1. A Highly Selective Fluorescent Probe for Imaging Hydrogen Sulfide in Living HeLa Cells.
- Author
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Zhang, Wenshen, Xun, Qining, Xing, Wenfang, Xu, Feng, and Liu, Xia
- Subjects
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FLUORESCENT probes , *HELA cells , *HYDROGEN sulfide , *STOKES shift , *DISEASE progression , *RAW materials - Abstract
As an important endogenous gasotransmitter, hydrogen sulfide (H2S) has been implicated with a variety of biological processes and has attracted more and more attention for its key role in a wide range of pathological processes. However, lacking tools for H2S-specific in situ detection, the changes of endogenous H2S levels in the pathological progression of diseases are still unclear. In this work, a turn-on fluorescent probe (BF2-DBS) has been designed and synthesized by two-step reactions using 4-diethylaminosalicylaldehyde and 1,4-dimethylpyridinium iodide as raw materials. Probe BF2-DBS displays high selectivity and sensitivity to H2S with a large Stokes shift and good anti-interference ability. The practical application of probe BF2-DBS to detect endogenous H2S was evaluated in living HeLa cells. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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