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This investigation was aimed to explore the cardioprotective effect of Ramontchi fruits (Flacourtia indica; FI) in isoprenaline-administered Long-Evans rats. Administration of isoprenaline increased the total heart wet weight, MDA, NO, and APOP as well as ALT, AST, and CK-MB levels, which were normalized by FI fruits treatment. Moreover, expressions of antioxidant genes i.e., Nrf-2, HO-1, HO-2, SOD, catalase, and GPx were normalized by FI fruits in isoprenaline-induced rats. Besides, expression of inflammatory mediators i.e., IL-1, IL-6, TNF-α, TGF-β, iNOS, and NF-κB were also suppressed by FI fruits. The outcome of FI fruits treatment was noted as promising and comparable to the standard atenolol treatment. The enhanced biological activity shown by FI fruits may be due to its abundant polyphenolic compounds as determined by HPLC analysis. In conclusion, FI fruits may protect cardiac tissue in isoprenaline-administered rats by suppressing the oxidative stress and proinflammatory mediators and enhancing the antioxidant enzyme functions.

The study aimed to investigate the nephroprotective and cardioprotective effects of ethanol extract of litchi leaf (LI) in two-kidney-one-clip (2K1C) rat model. HPLC analysis revealed the presence of several polyphenolic antioxidants in LI. Correspondingly, LI at 50–200 mg/kg reduced the level of oxidative stress markers (MDA, APOP, NO) and improved level of endogenous antioxidant enzymes (CAT, SOD) in 2K1C rats. Besides, LI caused significant improvements in kidney and heart functions in 2K1C rats by reducing the plasma level of uric acid and creatinine as well as CK-MB. Consistent with the biochemical findings, histopathological data further confirmed that LI is effective in decreasing heart and kidney injuries, oxidative stress and inflammation which ensued in 2K1C rats. Collectively, the outcomes suggest that the LI enriched in polyphenolic antioxidants may provide the protection against excessive oxidative stress, inflammation and tissue injury, thereby improving the kidney and heart function in 2K1C rats.

• HPLC analysis revealed the presence of potent polyphenolics in ramontchi. • Polyphenolics in ramontchi impede cardiac damages in Long-Evans rats. • Ramontchi normalized expressions of antioxidant genes i.e. , Nrf-2, HO-1, HO-2, GPx, SOD and CAT. • Ramontchi suppressed the expressions of inflammatory mediators i.e. , IL-1, IL-6, TNF-α, TGF-β1, iNOS and NF-κB. • Ramontchi diminished the level of oxidative stress in isoprenaline-induced rats. This investigation was aimed to explore the cardioprotective effect of Ramontchi fruits (Flacourtia indica ; FI) in isoprenaline-administered Long-Evans rats. Administration of isoprenaline increased the total heart wet weight, MDA, NO, and APOP as well as ALT, AST, and CK-MB levels, which were normalized by FI fruits treatment. Moreover, expressions of antioxidant genes i.e. , Nrf-2, HO-1, HO-2, SOD, catalase, and GPx were normalized by FI fruits in isoprenaline-induced rats. Besides, expression of inflammatory mediators i.e. , IL-1, IL-6, TNF-α, TGF-β, iNOS, and NF-κB were also suppressed by FI fruits. The outcome of FI fruits treatment was noted as promising and comparable to the standard atenolol treatment. The enhanced biological activity shown by FI fruits may be due to its abundant polyphenolic compounds as determined by HPLC analysis. In conclusion, FI fruits may protect cardiac tissue in isoprenaline-administered rats by suppressing the oxidative stress and proinflammatory mediators and enhancing the antioxidant enzyme functions. [ABSTRACT FROM AUTHOR]

• HPLC analysis of litchi leaf revealed the presence of polyphenolic antioxidants. • Litchi leaf markedly reduced the level of several oxidative stress in 2K1C rats. • Litchi leaf improved the level of endogenous antioxidant enzymes in 2K1C rats. • It improved the kidney and heart function reducing uric acid, creatinine and CK-MB. The study aimed to investigate the nephroprotective and cardioprotective effects of ethanol extract of litchi leaf (LI) in two-kidney-one-clip (2K1C) rat model. HPLC analysis revealed the presence of several polyphenolic antioxidants in LI. Correspondingly, LI at 50–200 mg/kg reduced the level of oxidative stress markers (MDA, APOP, NO) and improved level of endogenous antioxidant enzymes (CAT, SOD) in 2K1C rats. Besides, LI caused significant improvements in kidney and heart functions in 2K1C rats by reducing the plasma level of uric acid and creatinine as well as CK-MB. Consistent with the biochemical findings, histopathological data further confirmed that LI is effective in decreasing heart and kidney injuries, oxidative stress and inflammation which ensued in 2K1C rats. Collectively, the outcomes suggest that the LI enriched in polyphenolic antioxidants may provide the protection against excessive oxidative stress, inflammation and tissue injury, thereby improving the kidney and heart function in 2K1C rats. [ABSTRACT FROM AUTHOR]