1. Plasma activin A concentrations during late gestation in Thoroughbred mares with abnormal pregnancies
- Author
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Munkhtuul Tsogtgerel, Harutaka Murase, Hidekazu Moriyama, Fumio Sato, and Yasuo Nambo
- Subjects
Activin A ,Equine ,Late-term fetal loss ,Maternal plasma ,Premature delivery - Abstract
application/pdf, Late-term fetal loss in horses is a major problem in the horse-breeding industry globally. Abnormal pregnancies should be diagnosed as early as possible to prevent abortions and other gestational problems. According to our previous longitudinal study in healthy pregnant mares, the plasma activin A concentration increases as pregnancy progresses. The aim of the present study was to compare plasma activin A concentrations in healthy pregnant Thoroughbred mares (n=40) with those in pregnant mares that suffered fetal loss or showed abnormal symptoms (n=30) during late gestation. This field study found that plasma activin A concentrations were higher in the abnormal group (pregnancy loss, red bag delivery, premature udder development, and vaginal discharge) than the normal group (P < 0.001; cutoff value: ≥ 138.2 pg/mL; sensitivity, 74.4%; specificity, 77.5%). More specifically, plasma activin A concentrations in the “symptom” and “abnormal delivery” subgroups were higher than those in gestational-age-matched normal groups (P < 0.001). Nevertheless, the plasma activin A concentration in the “normal delivery” subgroup was not different from that in the “abnormal delivery” subgroup in samples collected within 10 days before delivery. In conclusion, this study is the first to demonstrate a significantly earlier increase in plasma activin A concentration in abnormal pregnancies of Thoroughbred mares during late gestation. © 2022 Elsevier Inc.
- Published
- 2023