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1. SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model.

Author

Cao, Kerun, Zhong, Jialong, Wang, Shanshan, Shi, Yafei, Bai, Shasha, Zhao, Jinlan, Yang, Lei, Liang, Qi, Deng, Di, and Zhang, Rong

Subjects
*CHINESE medicine, *BIOLOGICAL models, *HERBAL medicine, *NEURONS, *ANTIDEPRESSANTS, *MICE, *GENE expression, *BRAIN stem, *ANIMAL experimentation, *PSYCHOLOGICAL stress, *SEROTONIN, *MENTAL depression, *GABA, *CELL receptors, *PHARMACODYNAMICS, *ADOLESCENCE
Abstract

[Display omitted] • SiNiSan exerts therapeutic effects on adolescent depression caused by stress in early life and adolescence. • SiNiSan downregulates N-methyl-D-aspartic acid (NMDA) receptor expression and regulates serotonergic/GABAergic neuron activity in theDRN region of adolescent depression models. • SiNiSan regulates neuronal activity by downregulating NMDA receptors in DRN of adolescent depression models. [ABSTRACT FROM AUTHOR]

Published
2024
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