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Your search keyword '"Ivan, Čapo"' showing total 2 results
Start Over Author "Ivan, Čapo" Journal journal of functional foods
2 results on '"Ivan, Čapo"'

1. Antioxidant and hepatoprotective potential of sweet basil (Ocimum basilicum L.) extract in acetaminophen-induced hepatotoxicity in rats

Author

Branislava Teofilović, Ana Tomas, Nikola Martić, Nebojša Stilinović, Milan Popović, Ivan Čapo, Nevena Grujić, Branislava Ilinčić, and Aleksandar Rašković

Subjects
Basil, Free radicals, Oxidative stress, Antioxidant enzymes, Acute liver injury, Nutrition. Foods and food supply, TX341-641
Abstract

This research aimed to examine the effects of pre-treatment with basil extract, prepared as an infusion, on acetaminophen-induced acute liver injury in rats. In vitro analysis of total phenolic, flavonoid content, and antioxidant activity was performed by spectrophotometric methods. Effects of basil extract on oxidative stress parameters, biochemical markers of liver injury, and liver morphology were determined in an in vivo model of acetaminophen-induced liver injury in Wistar rats. Total phenolic content was 52.61 ± 1.35 mg GAE/g of DE, and flavonoid content was 0.5 ± 0.2 mg QE/g of DE. IC50 values ranged from 0.22 to 45.76 μg/ml for DPPH radical, OH radical, H2O2 and lipid peroxidation. Ascorbic acid was used as a positive control. The extract lowered the intensity of lipid peroxidation and potentiated the activity of antioxidant enzymes. In addition, serum levels of aspartate aminotransferase and alanine aminotransferase were significantly lower in basil extract-treated animals in comparison to respective controls.

Published
2021
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2. Antioxidant and hepatoprotective potential of sweet basil (Ocimum basilicum L.) extract in acetaminophen-induced hepatotoxicity in rats

Author

Nikola Martić, Branislava Teofilović, Ivan Čapo, Milan Popović, Nevena Grujic, Ana Tomas, Branislava Ilincic, Aleksandar Rašković, and Nebojša Stilinović

Subjects
Antioxidant, DPPH, medicine.medical_treatment, Flavonoid, Medicine (miscellaneous), Free radicals, Pharmacology, Lipid peroxidation, Basil, chemistry.chemical_compound, food, medicine, Acute liver injury, TX341-641, Liver injury, chemistry.chemical_classification, Nutrition and Dietetics, biology, Nutrition. Foods and food supply, Sweet Basil, Ocimum, biology.organism_classification, medicine.disease, Ascorbic acid, food.food, chemistry, Oxidative stress, Antioxidant enzymes, Food Science
Abstract

This research aimed to examine the effects of pre-treatment with basil extract, prepared as an infusion, on acetaminophen-induced acute liver injury in rats. In vitro analysis of total phenolic, flavonoid content, and antioxidant activity was performed by spectrophotometric methods. Effects of basil extract on oxidative stress parameters, biochemical markers of liver injury, and liver morphology were determined in an in vivo model of acetaminophen-induced liver injury in Wistar rats. Total phenolic content was 52.61 ± 1.35 mg GAE/g of DE, and flavonoid content was 0.5 ± 0.2 mg QE/g of DE. IC50 values ranged from 0.22 to 45.76 μg/ml for DPPH radical, OH radical, H2O2 and lipid peroxidation. Ascorbic acid was used as a positive control. The extract lowered the intensity of lipid peroxidation and potentiated the activity of antioxidant enzymes. In addition, serum levels of aspartate aminotransferase and alanine aminotransferase were significantly lower in basil extract-treated animals in comparison to respective controls.

Published
2021

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