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Aims The objective of the current study was to investigate the effects of three commercial prebiotics including A-Max, Celmanax, and A-Max Ultra (each of them 0.5, 1, and 1.5g/kg diets) on growth, feed performance, and blood biochemical compounds of beluga juvenile. Materials & Methods 900 fish with an average weight of 21.5±0.89g were feed in 9 treatments (with three replicate) for 60 days. Control treatment was without supplementation. Fish were fed to satiation triple daily of 5% body weight. At the end of this period, the feed and growth performance were measured. Findings There was a significantly higher final body weight in A-Max ultra 0.5g/kg (90.00±21.78g) compared with control (37.50±9.60g). The highest and the lowest of food conversion were in control and A-Max ultra 0.5g/kg treatments, respectively. The results showed that the highest fat and protein efficiency ratio was obtained in prebiotic treatment (A-Max ultra 0.5g/kg) as 2.19±0.77 and 7.37±2.60 and the lowest was obtained in control. Generally, the best treatments were in groups of Celmanax (dose of 0.5g/kg), A-Max (dose of 1.5g/kg), and A-Max Ultra (0.5g/kg). In addition, after determining the proper dose, blood samples of fish were collected in the above-mentioned treatments. Based on the results of blood biochemistry parameters, there were no significant differences AST, ALP, and ALT activity, so that the highest amount was obtained in the control. Also, there were no significant differences in protein and cortisol experiment groups. Conclusion The use of prebiotics in juvenile sturgeon diet has positive effects on feed performance, liver enzymes, and blood biochemical parameters. [ABSTRACT FROM AUTHOR]