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Infection caused by the new Coronavirus (SARS-COV-2) causes a variable clinical feature. Due to its high transmissibility, Covid-19 was declared a pandemic. In view of this, in Brazil, the Ministry of Education (MEC) published an ordinance that temporarily suspended face-toface activities at Higher Education Institutions (HEIs). Despite this and other measures, the number of cases and deaths in Brazil has, so far, has increased exponentially, a fact that impacts the health and educational authorities, due to the exceptionality imposed on the development of teaching activities. Because of such context, the present study aimed to measure the frequency of the Flu Syndrome in medical students from Mato Grosso do Sul during the Covid-19 pandemic period, in order to propose resolutions for conducting academic activities. A descriptive, observational and cross-sectional study carried out among students enrolled in medicine school courses in the state of Mato Grosso do Sul. The data were obtained through a semi-structured, online questionnaire and based on the Google Forms platform. Descriptive results were prepared automatically, from the platform itself. Result: 371 responses were computed. Approximately 50% had flu-like symptoms, the most common of which were runny nose, nasal obstruction and cough. Among the diagnoses reported, the most described one was rhinosinusitis, with 7 participants presenting Covid-19. It was possible to measure the condition of flu-like syndrome among medicine school students in this state, seeking to provide support and possible basis for decision-making by the medical courses coordinators in Mato Grosso do Sul regarding the referral of academic activities. [ABSTRACT FROM AUTHOR]