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Your search keyword '"SGLT1 expression"' showing total 3 results
Start Over Descriptor "SGLT1 expression" Journal journal of functional foods
3 results on '"SGLT1 expression"'

1. Rice (Oryza sativa japonica) albumin hydrolysates suppress postprandial blood glucose elevation by adsorbing glucose and inhibiting Na+-d-glucose cotransporter SGLT1 expression

Author

Shigenobu Ina, Aya Hamada, Hanae Nakamura, Yusuke Yamaguchi, Hitoshi Kumagai, and Hitomi Kumagai

Subjects
Rice albumin peptides, Rice protein, Oral glucose tolerance tests, Blood glucose, Glucose adsorption, SGLT1 expression, Nutrition. Foods and food supply, TX341-641
Abstract

The mechanism of the suppressive effect of rice albumin (RA) on postprandial hyperglycemia after glucose loading was investigated. In order to examine if small peptides derived from RA are responsible for prevention of postprandial hyperglycemia, RA was hydrolysed to indigestible high-molecular-weight peptides (HMP) and low-molecular-weight peptides (LMP) by trypsin, HMP and LMP being fractionated by gel-filtration chromatography. In oral glucose tolerance test (OGTT), both HMP and LMP suppressed the increase in blood glucose levels. In vitro diffusion test results showed that HMP adsorbed glucose and retarded its diffusion rate like dietary fibers. On the other hand, LMP suppressed the expression of sodium-dependent glucose transporter-1 (SGLT1) in STC-1 cells. Therefore, the suppressive effect of RA on postprandial hyperglycemia would be due to the dual actions of HMP and LMP. Our results demonstrated the potential use of RA as a functional food material to prevent diabetes.

Published
2020
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2. Rice (Oryza sativa japonica) albumin hydrolysates suppress postprandial blood glucose elevation by adsorbing glucose and inhibiting Na+-d-glucose cotransporter SGLT1 expression

Author

Hitoshi Kumagai, Shigenobu Ina, Hanae Nakamura, Yusuke Yamaguchi, Aya Hamada, and Hitomi Kumagai

Subjects
0301 basic medicine, medicine.medical_specialty, Rice protein, animal structures, endocrine system diseases, Rice albumin peptides, Medicine (miscellaneous), Hydrolysate, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, D-Glucose, Internal medicine, Diabetes mellitus, medicine, Blood glucose, TX341-641, 030109 nutrition & dietetics, Nutrition and Dietetics, Nutrition. Foods and food supply, Albumin, Glucose adsorption, SGLT1 expression, 04 agricultural and veterinary sciences, Oral glucose tolerance tests, Trypsin, medicine.disease, 040401 food science, In vitro, Endocrinology, Postprandial, chemistry, Cotransporter, Food Science, medicine.drug
Abstract

The mechanism of the suppressive effect of rice albumin (RA) on postprandial hyperglycemia after glucose loading was investigated. In order to examine if small peptides derived from RA are responsible for prevention of postprandial hyperglycemia, RA was hydrolysed to indigestible high-molecular-weight peptides (HMP) and low-molecular-weight peptides (LMP) by trypsin, HMP and LMP being fractionated by gel-filtration chromatography. In oral glucose tolerance test (OGTT), both HMP and LMP suppressed the increase in blood glucose levels. In vitro diffusion test results showed that HMP adsorbed glucose and retarded its diffusion rate like dietary fibers. On the other hand, LMP suppressed the expression of sodium-dependent glucose transporter-1 (SGLT1) in STC-1 cells. Therefore, the suppressive effect of RA on postprandial hyperglycemia would be due to the dual actions of HMP and LMP. Our results demonstrated the potential use of RA as a functional food material to prevent diabetes.

Published
2020
Full Text
View/download PDF

3. Rice (Oryza sativa japonica) albumin hydrolysates suppress postprandial blood glucose elevation by adsorbing glucose and inhibiting Na+-d-glucose cotransporter SGLT1 expression.

Author

Ina, Shigenobu, Hamada, Aya, Nakamura, Hanae, Yamaguchi, Yusuke, Kumagai, Hitoshi, and Kumagai, Hitomi

Abstract

• Rice albumin was digested to indigestible HMP (14 kDa) and LMP (<2 kDa) by trypsin. • HMP and LMP suppressed the blood glucose and insulin elevation in rats (OGTT). • HMP adsorbed glucose and retarded its diffusion rate like dietary fibers. • LMP suppressed the expression of sodium-dependent glucose transporter-1 (SGLT1). The mechanism of the suppressive effect of rice albumin (RA) on postprandial hyperglycemia after glucose loading was investigated. In order to examine if small peptides derived from RA are responsible for prevention of postprandial hyperglycemia, RA was hydrolysed to indigestible high-molecular-weight peptides (HMP) and low-molecular-weight peptides (LMP) by trypsin, HMP and LMP being fractionated by gel-filtration chromatography. In oral glucose tolerance test (OGTT), both HMP and LMP suppressed the increase in blood glucose levels. In vitro diffusion test results showed that HMP adsorbed glucose and retarded its diffusion rate like dietary fibers. On the other hand, LMP suppressed the expression of sodium-dependent glucose transporter-1 (SGLT1) in STC-1 cells. Therefore, the suppressive effect of RA on postprandial hyperglycemia would be due to the dual actions of HMP and LMP. Our results demonstrated the potential use of RA as a functional food material to prevent diabetes. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

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