1. Adherence to colonoscopy in cascade screening of colorectal cancer: A systematic review and meta‐analysis
- Author
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Weimiao Wu, Tao Ying, Yangming Gong, Dandan Mao, Kai Gu, Martin C.S. Wong, Junjie Huang, Pingping Bao, Hung N. Luu, Mellissa Withers, Songsong Tan, Sikun Chen, Jiongxing Fu, Chen Yang, Wanghong Xu, and Yihui Yang
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Hepatology ,business.industry ,Colorectal cancer ,Incidence (epidemiology) ,Gastroenterology ,Colonoscopy ,Cochrane Library ,medicine.disease ,Confidence interval ,Meta-analysis ,Internal medicine ,Occult Blood ,medicine ,Humans ,Mass Screening ,Observational study ,Risk assessment ,business ,Colorectal Neoplasms ,Sigmoidoscopy ,Early Detection of Cancer - Abstract
Background: Adherence-to-colonoscopy in cascade screening of colorectal cancer (CRC) is crucial to the effectiveness of screening, but it has not been systematically evaluated. We aimed to evaluate the colonoscopy adherence among average-risk populations globally. Methods: We searched Pubmed, Embase, Web of Science, and Cochrane Library for observational and experimental studies published in English up to December 31, 2018 and reporting the colonoscopy adherence following positive initial screening. We calculated pooled adherence with its 95% confidence intervals (CIs) using a random-effects meta-analysis. Subgroup and mixed-effects meta-regression analysis were performed to evaluate heterogeneous factors for adherence. Findings: Of 9,772 articles identified, 191 (313 studies) were included in the systematic review. The pooled adherence-to-colonoscopy was 81·6% (95% CI: 79·6-83·4), with the estimates varying substantially by continents, CRC incidence, GDP per capita, recruitment method, screening round and type of initial test. Type of initial test was the most modifiable heterogeneous factor for adherence across studies (Q=53·00, P
- Published
- 2022
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