1. Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model
- Author
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Sinan Mermer, Tuncer Turhan, Elif Bolat, Sohret Aydemir, Tansu Yamazhan, Husnu Pullukcu, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy, and Oguz Resat Sipahi
- Subjects
Nosocomial meningitis ,Methicillin-resistant staphylococci ,Central nervous system infection ,Glycopeptides ,Animal model ,Pharmacokinetics ,Microbiology ,QR1-502 - Abstract
Objectives: The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. Methods: The antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24 h and 73 h after the first antibiotic dose. Furthermore, in vitro time–kill data were investigated at 0, 2, 4, 6, 8, 12 and 24 h in sterile human serum. Results: The difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24 h and 73 h after the first antibiotic dose (P
- Published
- 2020
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