1. Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice.
- Author
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Yang EJ, Lee JS, Song BB, Yun CY, Kim DH, and Kim IS
- Subjects
- Animals, Anti-Inflammatory Agents pharmacology, Asthma immunology, Asthma metabolism, Bronchoalveolar Lavage Fluid, Cell Line, Eosinophilia drug therapy, Eosinophils metabolism, Female, Goblet Cells drug effects, Humans, Immunoglobulin E metabolism, Inflammation metabolism, Leukocytosis drug therapy, Lung immunology, Lung metabolism, Mice, Mice, Inbred BALB C, Mucus metabolism, Ovalbumin, Plant Extracts pharmacology, Plant Extracts therapeutic use, Pyroglyphidae, Reactive Oxygen Species metabolism, Anti-Inflammatory Agents therapeutic use, Asthma drug therapy, Cytokines metabolism, Inflammation drug therapy, Lagerstroemia, Lung drug effects, Phytotherapy
- Abstract
Aim of the Study: In the present study, we investigated whether the Lagerstroemia indica Linn (LI) extract has an anti-inflammatory effect on lung inflammation in ovalbumin-induced asthmatic mice., Materials and Methods: The LI extract was obtained from dried and powdered whole plants of LI using 80% ethanol. ELISA was performed to evaluate cytokine concentration. BALB/c mice were used as a mouse model of asthma after asthmatic induction by ovalbumin sensitization and inhalation. We examined the effects of the LI extract on leukocyte infiltration and mucus secretion using cell count and histological stain., Results: The amount of cytokines, such as interleukin (IL)-2, IL-4, IL-5, IL-13, and TNF-α, was increased in Jurkat cells using the extract from house dust mites. Increased cytokine concentrations were inhibited by the LI extract. The LI extract suppressed the increased expression of IL-6 after treatment with mite extract of EoL-1 cells and THP-1 cells. In an in vivo experiment using asthmatic mice, the LI extract significantly inhibited leukocytosis and eosinophilia in bronchoalveolar lavage (BAL) fluid and lung tissue samples. The LI extract inhibited the increase in mucus secretion by goblet cells, blocked the production of reactive oxygen species in BAL fluid cells, and blocked the protein expression of IL-5 in BAL fluid. The concentration of ovalbumin-specific IgE in BAL fluid was weakly inhibited by the LI extract., Conclusions: These results suggest that the LI extract may be used as a valuable agent for treating allergic diseases such as asthma due to its anti-inflammatory property., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2011
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