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Your search keyword '"Shaifali"' showing total 8 results
Start Over Author "Shaifali" Journal journal of gastrointestinal cancer
8 results on '"Shaifali"'

1. Practice Patterns and Survival in Patients with Resected Pancreatic Ductal Adenocarcinomas (PDAC) — Results from the Multicentre Indian Pancreatic & Periampullary Adenocarcinoma Project (MIPPAP) Study

Author

Chaudhari, Vikram, Ramaswamy, Anant, Srinivas, Sujay, Agarwal, Ajit, Seshadri, Ramakrishnan Ayloor, Talwar, Vineet, Bhargava, Prabhat, Goel, Shaifali, Kayal, Smita, Rebala, Pradeep, Prajapati, Bharat, Parikh, Devendra, Kothari, Jagdish, Ch, Ramesh M., Kadamapuzha, Jacob Mathew, Kapoor, Deeksha, Chaudhary, Adarsh, Goel, Varun, Singh, Shivendra, Ghosh, Joydeep, Lavingia, Viraj, Gupta, Amit, Sekar, Anbarasan, Misra, Sanjeev, Vishnoi, Jeewan Ram, Soni, Subhash, Varshney, Vaibhav Kumar, Bairwa, Sandeep, Bhandare, Manish, Shrikhande, Shailesh V., and Ostwal, Vikas

Published
2023
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5. Use of 18F Fluorodeoxyglucose Positron Emission Tomography Computed Tomography in Assessing Response to Neoadjuvant Chemoradiation and Its Impact on Survival in Esophageal Squamous Cell Carcinoma

Author

Shaifali Goel, Nikhil Gupta, Abhishek Aggarwal, Shivendra Singh, Vineet Talwar, Manoj Gupta, Sayed Assif Iqbal, and Garima Durga

Subjects
PET-CT, medicine.medical_specialty, Receiver operating characteristic, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Gastroenterology, Computed tomography, Standardized uptake value, Fluorodeoxyglucose positron emission tomography, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Statistical significance, Medicine, 030211 gastroenterology & hepatology, Radiology, business, Pathological
Abstract

To determine the accuracy of 18F-Fluorodeoxyglucose positron emission tomography computed tomography (FDG-PET CT) in predicting response to neoadjuvant chemoradiation (NACRT) in esophageal squamous cell cancer (SCC) and impact of such response on survival. Retrospective analysis of patients with esophageal SCC (cT2-4N0-N+M0) who underwent PET CT before and 6 weeks after NACRT followed by surgery was carried out in this study. Metabolic response was assessed by change in standardized uptake value (ΔSUVmax) after NACRT and the pathological response was graded. A receiver operating characteristic curve (ROC) was used to identify the optimal cut off value of SUVmax to predict histopathological response. The impact of metabolic response and pathological response on survival was determined. Of the 73 patients analyzed, 27 had complete metabolic response, while 24 had pathological complete response (PCR). However, only 14 of the 27 complete metabolic responders actually had PCR. At 67% ΔSUVmax, the optimum balance between sensitivity (70.83%) and specificity (69.23%) was achieved and the correlation between metabolic response and pathological complete response achieved statistical significance (p = 0.0009). However, ΔSUVmax of 67% was found to have no significant association with survival (p = 0.51). PCR was the only significant determinant of improved survival (p = 0.04). PCR which is a significant determinant of survival is not ideally predicted by ΔSUVmax on PET CT.

Published
2020

6. Use of

Author

Sayed Assif, Iqbal, Shaifali, Goel, Abhishek, Aggarwal, Nikhil, Gupta, Manoj, Gupta, Garima, Durga, Vineet, Talwar, and Shivendra, Singh

Subjects
Adult, Male, Esophageal Neoplasms, India, Chemoradiotherapy, Middle Aged, Polymerase Chain Reaction, Sensitivity and Specificity, Neoadjuvant Therapy, Survival Rate, ROC Curve, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Humans, Female, Esophageal Squamous Cell Carcinoma, Radiopharmaceuticals, Aged, Retrospective Studies
Abstract

To determine the accuracy ofRetrospective analysis of patients with esophageal SCC (cT2-4N0-N+M0) who underwent PET CT before and 6 weeks after NACRT followed by surgery was carried out in this study. Metabolic response was assessed by change in standardized uptake value (ΔSUVOf the 73 patients analyzed, 27 had complete metabolic response, while 24 had pathological complete response (PCR). However, only 14 of the 27 complete metabolic responders actually had PCR. At 67% ΔSUVPCR which is a significant determinant of survival is not ideally predicted by ΔSUV

Published
2020

8. Use of 18F Fluorodeoxyglucose Positron Emission Tomography Computed Tomography in Assessing Response to Neoadjuvant Chemoradiation and Its Impact on Survival in Esophageal Squamous Cell Carcinoma.

Author

Iqbal, Sayed Assif, Goel, Shaifali, Aggarwal, Abhishek, Gupta, Nikhil, Gupta, Manoj, Durga, Garima, Talwar, Vineet, and Singh, Shivendra

Abstract

Background: To determine the accuracy of 18F-Fluorodeoxyglucose positron emission tomography computed tomography (FDG-PET CT) in predicting response to neoadjuvant chemoradiation (NACRT) in esophageal squamous cell cancer (SCC) and impact of such response on survival. Methods: Retrospective analysis of patients with esophageal SCC (cT2-4N0-N+M0) who underwent PET CT before and 6 weeks after NACRT followed by surgery was carried out in this study. Metabolic response was assessed by change in standardized uptake value (ΔSUVmax) after NACRT and the pathological response was graded. A receiver operating characteristic curve (ROC) was used to identify the optimal cut off value of SUVmax to predict histopathological response. The impact of metabolic response and pathological response on survival was determined. Results: Of the 73 patients analyzed, 27 had complete metabolic response, while 24 had pathological complete response (PCR). However, only 14 of the 27 complete metabolic responders actually had PCR. At 67% ΔSUVmax, the optimum balance between sensitivity (70.83%) and specificity (69.23%) was achieved and the correlation between metabolic response and pathological complete response achieved statistical significance (p = 0.0009). However, ΔSUVmax of 67% was found to have no significant association with survival (p = 0.51). PCR was the only significant determinant of improved survival (p = 0.04). Conclusion: PCR which is a significant determinant of survival is not ideally predicted by ΔSUVmax on PET CT. [ABSTRACT FROM AUTHOR]

Published
2021
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