Search

Your search keyword '"Selma J. Lekkerkerker"' showing total 2 results
Start Over Author "Selma J. Lekkerkerker" Journal journal of gastroenterology and hepatology
2 results on '"Selma J. Lekkerkerker"'

1. Clinical outcomes and prevalence of cancer in patients with possible groove pancreatitis

Author

Thomas M. van Gulik, Joanne Verheij, Selma J. Lekkerkerker, Paul Fockens, Erik A.J. Rauws, Olivier R. Busch, Marc G. Besselink, Marja A. Boermeester, Chung Y. Nio, Yama Issa, and Jeanin E. van Hooft

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Cancer, Retrospective cohort study, Jaundice, medicine.disease, Malignancy, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Pancreatic cancer, medicine, Pancreatitis, 030211 gastroenterology & hepatology, Pancreatitis, chronic, medicine.symptom, Differential diagnosis, business
Abstract

Background and Aim: Data on non-surgical treatment of groove pancreatitis (GP) and the risk of cancer are lacking. We aimed to determine the prevalence and predictors of cancer in patients in whom the diagnosis GP was considered, and to evaluate symptom improvement after treatment. Study: Patients referred with possible GP (2001-2014) were retrospectively included. An experienced radiologist reassessed imaging. GP patients received questionnaires evaluating their symptoms. Results: From the 38 possible GP patients, 10 had cancer (26%) and 28 GP (74%). Compared with cancer patients, GP patients more frequently had cysts (2/10 vs. 18/28, P = 0.03), less often jaundice (6/10 vs 3/27, P

Published
2016
Full Text
View/download PDF

2. Clinical outcomes and prevalence of cancer in patients with possible groove pancreatitis

Author

Selma J, Lekkerkerker, Chung Y, Nio, Yama, Issa, Paul, Fockens, Joanne, Verheij, Olivier R, Busch, Thomas M, van Gulik, Erik A, Rauws, Marja A, Boermeester, Jeanin E, van Hooft, and Marc G, Besselink

Subjects
Diagnosis, Differential, Male, Pancreatic Neoplasms, Treatment Outcome, Pancreatitis, Chronic, Patient Selection, Humans, Female, Middle Aged, Tomography, X-Ray Computed, Follow-Up Studies, Retrospective Studies
Abstract

Data on non-surgical treatment of groove pancreatitis (GP) and the risk of cancer are lacking. We aimed to determine the prevalence and predictors of cancer in patients in whom the diagnosis GP was considered, and to evaluate symptom improvement after treatment.Patients referred with possible GP (2001-2014) were retrospectively included. An experienced radiologist reassessed imaging. GP patients received questionnaires evaluating their symptoms.From the 38 possible GP patients, 10 had cancer (26%) and 28 GP (74%). Compared with cancer patients, GP patients more frequently had cysts (2/10 vs. 18/28, P = 0.03), less often jaundice (6/10 vs 3/27, P 0.01), an abrupt caliber change of the CBD (5/10 vs. 2/28, P 0.01) or suspicious cytology (5/9 vs 2/20, P = 0.02). Of the 28 GP patients, 14 patients were treated conservatively of whom 12 reported symptom improvement after a median follow-up of 45 months (range 7-127 months). All 6 patients treated endoscopically and 7/8 patients treated surgically reported symptom improvement. Surgery, performed because of treatment failure (3/8) or inability to exclude malignancy (5/8), caused mortality in 1/8 patients.Suspicion of pancreatic cancer should be high in patients presenting with possible GP. Conservative, endoscopic and surgical treatment can all lead to symptom improvement, suggesting a 'step-up approach' to GP once cancer is excluded.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results