1. Study of the antiaging effects of bird's nest peptide based on biochemical, cellular, and animal models
- Author
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Weijuan Bai, Xuncai Liu, Qunyan Fan, Jianmei Lian, and Baozhong Guo
- Subjects
Edible bird's nest ,Edible bird's nest peptide ,Hydrolysate ,Efficacy ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Aiming for antiaging functions, an edible bird's nest peptide (EBNP) was systematically evaluated. First, it was shown that the EBNP had 6.64% sialic acid, 68.89 g/100 g amino acid content. Subsequently, it was found that EBNP had antioxidant capacity, the DPPH•, ABTS+, and •OH scavenging IC50 values of EBNP were 1.08 mg/mL, 0.46 mg/mL, and 370.43 mg/mL, respectively, and the antioxidant EC50 value of EBNP in HaCaT cells was 14.14 mg/mL. The EBNP had melanin synthesis inhibitory capacity, the melanin synthesis inhibition EC50 value of EBNP in B16 cells was 1.48 mg/mL, and the melanin synthesis inhibition EC50 value of EBNP in zebrafish was 0.11 mg/mL. In addition, the EBNP showed anti-photoaging capacity in zebrafish and cell scratch repair and proliferation capacity in MRC-5 cells. It could be concluded that the EBNP had potential to be applied in functional foods, pharmaceuticals, and skin care products as an antiaging ingredient.
- Published
- 2023
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