21 results on '"Ticona, A."'
Search Results
2. Anti-inflammatory effects of TNF-α and ASK1 inhibitory compounds isolated from Schkuhria pinnata used for the treatment of dermatitis
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Apaza Ticona, Luis, Hervás Povo, Belén, Sánchez Sánchez-Corral, Javier, and Rumbero Sánchez, Ángel
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- 2024
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3. Diterpenes of Pinus pinaster aiton with anti-inflammatory, analgesic, and antibacterial activities
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Michavila Puente-Villegas, Santiago, Apaza Ticona, Luis, Rumbero Sánchez, Ángel, and Acebes, José-Luis
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- 2024
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4. Anti-inflammatory properties of Neowerdermannia vorwerkii Frič ‘Achacana’ used in treating stomach-related ailments
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Apaza Ticona, Luis, Rumbero Sánchez, Ángel, Humanes Bastante, Marcos, Serban, Andreea Madalina, and Hernáiz, María J.
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- 2022
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5. Wound healing, anti-inflammatory and anti-melanogenic activities of ursane-type triterpenes from Semialarium mexicanum (Miers) Mennega
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Apaza Ticona, Luis, Slowing, Karla, Serban, Andreea Madalina, Humanes Bastante, Marcos, and Hernáiz, María J.
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- 2022
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6. Isolation and characterisation of antibacterial and anti-inflammatory compounds from Gnaphalium polycaulon
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Apaza Ticona, L., Puerto Madorrán, M.J., Hervás Povo, B., Ortega Domenech, M., and Rumbero Sánchez, A.
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- 2022
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7. Anti-inflammatory, pro-proliferative and antimicrobial potential of the compounds isolated from Daemonorops draco (Willd.) Blume
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Apaza Ticona, L., Rumbero Sánchez, Á., Sánchez Sánchez-Corral, J., Iglesias Moreno, P., and Ortega Domenech, M.
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- 2021
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8. Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV–1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF–κB pathway
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Apaza Ticona, L., Bermejo, P., Guerra, J.A., Abad, M.J., Beltrán, M., Martín Lázaro, R., Alcamí, J., and Bedoya, L.M.
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- 2020
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9. Local/traditional uses, secondary metabolites and biological activities of Mashua (Tropaeolum tuberosum Ruíz & Pavón)
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Apaza Ticona, Luis Nestor, Tena Pérez, Victor, and Bermejo Benito, Paulina
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- 2020
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10. Anti-inflammatory properties of Neowerdermannia vorwerkii Frič ‘Achacana’ used in treating stomach-related ailments
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Ticona, Luis Apaza, primary, Sánchez, Ángel Rumbero, additional, Bastante, Marcos Humanes, additional, Serban, Andreea Madalina, additional, and Hernáiz, María J., additional
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- 2022
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11. Wound healing, anti-inflammatory and anti-melanogenic activities of ursane-type triterpenes from Semialarium mexicanum (Miers) Mennega
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Ticona, Luis Apaza, primary, Slowing, Karla, additional, Serban, Andreea Madalina, additional, Bastante, Marcos Humanes, additional, and Hernáiz, María J., additional
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- 2022
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12. Wound healing, anti-inflammatory and anti-melanogenic activities of ursane-type triterpenes from Semialarium mexicanum (Miers) Mennega
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Luis Apaza Ticona, Karla Slowing, Andreea Madalina Serban, Marcos Humanes Bastante, and María J. Hernáiz
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Pharmacology ,Melanins ,Wound Healing ,Plant Extracts ,Anti-Inflammatory Agents ,Melanoma, Experimental ,Celastraceae ,Triterpenes ,Inhibitory Concentration 50 ,Mice ,RAW 264.7 Cells ,Cell Line, Tumor ,Drug Discovery ,NIH 3T3 Cells ,Animals ,Medicine, Traditional - Abstract
The bark of Semialarium mexicanum commonly known as 'Cancerina' is used as an infusion in Central America and Mexico to treat various wound infections, as well as skin and vaginal ulcers.This study aimed to determine the wound healing, anti-inflammatory and anti-melanogenic activities of the aqueous extract of Semialarium mexicanum and to identify the compounds related to these activities.A bio-guided isolation of the active compounds of Semialarium mexicanum was carried out, selecting the sub-extracts and fractions depending on their wound healing, anti-inflammatory and anti-melanogenic activities in the RAW 264.7, NIH/3T3 and B16-F10 cells.Three compounds were obtained and characterised by nuclear magnetic resonance and mass spectrometry. These compounds are (3β)-3-Hydroxy-urs-12-en-28-oic acid (1), (3β)-Urs-12-ene-3,28-diol (2) and (2α, 19α)-2,19-Dihydroxy-3-oxo-urs-12-en-28-oic acid (3). Regarding the anti-inflammatory activity, the three compounds inhibited the production of NF-κB and NO, however, compound 3 was the most active with ICThe wound healing, anti-inflammatory and anti-melanogenic activity of the aqueous extract of Semialarium mexicanum was tested and analysed in the present study, after having isolated three ursane-type triterpenes.
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- 2021
13. Isolation and characterisation of antibacterial and anti-inflammatory compounds from Gnaphalium polycaulon
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L. Apaza Ticona, M. Ortega Domenech, M.J. Puerto Madorrán, A. Rumbero Sánchez, and B. Hervás Povo
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Gnaphalium ,medicine.drug_class ,Anti-Inflammatory Agents ,medicine.disease_cause ,Anti-inflammatory ,Microbiology ,Haemophilus influenzae ,Cell Line ,Moraxella catarrhalis ,Drug Discovery ,Streptococcus pneumoniae ,medicine ,Humans ,Pharmacology ,biology ,Bacteria ,Dose-Response Relationship, Drug ,Molecular Structure ,Chemistry ,Plant Extracts ,Epithelial Cells ,Fibroblasts ,Plant Components, Aerial ,biology.organism_classification ,Gnaphalium polycaulon ,Anti-Bacterial Agents ,Staphylococcus aureus ,Ofloxacin ,Antibacterial activity ,medicine.drug - Abstract
Ethno-pharmacological relevance Gnaphalium polycaulon commonly known as “cudweed” has been used throughout South America as an infusion to treat colds, bronchitis, fever or pneumonia. Aim of the study This study aimed to determine the antibacterial and anti-inflammatory activities of the aqueous extract of Gnaphalium polycaulon and identify the related compounds. Materials and methods A bio-guided isolation of the active compounds of Gnaphalium polycaulon was carried out, selecting the fractions depending on their antibacterial, anti-inflammatory and cytotoxic activities. The antibacterial effect was studied against Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Streptococcus pneumoniae; and the anti-inflammatory study was performed by measuring the inhibition of NF-κB in BEAS-2B and IMR-90 cell cultures. Results Three compounds were obtained and characterised by nuclear magnetic resonance and mass spectrometry. These compounds are 2-(4-(1-H-tetrazol-1-yl) phenyl)-2-aminopropanoic acid (1), N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide (2) and N-(4-ethoxyphenyl)-4-(2-methylimidazo-[1,2-α] pyridine-3-yl) thiazol-2-amine (3). All compounds showed antibacterial activity with MIC values of 44.80–44.85, 0.017–0.021 and 0.0077–0.0079 μM, respectively, in the Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Streptococcus pneumoniae strains, while the positive control, Ofloxacin, had a MIC value of 27.64–27.67 μM. This was corroborated through a zone inhibition assay, where compound 3 (11.36–11.67 mm) was much more active than the positive control (Ofloxacin, 23.41–24.12 mm), while compounds 2 (26.47–27.64 mm) and 1 (28.39–29.76 mm) displayed similar antibacterial potential to the positive control. Finally, all the compounds presented NF-κB inhibitory activity, compounds 3 (IC50 = 0.0071–0.0073 μM) and 2 (IC50 = 0.016–0.019 μM) being the most promising. Compound 1 (IC50 = 44.24–44.26 μM) had less anti-inflammatory potential, being also the closest to the values displayed by the positive control (Celastrol, IC50 = 7.41 μM). Conclusion In the present study, three compounds were isolated for the first time from the aqueous extract of Gnaphalium polycaulon. Their antibacterial and anti-inflammatory potential was tested and showcased.
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- 2021
14. Hydroalcoholic extract of Tagetes minuta L. inhibits inflammatory bowel disease through the activity of pheophytins on the NF-κB signalling pathway
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Apaza Ticona, Luis, Lacheva, Ginka Ilieva, Serban, Andreea Madalina, and Rumbero Sánchez, Ángel
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- 2021
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15. Anti-inflammatory properties of Neowerdermannia vorwerkii Frič ‘Achacana’ used in treating stomach-related ailments
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Luis Apaza Ticona, Ángel Rumbero Sánchez, Marcos Humanes Bastante, Andreea Madalina Serban, and María J. Hernáiz
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Pharmacology ,Oxadiazoles ,Plant Extracts ,Stomach ,Drug Discovery ,Anti-Inflammatory Agents ,Cytokines - Abstract
The tuber of Neowerdermannia vorwerkii commonly known as 'Achacana' is used as an infusion in Andean countries to treat various gastrointestinal ailments, kidney and liver diseases.This study determined the anti-inflammatory activity of the aqueous extract from Neowerdermannia vorwerkii and identified the compounds related to this activity.A bio-guided isolation of the active compounds of Neowerdermannia vorwerkii was carried out, selecting the sub-extracts and fractions depending on their anti-inflammatory activity in the Hs 738.St/Int, Hs 746T and NCI-N87 cells.Three compounds were obtained and characterised by nuclear magnetic resonance and mass spectrometry. These compounds are (3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (3). Regarding their anti-inflammatory activity, the three compounds inhibited the production of cytokines (IL-1β, IL-6 and TNF-α), however, compound 1 was the most active, with an ICIn the present study, the anti-inflammatory activity of the aqueous extract of Neowerdermannia vorwerkii was tested and analysed, following the isolation of three 1,2,4-oxadiazoles type compounds with similar pharmacological properties.
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- 2022
16. Hydroalcoholic extract of Tagetes minuta L. inhibits inflammatory bowel disease through the activity of pheophytins on the NF-κB signalling pathway
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Luis Apaza Ticona, Andreea Madalina Serban, Ángel Rumbero Sánchez, Ginka Ilieva Lacheva, and UAM. Departamento de Química Orgánica
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Pheophytin ,medicine.drug_class ,Anti-Inflammatory Agents ,NF-κB ,Anti-inflammatory ,Cell Line ,Tagetes ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,food ,Drug Discovery ,medicine ,Humans ,IC50 ,030304 developmental biology ,Pharmacology ,Tagetes minuta ,0303 health sciences ,Traditional medicine ,Dose-Response Relationship, Drug ,Ethanol ,Plant Extracts ,Stomach ,Pheophytins ,NF-kappa B ,Water ,Química ,Inflammatory Bowel Diseases ,In vitro ,food.food ,medicine.anatomical_structure ,chemistry ,Cell culture ,TNF-α ,030220 oncology & carcinogenesis ,Signal Transduction - Abstract
Ethno-pharmacological relevance: Species of the genus Tagetes are well known for their anti-inflammatory properties. Tagetes minuta “Huacatay” is an endemic species of South America that has been used in traditional medicine since ancient times as a remedy for stomach and intestinal discomfort. Aim of the study: The aim of this study is to investigate the anti-inflammatory activity of the aqueous and hydroalcoholic extracts of the Huacatay, identifying the compounds responsible for this activity. Materials and methods: Anti-inflammatory activity of the compounds, fractions and extracts was evaluated in Hs 746T (stomach), HIEC-6 (intestine) and THP-1 (monocytes peripheral blood) cells by measuring their inhibitory capacity against the NF-κB production. Results: Aqueous and hydroalcoholic extracts of Tagetes minuta displayed anti-inflammatory activity in vitro, the hydroalcoholic extract being the most active (IC50 between 59.72 and 66.42 μg/mL) in all cell lines. Bio-guided hydroalcoholic extract fractionation led to the isolation and characterisation of two pheophytins, pheophytin a (1) and 132-hydroxy pheophytin a (2). Both compounds inhibited the production of NF-κB with IC50 values in the low micromolar range, with an IC50 between 12.32 and 16.01 μM for compound 1 and 7.91–9.87 μM for compound 2. Conclusions: The two pheophytins isolated in this study inhibit the production of NF-κB, thus showing that the traditional anti-inflammatory use of Tagetes minuta can be proved through pharmacological assays. This contributes to understanding the anti-inflammatory activity of the Huacatay extracts and their use in the treatment of stomach and intestinal discomfort, This work was supported by the National Herbarium of Bolivia and the Fundación de la Universidad Autónoma de Madrid (FUAM)
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- 2020
17. Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV–1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF–κB pathway
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Luis-Miguel Bedoya, J. A. Guerra, José Alcamí, Manuela Beltrán, Paulina Bermejo, L. Apaza Ticona, R. Martín Lázaro, M. J. Abad, UAM. Departamento de Química Orgánica, Agencia Española de Cooperación Internacional para el Desarrollo, Complutense University of Madrid (España), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), and Red de Investigación Cooperativa en Investigación en Sida (España)
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natural products ,Artemisia annua ,Artemisia campestris ,Pharmacology ,Field wormwood ,Virus Replication ,Antiviral Agents ,Article ,Terpene ,03 medical and health sciences ,0302 clinical medicine ,field wormwood ,Viral entry ,Drug Discovery ,medicine ,Humans ,IC50 ,antiretrovirals ,030304 developmental biology ,Flavonoids ,0303 health sciences ,Natural products ,biology ,Dose-Response Relationship, Drug ,Ethanol ,Chemistry ,Plant Extracts ,Terpenes ,NF-kappa B ,Antiretrovirals ,HIV ,NF–κB ,Química ,Plant Components, Aerial ,biology.organism_classification ,In vitro ,HEK293 Cells ,Mechanism of action ,Artemisia ,030220 oncology & carcinogenesis ,HIV-1 ,medicine.symptom ,Signal Transduction - Abstract
Ethno–pharmacological relevance The genus Artemisia spp. is well known for its anti–infectious properties and its high content in anti–infectious compounds, like the well–known sweet wormwood (Artemisia annua L.). Another Artemisia species, Artemisia campestris subsp. glutinosa (Besser) Batt., field wormwood, has been traditionally used as medicinal plant in the Mediterranean region. Aim of the study The aim of this study is to investigate the anti–HIV activity of field wormwood, to identify the compounds responsible for this activity and their structure and mechanism of action. Materials and methods Antiviral activity of isolated compounds and extracts was evaluated in HIV–1 infections of lymphoblastoid cells. We also evaluated the mechanism of action of isolated compounds. Viral entry was studied comparing the inhibitory effect of isolated compounds on wild type HIV–1 and VSV pseudotyped HIV–1. To assess the viral transcriptional effect, plasmids encoding luciferase reporter genes under the control of the whole genome of HIV–1 or NF–κB or Sp1 transcription factors were transfected in the presence of the compounds under evaluation. Finally, antioxidant activity was assessed by quantitation of reduced and total glutathione in treated cell cultures. Results Ethanolic and aqueous extracts of Artemisia campestris subsp. glutinosa (Besser) Batt. subsp. glutinosa displayed anti–HIV activity in vitro, although ethanolic extract was more powerful (IC50 14.62 μg/mL). Bio–guided ethanolic extract fractionation leads to the isolation and characterization of two terpenes, damsin and canrenone, and four flavonoids, 6, 2’, 4’–trimethoxyflavone, acerosin, cardamonin and xanthomicrol. All the isolated compounds inhibited HIV–1 replication in vitro with IC50 values between the middle nanomolar and the low micromolar range. Their anti–HIV mechanism of action is due to the bloking of viral entry and/or transcription inhibition, without correlation with the antioxidant activity, through interference with the cellular transcription factors NF–κB and Sp1, which are targets that are not currently reached by antiretroviral therapy. Conclusion We describe here the anti–HIV activity of field wormwood, Artemisia campestris subsp. glutinosa (Besser) Batt., and the isolation and study of the mechanism of action of two terpenes and four flavonoids, responsible, at least in part, for its activity, through the inhibition of two different cellular targets affecting the HIV replication cycle. The activity of these compounds in cellular targets could explain why plant extracts can be used in the treatment of different diseases. Besides, the presence of several compounds with dual and different mechanisms of action could prove useful in the treatment of HIV–1 infection, since it could aid to overcome drug resistances and simplify drug therapy. This work is a further step in understanding the anti–infectious activity of wormwood species and their use in treating infectious diseases., Graphical abstract Image 1, Highlights • Artemisia campestris subsp. glutinosa (Besser) Batt. ethanolic and aqueous extracts inhibit HIV–1 replication in vitro. • Two terpenes, damsin and canrenone, and four flavonoids, 6,2’,4’–trimethoxyflavone, acerosin, cardamonin and xanthomicrol have been isolated from the active anti–HIV fractions. • Acerosin and xanthomicrol inhibit viral entry while damsin, canrenone, 6, 2’, 4’–trimethoxyflavone and xanthomicrol, and also acerosin, show activity in HIV–1 transcription. • Flavonoids displayed also an antioxidant effect which showed no correlation with the transcriptional activity. • All the isolated compounds acted through cellular targets, cellular receptors and transcription factors, suggesting their potential involvement in other diseases.
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- 2020
18. Leishmanicidal and cytotoxic activity from plants used in Tacana traditional medicine (Bolivia)
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Alcides Serato, Diandra Arévalo-Lopéz, Olov Sterner, Abigail Limachi, Alberto Giménez, Crispín Paredes, Ivan Limachi, Enrique Udaeta, Boris Espinoza, Ninoska Flores, Juan C. Ticona, Nelida Nina, Efrain Salamanca, David Garnica, Sarah Salazar, and Dayana Coaquira
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Bolivia ,Cell Survival ,01 natural sciences ,High-performance liquid chromatography ,Leishmania braziliensis ,Lethal Dose 50 ,HeLa ,Parasitic Sensitivity Tests ,Drug Discovery ,medicine ,Maceration (wine) ,Humans ,Cytotoxicity ,Medicinal plants ,Pharmacology ,Plants, Medicinal ,Ethanol ,biology ,Traditional medicine ,Plant Extracts ,010405 organic chemistry ,Chemistry ,Leishmaniasis ,Reversed-phase chromatography ,biology.organism_classification ,medicine.disease ,Leishmania ,Trypanocidal Agents ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Solvents ,Medicine, Traditional ,HeLa Cells ,Phytotherapy - Abstract
Etnopharmacological relevance Thirty-eight Tacana medicinal plant species used to treat skin problems, including leishmania ulcers, skin infections, inflammation and wound healing, were collected in the community of Buena Vista, Bolivia, with the Tacana people. Twenty two species are documented for the first time as medicinal plants for this ethnic group living in the northern area of the Department of La Paz. Aim of the study To evaluate the leishmanicidal effect (IC50) and cytotoxicity (LD50) of the selected plants. To carry out bioguided studies on the active extracts. To assess the potential of Bolivian plant biodiversity associated with traditional knowledge in the discovery of alternative sources to fight leishmaniasis. Materials and methods Seventy three ethanol extracts were prepared from 38 species by maceration and were evaluated in vitro against promastigotes of Leishmania amazonensis and L. braziliensis. Active extracts (IC50 ≤ 50 μg/mL) were fractionated by chromatography on Silica gel column and the fractions were assessed against the two Leishmania strains. The most active fractions and the crude extracts were evaluated against reference strains of L. amazonensis, L. braziliensis, L. aethiopica, two native strains (L. Lainsoni and L. braziliensis) and for cytotoxicity against HeLa cells. The chromatographic profile of the active fractions was obtained by reverse phase chromatography using HPLC. Results From the 73 extracts, 39 extracts (53.4%) were inactive and 34 showed activity. Thirteen species were sselected for bioguided studies. The crude extracts and their 36 fractions were evaluated against two Leishmania strains. The most active fraction were tested in a panel of five leishmania strains and for cytotoxicity. The Selective Index (SI = LD50/IC50) was calculated, and were generally low. Retention time and UV spectra were recorded for the active fractions by HPLC-DAD using a reverse phase column. Profiles were very different from each other, showing the presence of different compounds. Conclusion Bolivian traditional knowledge from the Tacanba was useful to identify plants with effect on Leishmania promastigotes. Chromatographic bioguided studies showed stronger leishmanicidal and cytotoxic activity for the medium polar fraction. HPLC analysis showed different chromatographic profiles of the active fractions.
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- 2018
19. Local/traditional uses, secondary metabolites and biological activities of Mashua (Tropaeolum tuberosum RuízPavón)
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Paulina Bermejo Benito, Luis Apaza Ticona, and Víctor Tena Pérez
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Hydroxybenzoic acid ,Research groups ,Web of science ,medicine.drug_class ,Anti-Inflammatory Agents ,Anti-inflammatory ,Antioxidants ,03 medical and health sciences ,0302 clinical medicine ,Consumer society ,Tropaeolum ,Tropaeolum tuberosum ,Drug Discovery ,medicine ,Humans ,030304 developmental biology ,Pharmacology ,0303 health sciences ,biology ,Traditional medicine ,Plant Extracts ,food and beverages ,South America ,biology.organism_classification ,Anti-Bacterial Agents ,Plant Tubers ,030220 oncology & carcinogenesis ,Ethnopharmacology ,Relevant information - Abstract
Ethnopharmacological relevance Tropaeolum tuberosum Ruiz & Pavon (Tropaeolaceae). Sim (commonly called Mashua) is an indigenous plant that has medicinal values for various ethnic groups of the regions of the Andes mountain range of South America, which use it for the treatment of diseases venereal, lung and skin; for the healing of internal and external wounds; and as an analgesic for kidney and bladder pain. Aim of the review: We critically summarised the current evidence on the botanic characterisation and distribution, ethnopharmacology, secondary metabolites, pharmacological activities, qualitative and quantitative analysis, and toxicology of T. tuberosum. Materials and methods The relevant information on T. tuberosum was gathered from worldwide accepted scientific databases via electronic search (Google scholar, Elsevier, SciFinder, ScienceDirect, PubMed, SpringerLink, Web of Science, Scopus, Wiley Online, Mendeley, Scielo and Dialnet electronic databases). Information was also obtained from the literature and books as well as PhD and MSc dissertations. Plant names were validated by ‘The Plant List’ ( www.theplantlist.org ). Results T. tuberosum has diverse uses in local and popular medicine, specifically for relieving pain and infections in humans. Regarding its biological activities, polar extracts (aqueous, hydroalcoholic) and isolated compounds from the tubers have exhibited a wide range of in vitro and in vivo pharmacological effects, including antibacterial, antioxidant, anti-inflammatory activities. Quantitative analysis (e.g., NMR, HPLC, GC-MS) indicated the presence of a set of secondary metabolites, including hydroxybenzoic acids, tannins, flavanols, anthocyanins, glucosinolates, isothiocyanates, phytosterols, fatty acids and alkamides in the tubers of T. tuberosum. Likewise, glucosinolates have been identified in the seeds and isothiocyanates have been detected in leaves, flowers and seeds. Conclusions T. tuberosum has been tested for various biological activities and the extracts (tubers in particular) demonstrated a promising potential as an antibacterial, antioxidant, anti-inflammatory and inhibitors of benign prostatic hyperplasia. A lack of alignment between the ethno-medicinal uses and existing biological screenings was observed, indicating the need to explore its potential for the treatment against respiratory affections, urinary affections and blood diseases. Likewise, it is necessary to analyse deeply the relationship that exists between the different tuber colours of T. tuberosum and its use for the treatment of certain diseases. Validation of clinical studies of the antibacterial, antioxidant/anti-inflammatory, anti-spermatogenic activities and as inhibitors of benign prostatic hyperplasia is required. Moreover, studies on the toxicity, bioavailability, and pharmacokinetics, in addition to clinical trials, are indispensable for assessing the safety and efficacy of the active metabolites or extracts obtained from T. tuberosum. Other areas that need investigation are the development of future applications based on their active metabolites, such as neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease). Finally, the work purposes to motivate other research groups to carry out a series of scientific studies that can fill the gaps that exist with respect to Mashua properties, and thus be able to change the focus of T. tuberosum (Mashua) that currently has in the consumer society.
- Published
- 2019
20. Anti-inflammatory, pro-proliferative and antimicrobial potential of the compounds isolated from Daemonorops draco (Willd.) Blume
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L. Apaza Ticona, A. Rumbero Sánchez, P. Iglesias Moreno, M. Ortega Domenech, J. Sánchez Sánchez-Corral, and UAM. Departamento de Química
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Staphylococcus aureus ,medicine.drug_class ,Anti-Inflammatory Agents ,Wound healing ,Microbial Sensitivity Tests ,Anti-inflammatory ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Anti-Infective Agents ,Drug Discovery ,Escherichia coli ,Dragon's blood ,medicine ,Animals ,Humans ,Bioassay ,IC50 ,Cell Proliferation ,030304 developmental biology ,EC50 ,Pharmacology ,Daemonorops ,0303 health sciences ,Traditional medicine ,Plant Extracts ,Taspine ,Química ,Antimicrobial ,Corpus albicans ,HaCaT ,Pro-proliferative ,chemistry ,030220 oncology & carcinogenesis ,NIH 3T3 Cells - Abstract
Ethno-pharmacological relevance Daemonorops draco (D. draco) commonly known as “Dragon's blood” is one of the most used plants by Momok, Anak Dalam and Talang Mamak tribes from Indonesia as a remedy for wound healing. Aim of the study: This study aimed to identify the extract, fractions and compounds responsible for the anti-inflammatory and pro-proliferative activities of the D. draco resin. Additionally, the antimicrobial activity against two bacteria and one yeast species was analysed. Materials and methods Bio-guided isolation of compounds with anti-inflammatory, pro-proliferative and antimicrobial activities from the D. draco resin was carried out by measuring: the inhibition of NF-κB and activation of Nrf2 in THP-1, HaCaT, NIH-3T3 cells; cell proliferation in NIH-3T3 and HaCaT cells; and the antimicrobial effect on E. coli, S. aureus and C. albicans. Results Guided isolation by bioassay gave rise to the isolation and characterisation by nuclear magnetic resonance and mass spectrometry of three compounds: 1 (Bexarotene), 2 (Taspine) and 3 (2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone). All compounds showed NF-κB inhibitory activity with IC50 values of 0.10–0.13, 0.22–0.24 and 3.75–4.78 μM, respectively, while the positive control, Celastrol, had an IC50 of 7.96 μM. Likewise, all compounds showed an activating effect of Nrf2 with EC50 values of 5.34–5.43, 163.20–169.20 and 300.82–315.56 nM, respectively, while the positive control, CDDO-Me, had an EC50 of 0.11 nM. In addition, concerning the pro-proliferative activity, compound 1 (IC50 = 8.62–8.71 nM) showed a capacity of 100%, compound 2 (IC50 = 166–171 nM) showed a capacity of 75%, and compound 3 (IC50 = 469–486 nM) showed a capacity of 65%, while FSB 10% (positive control) had a pro-proliferative activity of 100% in the NIH3T3 cell lines (fibroblasts) and HaCaT (keratinocytes). Finally, all the compounds showed antimicrobial activity with MIC values of 0.12–0.16, 0.31–0.39 and 3.96–3.99 μM, respectively, in S. aureus, E. coli and C. albicans strains, while the positive control, Ofloxacin, had a MIC of 27.65 μM. Conclusion This study managed to isolate, for the first time, three compounds (Bexarotene, Taspine and 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone) from the resin of D. draco, with anti-inflammatory, and pro-proliferative as well as antimicrobial activities.
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- 2021
21. Leishmanicidal and cytotoxic activity from plants used in Tacana traditional medicine (Bolivia)
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Arévalo-Lopéz, Diandra, primary, Nina, Nélida, additional, Ticona, Juan C., additional, Limachi, Ivan, additional, Salamanca, Efrain, additional, Udaeta, Enrique, additional, Paredes, Crispin, additional, Espinoza, Boris, additional, Serato, Alcides, additional, Garnica, David, additional, Limachi, Abigail, additional, Coaquira, Dayana, additional, Salazar, Sarah, additional, Flores, Ninoska, additional, Sterner, Olov, additional, and Giménez, Alberto, additional
- Published
- 2018
- Full Text
- View/download PDF
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