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Carboxylated chitosan(C-COS) is prepared by selective oxidation of chitosan (COS) using lac case/2, 2, 6, 6-tetramethylpiperidine-l-oxyl radical (TEMPO) system to change its hydroxyl group on C6 to carboxyl group. Free radical-induced in vitro lipid oxidation experiments are performed using lecithin and linoleic acid as the experimental subject. After the addition of COS and C-COS, the inhibitory effect of COS and C-COS on lipid peroxidation is investigated by comparing the production and peroxide value of conjugated diene and malondialdehyde, and the structural changes of fatty acids are compared according to FT-TR and 1 H NMR spectra. Results show that the maximum anti lipid oxidation inhibition rate of C-COS is 87%, which is higher than that of COS, and the maximum increase is 55%. The amino and carboxyl groups on C-COS act together to effectively capture free radicals from providing electrons and chelating metal ions, so as to avoid lipid peroxidation. [ABSTRACT FROM AUTHOR]

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