10 results on '"Shun Wan"'
Search Results
2. Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species
- Author
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Xu Wu, Jiang Ma, Ping Li, Pang-Chui Shaw, Ge Lin, and Shun Wan Chan
- Subjects
0301 basic medicine ,Male ,Quality Control ,food.ingredient ,Chromatography, Gas ,Fritillaria ,Bronchi ,complex mixtures ,01 natural sciences ,Rats, Sprague-Dawley ,03 medical and health sciences ,food ,Alkaloids ,Drug Discovery ,Animals ,Family liliaceae ,Medicine, Chinese Traditional ,Pharmacology ,biology ,Traditional medicine ,010405 organic chemistry ,Plant Extracts ,Alkaloid ,Verticinone ,biology.organism_classification ,0104 chemical sciences ,Rats ,Trachea ,Antitussive Agents ,Disease Models, Animal ,030104 developmental biology ,Herb ,Relaxation effect ,Hupehenine ,Medicinal herbs ,Female ,Drugs, Chinese Herbal - Abstract
Ethnopharmacological relevance Fritillariae Bulbus (Beimu in Chinese) is derived from the bulbus of many Fritillaria species (family Liliaceae), which has been used as an antitussive herb in traditional Chinese medicine for more than 2000 years. Due to the complexity of plant origins and significant variations in chemical profiles, the characterization of the profile of the major bioactive constituents and its association with pharmacological activity are important for the quality control of Beimu herbs from different origins. Aim of the study This study aims to investigate the distribution of major bioactive isosteroidal alkaloids in Beimu herbs of different origins and its correlation with the tracheobronchial relaxant activity. Methods Quantification of 7 main bioactive 5α-cevanine isosteroidal alkaloids, including ebeiedine, ebeiedinone, hupehenine, isoverticine, verticine, verticinone and imperialine, in 23 Fritillaria species was performed using gas chromatography. The relaxant effect of different extracts of 4 commonly used Beimu herbs, namely Zhe-Beimu (F. thunbergii Miq.), Chuan-Beimu (F. cirrhosa D. Don), Hubei-Beimu (F. hupehensis Hsiao et K. C. Hsia) and Yi-Beimu (F. pallidiflora Schrenk), was evaluated using rat isolated tracheal and bronchial preparations pre-contracted with carbachol, the well established in vitro antitussive model. Results Amongst 23 Fritillaria species detected, significant variations of the types and quantities of 7 major isosteroidal alkaloids were determined, which served as an important indicator for the classification of different Beimu herbs with distinct geographic distributions. Based on the type and quantity of these alkaloids, different origins of Beimu could be clearly clustered into several subgroups by principal component analysis. Furthermore, both crude alkaloid and water extracts of all 4 Beimu herbs showed a dose-dependent tracheobronchial relaxation with different potencies. The total content of alkaloids (weight adjusted based on the activity of individual alkaloids) in Beimu extracts significantly correlated with their tracheobronchial relaxation effects (r2 > 0.9, p Conclusions The results demonstrated that the differences in chemical profile of major bioactive isosteroidal alkaloids and pharmacological activity of Beimu could be incorporated into a simple and unified method for quality control and potential prediction of activity of Beimu herbs from different origins.
- Published
- 2017
3. Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review
- Author
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Philip Chiu Tsun Tang, Yam-Fung Ng, Shun Wan Chan, Daniel K. W. Mok, Wing-Sum Lam, and Tung-Ting Sham
- Subjects
Pharmacology ,Traditional medicine ,business.industry ,Semen ,Astragalus Plant ,Intracellular reactive oxygen species ,Traditional Chinese medicine ,medicine.disease ,Astragalus complanatus ,Phytochemical ,Web of knowledge ,Diabetes mellitus ,Ethnopharmacology ,Seeds ,Drug Discovery ,medicine ,Animals ,Humans ,Plant Preparations ,Medicine, Chinese Traditional ,business ,Relevant information ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
Ethnopharmacological relevance Semen Astragali Complanati (SAC), the dried ripe seed of Flatstem Milkvetch (Astragalus complanatus Bunge) (Leguminosae), is commonly used in traditional Chinese medicine (TCM) for treating muscle, liver, kidney, blood, skin and reproductive system diseases. Materials and methods Relevant information about SAC was gathered via “Google Scholar”, “ISI Web of Knowledge”, “PubMed”, “ScienceDirect”, “Medline Plus”, “ACS”, “CNKI” and “Wiley Online Library” and from books in local libraries. Results The major contents of SAC include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements. Previous scientific studies have reported that SAC exhibits a number of therapeutic effects on chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers. It has been found that flavonoids are the main bioactive component in SAC. However most of the previous studies have shown the effects brought by the total flavonoid fraction extracted from SAC only; further studies are warranted for the biological effects produced by individual components. There are only a few studies on the toxicity of SAC and the overall results show that its toxicity is quite low or even non-existent. Conclusions SAC is a valuable TCM herb with multiple pharmacological effects for treating some chronic diseases. More studies on SAC will help us to have a better understanding of its pharmacological mechanisms so as to provide more scientific evidence to explain its traditional uses, identify its therapeutic potential on other diseases and understand its possible harmful effects. Based on previous studies, it is easy to identify that antioxidant effect of SAC might play an important role on its pharmacological effects. Studying the effects of SAC on handling intracellular reactive oxygen species may be a potential direction to help understanding the molecular mechanisms of SAC on preventing and/or treating chronic diseases.
- Published
- 2014
4. Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species
- Author
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Wu, Xu, primary, Chan, Shun-wan, additional, Ma, Jiang, additional, Li, Ping, additional, Shaw, Pang-chui, additional, and Lin, Ge, additional
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- 2018
- Full Text
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5. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways
- Author
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Lun Qing Zhang, Shun Wan Chan, Cheong Meng Chong, Fei Sa, Pui Man Hoi, Raymond Chuen-Chung Chang, Simon Ming-Yuen Lee, Zhong Yan Zhou, and Ying Wang
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SH-SY5Y ,Schisandra chinensis ,Dioxoles ,Pharmacology ,Biology ,medicine.disease_cause ,Nitric Oxide ,Neuroprotection ,Lignans ,Antiparkinson Agents ,Cyclooctanes ,Glycogen Synthase Kinase 3 ,Neuroblastoma ,Cell Line, Tumor ,Drug Discovery ,medicine ,Animals ,Humans ,Oxidopamine ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Zebrafish ,Schisandra ,Glycogen Synthase Kinase 3 beta ,Dopaminergic Neurons ,Neurodegeneration ,Dopaminergic ,biology.organism_classification ,medicine.disease ,Oxidative Stress ,Neuroprotective Agents ,Biochemistry ,Reactive Oxygen Species ,Proto-Oncogene Proteins c-akt ,Oxidative stress ,Signal Transduction - Abstract
Ethnopharmacological relevance The fruit of Schisandra chinensis (Turcz.) Baill, has been traditionally used in management of liver diseases and ageing associated neurodegeneration. The bioactive compound from this medicinal plant would be valuable for its potential use in prevention and treatment of Parkinson׳s disease. Aim of the study The overall objective of the present study was to understand the neuroprotective effect of schisantherin A, a dibenzocyclooctadiene lignan from the fruit of S. chinensis (Turcz.) Baill, and to elucidate its underlying mechanism of action. Material and methods This study investigated the protective effect of schisantherin A against selective dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA)-induced neural damage in human neuroblastoma SH-SY5Y cells and zebrafish models. Oxidative stress and related signaling pathways underlying the neuroprotective effect were determined by multiple biochemical assays and Western blot. Results Pretreatment with schisantherin A offered neuroprotection against 6-OHDA-induced SH-SY5Y cytotoxicity. Moreover, schisantherin A could prevent 6-OHDA-stimulated dopaminergic neuron loss in zebrafish. Our mechanistic study showed that schisantherin A can regulate intracellular ROS accumulation, and inhibit NO overproduction by down-regulating the over-expression of iNOS in 6-OHDA treated SH-SY5Y cells. Schisantherin A also protects against 6-OHDA-mediated activation of MAPKs, PI3K/Akt and GSK3β. Conclusion These findings demonstrate that schisantherin A may have potential therapeutic value for neurodegenerative diseases associated with abnormal oxidative stress such as Parkinson׳s disease.
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- 2015
6. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways
- Author
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Zhang, Lun Qing, primary, Sa, Fei, additional, Chong, Cheong Meng, additional, Wang, Ying, additional, Zhou, Zhong Yan, additional, Chang, Raymond Chuen Chung, additional, Chan, Shun Wan, additional, Hoi, Pui Man, additional, and Yuen Lee, Simon Ming, additional
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- 2015
- Full Text
- View/download PDF
7. Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats
- Author
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Wu, Jianhong, primary, Liu, Xingxian, additional, Chan, Chi-on, additional, Mok, Daniel K.W., additional, Chan, Shun-wan, additional, Yu, Zhiling, additional, and Chen, Sibao, additional
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- 2014
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- View/download PDF
8. Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines
- Author
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Tin-Yan Leung, Peter H. Yu, Shun Wan Chan, Mei-Kuen Chung, Wing-Yan Li, and De-Jian Guo
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Lung Neoplasms ,Tetrazolium Salts ,Apoptosis ,Breast Neoplasms ,Adenocarcinoma ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,Medicine ,Humans ,Fragmentation (cell biology) ,Rheum ,Pharmacology ,A549 cell ,biology ,Traditional medicine ,Dose-Response Relationship, Drug ,business.industry ,biology.organism_classification ,Molecular biology ,Antineoplastic Agents, Phytogenic ,Comet assay ,Thiazoles ,chemistry ,MCF-7 ,Rheum officinale ,DNA fragmentation ,Growth inhibition ,business ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
Ethnopharmacological relevance Rheum officinale Baill. (Da Huang) is one of the herbs commonly used in traditional Chinese medicine formulae against cancer. The traditional decoction is similar to the water extract used in the present study. Aim of the study The water extract of Da Huang was investigated to see if it possesses anticancer effects through apoptotic pathways. Materials and methods Human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines were treated with different concentrations of Da Huang water extract at different time intervals. Growth inhibition was detected by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] and colony formation assays; apoptosis was detected by cell morphologic analysis, DNA fragmentation analysis and COMET assay. Results Da Huang water extract was found to have significant growth inhibitory effects on both A549 and MCF-7 cell lines with IC 50 values 620 ± 12.7 and 515 ± 10.1 μg/ml, respectively. Growth inhibitory effects were dose- and time-dependent. A significant decrease in cell number, DNA fragmentation and single DNA strand breakages were observed in the Da Huang water extract treated A549 and MCF-7 cells. Conclusions This suggests that the water extract of Da Huang exerts potential anticancer activity through growth inhibition and apoptosis on MCF-7 and A549 cells lines.
- Published
- 2008
9. Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review
- Author
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Ng, Yam-Fung, primary, Tang, Philip Chiu-Tsun, additional, Sham, Tung-Ting, additional, Lam, Wing-Sum, additional, Mok, Daniel Kam-Wah, additional, and Chan, Shun-Wan, additional
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- 2014
- Full Text
- View/download PDF
10. Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review.
- Author
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Yam-Fung Ng, Chiu-Tsun Tang, Philip, Tung-Ting Sham, Wing-Sum Lam, Kam-Wah Mok, Daniel, and Shun-Wan Chan
- Subjects
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AMINO acids , *ANTIOXIDANTS , *ASTRAGALUS membranaceus , *CARDIOVASCULAR diseases , *DIABETES , *DRUG toxicity , *FATTY acids , *FLAVONOIDS , *HERBAL medicine , *CHINESE medicine , *POLYSACCHARIDES , *TUMORS , *PHYTOCHEMICALS , *THERAPEUTICS - Abstract
Ethnopharmacological relevance Semen Astragali Complanati (SAC), the dried ripe seed of Flatstem Milkvetch (Astragalus complanatus Bunge) (Leguminosae), is commonly used in traditional Chinese medicine (TCM) for treating muscle, liver, kidney, blood, skin and reproductive system diseases. Materials and methods Relevant information about SAC was gathered via "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect", "Medline Plus", "ACS", "CNKI" and "Wiley Online Library" and from books in local libraries. Results The major contents of SAC include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements. Previous scientific studies have reported that SAC exhibits a number of therapeutic effects on chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers. It has been found that flavonoids are the main bioactive component in SAC. However most of the previous studies have shown the effects brought by the total flavonoid fraction extracted from SAC only; further studies are warranted for the biological effects produced by individual components. There are only a few studies on the toxicity of SAC and the overall results show that its toxicity is quite low or even non-existent. Conclusions SAC is a valuable TCM herb with multiple pharmacological effects for treating some chronic diseases. More studies on SAC will help us to have a better understanding of its pharmacological mechanisms so as to provide more scientific evidence to explain its traditional uses, identify its therapeutic potential on other diseases and understand its possible harmful effects. Based on previous studies, it is easy to identify that antioxidant effect of SAC might play an important role on its pharmacological effects. Studying the effects of SAC on handling intracellular reactive oxygen species may be a potential direction to help understanding the molecular mechanisms of SAC on preventing and/or treating chronic diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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