1. Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans
- Author
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Bok Ghee Han, Bok Soo Lee, Sang Hak Lee, Yangsoo Jang, Min Young Park, Sanghoon Moon, Yun Kyoung Kim, Jeong Euy Park, and Ji-Young Lee
- Subjects
0301 basic medicine ,Adult ,Male ,Genotype ,Myocardial Infarction ,Genome-wide association study ,030204 cardiovascular system & hematology ,Biology ,Genome ,Polymorphism, Single Nucleotide ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Ribonucleases ,Asian People ,Risk Factors ,Exome Sequencing ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetic variability ,Myocardial infarction ,Gene ,Exome sequencing ,Genetic association ,Adaptor Proteins, Signal Transducing ,Glycoproteins ,Middle Aged ,medicine.disease ,030104 developmental biology ,Glucosyltransferases ,Female ,Carrier Proteins ,Genome-Wide Association Study - Abstract
Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.
- Published
- 2018