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Start Over Author "Jin-Bao Liu" Journal journal of hainan medical university
2 results on '"Jin-Bao Liu"'

1. Study on novel coronavirus pneumonia (COVID-19) mechanism by Huashi Baidu Formula based on network pharmacology

Author

Yuan Liu, Jin-Bao Liu, and Wei Peng

Subjects
huashi baidu formula, sars-cov-2, covid-19, lcsh:R, chinese medicine, network pharmacology, lcsh:Medicine
Abstract

Objective: To explore novel coronavirus pneumonia (COVID-19) by the method of network pharmacology. Methods: The compounds contained in the Huashi Baidu Formula were searched by TCMSP database, the active components and their action targets were screened, and the proteins were standardized by Uniprot database, and the drug-active ingredienttarget network was constructed by Cytoscape3.7.2 software. The targets related to COVID- 19 were screened by GeneCards database. STRING database and DAVID database were used to construct and analyze PPI network, GO analysis and KEGG enrichment analysis(P < 0.05). Results: The "drug-active ingredient-target" network of Huashi Baidu Formula consists of 176 components and 149targets, including AR, ESR1, PTGS2, PPARG, NOS2 and so on. 251 targets related to COVID-19. GO functional enrichment analysis showed that there were 179 biological processes, mainly related to inflammation, regulation of apoptosis and immune response, and 82 KEGG related signaling pathways were obtained, including HIF-1, TNF, small cell lung cancer, non-small cell lung cancer, tuberculosis, PI3K-Akt, NF- κ B, MAPK and so on. Conclusion: Huashi Baidu Formula may regulate the immune and inflammatory response of the body by acting on AR, ESR1, PTGS2, PPARG, NOS2 and other targets, which is the result of multi-component, multi-target and multi-channel interaction.

Published
2020

2. Molecular mechanism of Duhuojisheng Decoction in the treatment of knee osteoarthritis based on the network pharmacology.

Author

Yuan Liu, Bo Xu, Jin-Bao Liu, Jing-Zhou Zhang, and Gang Li

Subjects
OSTEOARTHRITIS treatment, PHARMACOLOGY, RHEUMATOID arthritis, CELL proliferation, APOPTOSIS
Abstract

Objective: To explore the molecular mechanism of Duhuojisheng Decoction in the treatment of knee osteoarthritis (KOA). Methods: through tcmsp database and Batman TCM database, the compounds in Duhuo Jisheng decoction, such as Duhuo, sangparasitic, eucommia, Achyranthes bidentata, asarum, Gentiana macrophylla, Poria cocos, cinnamon, Fangfeng, chuanxiong, ginseng, liquorice, angelica, white peony and raw rehmannia, were searched, and their active components and targets were screened The target of KOA was acquired by database; the drug compound target network was constructed by using the software of cycloscape 3.7.2, and PPI network was constructed and analyzed by using string database; go analysis and KEGG enrichment analysis were conducted by using David database (P < 0.05). Results: after screening, 217 components and 155 targets were obtained for the treatment of KOA; 5653 targets were related to koa; 79 proteins were related to PPI core network, including INS, IL6, TNF and VEGFA; 301 go biological processes and 114 related signal pathways were obtained, including rheumatoid arthritis, osteoclast differentiation, MAPK signal pathway, HIF-1 signal pathway and PI3K Akt signal pathway, TNF signal pathway, etc. Conclusion: Duhuo parasitic decoction may regulate cell proliferation, apoptosis and inflammatory response to treat koa, which is the result of multi-component, multi-target and multi-channel interaction, providing theoretical support for Duhuo parasitic Decoction to treat KOA. [ABSTRACT FROM AUTHOR]

Published
2020

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