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Nonrepresentative estimates indicate that 25%-50% of transgender people are parents. Yet very little is known about their demographic characteristics and health outcomes. The present study compared the quality of life and several mental health (i.e., psychological distress, life satisfaction, happiness, social well-being) and health (i.e., physical health, alcohol and drug use) dimensions by gender identity and parenthood status in a probability sample of 1,436 transgender and cisgender respondents to the U.S. Transgender Population Health Survey (TransPop study). An estimated 18.8% of transgender respondents were parents, with the majority (52.5%) being transgender women. After controlling for age, education, and relationship status, there were no significant differences between trans- and cisgender parents and their nonparent counterparts on any mental health or health dimensions. These findings are important to family practitioners and policymakers so that they do not mistakenly assume that any problems transgender parents may report reveal their unsuitability to parent. Rather, because differences in health outcomes were seen only across gender identities, such problems are more likely related to stigma and discrimination experiences in a cisgenderist/heterosexist society. (PsycInfo Database Record (c) 2021 APA, all rights reserved). [ABSTRACT FROM AUTHOR]