1. Immunohistochemical Expression of ROR2 in Gastrointestinal Stromal Tumor.
- Author
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Abdou AG, Kandil M, Abd El Wahed M, Elakabawy Z, Loay I, and El-Rebey HS
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Prognosis, Adult, Aged, 80 and over, Gastrointestinal Stromal Tumors metabolism, Gastrointestinal Stromal Tumors pathology, Gastrointestinal Stromal Tumors diagnosis, Receptor Tyrosine Kinase-like Orphan Receptors metabolism, Immunohistochemistry, Biomarkers, Tumor metabolism, Biomarkers, Tumor analysis, Gastrointestinal Neoplasms metabolism, Gastrointestinal Neoplasms pathology
- Abstract
Background: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors affecting the digestive tract, comprising approximately 0.1-3% of all gastrointestinal cancers. ROR2, a member of the receptor tyrosine kinase orphan receptor subfamily, functions as a signaling receptor for Wnt ligands. This study aims to assess the prognostic significance of ROR2 expression in GIST., Methods: A total of 56 paraffin-embedded blocks of GIST cases originating from different parts of the gastrointestinal tract (GIT) were included in this study. Immunohistochemistry was performed to detect ROR2 expression., Results: ROR2 expression was observed in 71.4% of GIST cases, and strong intensity of ROR2 staining was significantly associated with prolonged overall survival of GIST patients (p = 0.048). Furthermore, ROR2 positivity and the percentage of immunostaining showed an inverse correlation with tumor progression., Conclusions: GIST cases displaying ROR2 positivity exhibit a reduced likelihood of disease progression and demonstrate favorable prognostic characteristics., Competing Interests: Declarations. Competing Interests: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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