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Your search keyword '"Yoshi Nagahata"' showing total 2 results
Start Over Author "Yoshi Nagahata" Journal journal of gastroenterology
2 results on '"Yoshi Nagahata"'

1. Impaired response of gastric vessels to prostaglandin E2 in rats with persistent obstructive jaundice

Author

Yoshi Nagahata, Hirohiko Onoyama, Masahumi Yano, Hitoshi Moritomo, Masahiro Yamamoto, Norihisa Numata, Naoto Kawakita, and Yasutomo Azumi

Subjects
Male, medicine.medical_specialty, Prostaglandin, In Vitro Techniques, Gastroenterology, Dinoprostone, chemistry.chemical_compound, Internal medicine, medicine, Gastric mucosa, Animals, Prostaglandin E2, Rats, Wistar, Cholestasis, Dose-Response Relationship, Drug, Bile duct, business.industry, Stomach, digestive, oral, and skin physiology, Hemodynamics, Bilirubin, Blood flow, Hepatology, Rats, medicine.anatomical_structure, chemistry, Gastric Mucosa, Regional Blood Flow, business, Perfusion, medicine.drug
Abstract

We investigated the response of gastric vessels to prostaglandin (PG) E2 after intra-duodenal release of bile in rats with obstructive jaundice. The animals were divided into four groups according to duration of bile duct obstruction (BDO): control and 1 week (W), 2W, and 3W groups. Prolonged BDO decreased gastric mucosal blood flow (BF) significantly. The BF recovered after the release of BDO in the 1W and 2W groups, but not in the 3W group. BDO decreased PGE2 content in gastric mucosa in the 1W, 2W, and 3W groups. PGE2 decreased vascular perfusion pressure of the isolated stomach in the control and 2W groups, but not in the 3W group. The response of gastric vessels to PGE2 was poor in the 3W group compared with the control and 2W groups. Decreased PGE2 in the gastric mucosa and decreased response of gastric vessels to PGE2 may affect gastric blood flow in obstructive jaundice.

Published
1997

2. Immunohistochemical study of dopamine in rat gastric mucosa with acute gastric ulcer

Author

Naoto Kawakita, Yoshi Nagahata, and Yoichi Saitoh

Subjects
Male, Restraint, Physical, medicine.medical_specialty, Pathology, Dopamine, Regulation of gastric function, Gastroenterology, Rats, Sprague-Dawley, Stress, Physiological, Internal medicine, Gastric glands, Immersion, Gastric mucosa, Medicine, Animals, Stomach Ulcer, Enterochromaffin-like cell, Antrum, business.industry, digestive, oral, and skin physiology, Immunohistochemistry, digestive system diseases, Epithelium, Rats, Gastric chief cell, Foveolar cell, Microscopy, Electron, medicine.anatomical_structure, Gastric Mucosa, Acute Disease, business
Abstract

Recent studies have shown the presence of dopamine (DA) in gastric and duodenal mucosa, and changes in gastric mucosal DA content have been observed in patient with acute ulcers. Immunohistochemical demonstration of the distribution of DA in gastric mucosa under stress was studied by light and electron microscopy. In the control group, DA was present in the gastric gland proper in the gastric corpus and antrum on light microscopy, and on the surface of mucous granules in chief cells, mucous neck cells, and surface epithelium on electron microscopy. In the stress group, DA in gastric mucosa was almost undetectable on light and electron microscopy. Further, in this group serum DA concentration was significantly higher in the portal vein than in the abdominal aorta. Endogenous DA in gastric mucosal cells may affect gastric mucosa differently from exogenous DA, and stress may release endogenous intracellular DA into extracellular spaces.

Published
1994

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