi, Yuriko N., additional, Nakamura, Yohko, additional, Kusakabe, Miho, additional, Ibusuki, Rie, additional, Shibuya, Keiichi, additional, Suzuki, Sadao, additional, Nishiyama, Takeshi, additional, Koyama, Teruhide, additional, Ozaki, Etsuko, additional, Kuriki, Kiyonori, additional, Takashima, Naoyuki, additional, Nakamura, Yasuyuki, additional, Katsuura-Kamano, Sakurako, additional, Arisawa, Kokichi, additional, Nakatochi, Masahiro, additional, Momozawa, Yukihide, additional, Takeuchi, Kenji, additional, and Wakai, Kenji, additional

Published
2023
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2. Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study

Author

Fujii, Ryosuke, primary, Hishida, Asahi, additional, Nishiyama, Takeshi, additional, Nakatochi, Masahiro, additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Nishida, Yuichiro, additional, Shimanoe, Chisato, additional, Nakamura, Yasuyuki, additional, Turin, Tanvir Chowdhury, additional, Suzuki, Sadao, additional, Watanabe, Miki, additional, Ibusuki, Rie, additional, Takezaki, Toshiro, additional, Mikami, Haruo, additional, Nakamura, Yohko, additional, Ikezaki, Hiroaki, additional, Murata, Masayuki, additional, Kuriki, Kiyonori, additional, Kuriyama, Nagato, additional, Matsui, Daisuke, additional, Arisawa, Kokichi, additional, Katsuura-Kamano, Sakurako, additional, Tsukamoto, Mineko, additional, Tamura, Takashi, additional, Kubo, Yoko, additional, Kondo, Takaaki, additional, Momozawa, Yukihide, additional, Kubo, Michiaki, additional, Takeuchi, Kenji, additional, and Wakai, Kenji, additional

Published
2022
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3. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Sumi, Masaki, Hisamatsu, Takashi, Fujiyoshi , Akira, Kadota, Aya, Miyagawa, Naoko, Kondo, Keiko, Kadowaki, Sayaka, Suzuki , Sentaro, Torii, Sayuki, Zaid Maryam, Sato, Atsushi, Arima, Hisatomi, Terada, Tomohiro, Miura, Katsuyuki, Ueshima , Hirotsugu, Horie Minoru, Nakano Yasutaka, Yamamoto Takashi, Hayashi Hideki, Ogawa Emiko, Maegawa Hiroshi, Miyazawa Itsuko, Murata Kiyoshi, Mitsunami Kenichi, Nozaki Kazuhiko, Tooyama Ikuo, Shiino Akihiko, Tsuru Teruhiko, Ogita Hisakazu, Shimizu Akio, Miyamatsu Naomi, Kita Toru, Kimura Takeshi, Nishio Yoshihiko, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Edmundowicz Daniel, Ohkubo Takayoshi, Hozawa Atsushi, Murakami Yoshitaka, Okuda Nagako, Arima Hisatomi, Kita Yoshikuni, Hisamatsu Takashi, Higashiyama Aya, Nagasawa Shinya, Azuma Koichiro, Yanagita Masahiko, Abbott Robert D., Kadota Aya, Ohno Seiko, Fujiyoshi Akira, Takashima Naoyuki, Kadowaki Takashi, Kadowaki Sayaka, Miyagawa Naoko, Kondo Keiko, Torii Sayuki, Saito Yoshino, Suzuki Sentaro, Ito Takahiro, Satoh Atsushi, and Yamazoe Masahiro

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Epidemiology, alcohol consumption, Population, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, visceral adipose tissue, Adverse effect, education, Nutrition, Aged, lcsh:R5-920, education.field_of_study, Anthropometry, business.industry, anthropometric obesity indice, Confounding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, fat deposition, Obesity, Subcutaneous Fat, Abdominal, Epidemiologic Studies, Cross-Sectional Studies, Population Surveillance, Original Article, lcsh:Medicine (General), Tomography, X-Ray Computed, business, Body mass index
Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend

Published
2019

4. Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study

Author

Hara, Megumi, primary, Nishida, Yuichiro, additional, Tanaka, Keitaro, additional, Shimanoe, Chisato, additional, Koga, Kayoko, additional, Furukawa, Takuma, additional, Higaki, Yasuki, additional, Shinchi, Koichi, additional, Ikezaki, Hiroaki, additional, Murata, Masayuki, additional, Takeuchi, Kenji, additional, Tamura, Takashi, additional, Hishida, Asahi, additional, Tsukamoto, Mineko, additional, Kadomatsu, Yuka, additional, Matsuo, Keitaro, additional, Oze, Isao, additional, Mikami, Haruo, additional, Kusakabe, Miho, additional, Takezaki, Toshiro, additional, Ibusuki, Rie, additional, Suzuki, Sadao, additional, Nakagawa-Senda, Hiroko, additional, Matsui, Daisuke, additional, Koyama, Teruhide, additional, Kuriki, Kiyonori, additional, Takashima, Naoyuki, additional, Nakamura, Yasuyuki, additional, Arisawa, Kokichi, additional, Katsuura-Kamano, Sakurako, additional, and Wakai, Kenji, additional

Published
2021
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5. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010

Author

Shibata, Yosuke, primary, Ojima, Toshiyuki, additional, Nakamura, Mieko, additional, Kuwabara, Kazuyo, additional, Miyagawa, Naoko, additional, Saito, Yoshino, additional, Nakamura, Yasuyuki, additional, Kiyohara, Yutaka, additional, Nakagawa, Hideaki, additional, Fujiyoshi, Akira, additional, Kadota, Aya, additional, Ohkubo, Takayoshi, additional, Okamura, Tomonori, additional, Ueshima, Hirotsugu, additional, Okayama, Akira, additional, and Miura, Katsuyuki, additional

Published
2019
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6. Relationship Between Socioeconomic Status and the Prevalence of Underweight, Overweight or Obesity in a General Japanese Population: NIPPON DATA2010

Author

Nakamura, Tomiyo, primary, Nakamura, Yasuyuki, additional, Saitoh, Shigeyuki, additional, Okamura, Tomonori, additional, Yanagita, Masahiko, additional, Yoshita, Katsushi, additional, Kita, Yoshikuni, additional, Murakami, Yoshitaka, additional, Yokomichi, Hiroshi, additional, Nishi, Nobuo, additional, Okuda, Nagako, additional, Kadota, Aya, additional, Ohkubo, Takayoshi, additional, Ueshima, Hirotsugu, additional, Okayama, Akira, additional, and Miura, Katsuyuki, additional

Published
2018
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7. Macronutrient Intake and Socioeconomic Status: NIPPON DATA2010

Author

Sakurai, Masaru, primary, Nakagawa, Hideaki, additional, Kadota, Aya, additional, Yoshita, Katsushi, additional, Nakamura, Yasuyuki, additional, Okuda, Nagako, additional, Nishi, Nobuo, additional, Miyamoto, Yoshihiro, additional, Arima, Hisatomi, additional, Ohkubo, Takayoshi, additional, Okamura, Tomonori, additional, Ueshima, Hirotsugu, additional, Okayama, Akira, additional, and Miura, Katsuyuki, additional

Published
2018
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8. Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

Author

Wakai, Kenji, primary, Hamajima, Nobuyuki, additional, Okada, Rieko, additional, Naito, Mariko, additional, Morita, Emi, additional, Hishida, Asahi, additional, Kawai, Sayo, additional, Nishio, Kazuko, additional, Yin, Guang, additional, Asai, Yatami, additional, Matsuo, Keitaro, additional, Hosono, Satoyo, additional, Ito, Hidemi, additional, Watanabe, Miki, additional, Kawase, Takakazu, additional, Suzuki, Takeshi, additional, Tajima, Kazuo, additional, Tanaka, Keitaro, additional, Higaki, Yasuki, additional, Hara, Megumi, additional, Imaizumi, Takeshi, additional, Taguchi, Naoto, additional, Nakamura, Kazuyo, additional, Nanri, Hinako, additional, Sakamoto, Tatsuhiko, additional, Horita, Mikako, additional, Shinchi, Koichi, additional, Kita, Yoshikuni, additional, Turin, Tanvir Chowdhury, additional, Rumana, Nahid, additional, Matsui, Kenji, additional, Miura, Katsuyuki, additional, Ueshima, Hirotsugu, additional, Takashima, Naoyuki, additional, Nakamura, Yasuyuki, additional, Suzuki, Sadao, additional, Ando, Ryosuke, additional, Hosono, Akihiro, additional, Imaeda, Nahomi, additional, Shibata, Kiyoshi, additional, Goto, Chiho, additional, Hattori, Nami, additional, Fukatsu, Mitsuru, additional, Yamada, Tamaki, additional, Tokudome, Shinkan, additional, Takezaki, Toshiro, additional, Niimura, Hideshi, additional, Hirasada, Kazuyo, additional, Nakamura, Akihiko, additional, Tatebo, Masaya, additional, Ogawa, Shin, additional, Tsunematsu, Noriko, additional, Chiba, Shirabe, additional, Mikami, Haruo, additional, Kono, Suminori, additional, Ohnaka, Keizo, additional, Takayanagi, Ryoichi, additional, Watanabe, Yoshiyuki, additional, Ozaki, Etsuko, additional, Shigeta, Masako, additional, Kuriyama, Nagato, additional, Yoshikawa, Aya, additional, Matsui, Daisuke, additional, Watanabe, Isao, additional, Inoue, Kaoru, additional, Ozasa, Kotaro, additional, Mitani, Satoko, additional, Arisawa, Kokichi, additional, Uemura, Hirokazu, additional, Hiyoshi, Mineyoshi, additional, Takami, Hidenobu, additional, Yamaguchi, Miwa, additional, Nakamoto, Mariko, additional, Takeda, Hideo, additional, Kubo, Michiaki, additional, and Tanaka, Hideo, additional

Published
2011
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13. Integration of Data from NIPPON DATA80/90 and National Nutrition Survey in Japan: For Cohort Studies of Representative Japanese on Nutrition

Author

Okuda, Nagako, primary, Miura, Katsuyuki, additional, Yoshita, Katsushi, additional, Matsumura, Yasuhiro, additional, Okayama, Akira, additional, Nakamura, Yasuyuki, additional, Okamura, Tomonori, additional, Saitoh, Shigeyuki, additional, Sakata, Kiyomi, additional, Ojima, Toshiyuki, additional, Turin, Tanvir Chowdhury, additional, and Ueshima, Hirotsugu, additional

Published
2010
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14. J Epidemiol 2010;20(Suppl 3):S506–S514 Integration of Data from NIPPON DATA80/90 and National Nutrition Survey in Japan: For Cohort Studies of Representative Japanese on Nutrition

Author

Okuda, Nagako, primary, Miura, Katsuyuki, additional, Yoshita, Katsushi, additional, Matsumura, Yasuhiro, additional, Okayama, Akira, additional, Nakamura, Yasuyuki, additional, Okamura, Tomonori, additional, Saitoh, Shigeyuki, additional, Sakata, Kiyomi, additional, Ojima, Toshiyuki, additional, Turin, Tanvir Chowdhury, additional, and Ueshima, Hirotsugu, additional

Published
2010
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15. GWAS of Folate Metabolism With Gene-environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study.

Author

Tsukamoto M, Hishida A, Tamura T, Nagayoshi M, Okada R, Kubo Y, Kato Y, Hamajima N, Nishida Y, Shimanoe C, Ibusuki R, Shibuya K, Takashima N, Nakamura Y, Kusakabe M, Nakamura Y, Koyanagi YN, Oze I, Nishiyama T, Suzuki S, Watanabe I, Matsui D, Otonari J, Ikezaki H, Katsuura-Kamano S, Arisawa K, Kuriki K, Nakatochi M, Momozawa Y, Takeuchi K, Wakai K, and Matsuo K

Subjects
Humans, Japan, Male, Female, Middle Aged, Adult, Aged, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Vitamin B 12 blood, Cohort Studies, Polymorphism, Single Nucleotide, East Asian People, Folic Acid blood, Genome-Wide Association Study, Gene-Environment Interaction, Homocysteine blood, Life Style
Abstract

Background: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites, as well as to detect related gene-environment interactions in Japanese., Methods: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B 12 (VB 12 ) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene-environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed., Results: For Hcy, MTHFR locus on chr 1, NOX4 on chr 11, CHMP1A on chr 16, and DPEP1 on chr 16 reached genome-wide significance (P < 5 × 10 -8 ). MTHFR also associated with FA, and FUT2 on chr 19 associated with VB 12 . We investigated gene-environment interactions in both studies and found significant interactions between MTHFR C677T and ever drinking, current drinking, and physical activity >33% on Hcy (β = 0.039, 0.038 and -0.054, P = 0.018, 0.021 and <0.001, respectively) and the interaction of MTHFR C677T with ever drinking on FA (β = 0.033, P = 0.048)., Conclusion: The present GWAS revealed the folate metabolism-associated genetic loci and gene-environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized cardiovascular disease prevention.

Published
2024
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16. BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study.

Author

Nagayoshi M, Hishida A, Shimizu T, Kato Y, Kubo Y, Okada R, Tamura T, Otonari J, Ikezaki H, Hara M, Nishida Y, Oze I, Koyanagi YN, Nakamura Y, Kusakabe M, Ibusuki R, Shibuya K, Suzuki S, Nishiyama T, Koyama T, Ozaki E, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Nakatochi M, Momozawa Y, Takeuchi K, and Wakai K

Subjects
Humans, Body Mass Index, Japan epidemiology, Cohort Studies, Genome-Wide Association Study, Mendelian Randomization Analysis, Obesity epidemiology, Obesity genetics, Polymorphism, Single Nucleotide, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 genetics, Hypertension
Abstract

Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated., Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses., Results: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with increased risks of higher blood pressure, triglycerides, and uric acid, as well as lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent using different methods, including the directions., Conclusion: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.

Published
2024
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17. Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study.

Author

Hara M, Nishida Y, Tanaka K, Shimanoe C, Koga K, Furukawa T, Higaki Y, Shinchi K, Ikezaki H, Murata M, Takeuchi K, Tamura T, Hishida A, Tsukamoto M, Kadomatsu Y, Matsuo K, Oze I, Mikami H, Kusakabe M, Takezaki T, Ibusuki R, Suzuki S, Nakagawa-Senda H, Matsui D, Koyama T, Kuriki K, Takashima N, Nakamura Y, Arisawa K, Katsuura-Kamano S, and Wakai K

Subjects
Humans, Male, Cohort Studies, Cross-Sectional Studies, Japan epidemiology, Female, Adult, Middle Aged, Aged, Glomerular Filtration Rate physiology, Risk Factors, Exercise physiology, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic prevention & control, Sedentary Behavior
Abstract

Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function., Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m 2 . Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied., Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68-0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52-2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD., Conclusion: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.

Published
2023
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