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Your search keyword '"Zhao, You"' showing total 2 results
Start Over Author "Zhao, You" Topic prognosis Journal journal of hepatology
2 results on '"Zhao, You"'

1. Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma

Author

Peng-Yuan Zhuang, Wei Zhang, Zhao-You Tang, Qing-Hai Ye, Ning Ren, Bo-Heng Zhang, Jia Fan, Hui-Chuan Sun, Lu Wang, Lun-Xiu Qin, and Xiao-Dong Zhu

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Hepatitis B virus, Carcinoma, Hepatocellular, Gastroenterology, Sensitivity and Specificity, Macronodular cirrhosis, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Carcinoma, Humans, Hepatitis B e Antigens, Prospective Studies, Risk factor, Survival rate, Hepatology, business.industry, Hazard ratio, Liver Neoplasms, Hepatitis B, Middle Aged, Viral Load, medicine.disease, Prognosis, digestive system diseases, Surgery, Survival Rate, Biliary Tract Surgical Procedures, Treatment Outcome, HBeAg, Hepatocellular carcinoma, Female, Neoplasm Recurrence, Local, business, Biomarkers
Abstract

Background/Aims To study the impact of hepatitis B e antigen on tumor recurrence and patients' survival after curative resection of hepatocellular carcinoma. Methods Two hundred and three patients with small hepatocellular carcinomas (⩽3cm) who had undergone curative resection were divided into HBeAg-positive group and HBeAg-negative group. Clinicopathological factors and postoperative outcomes were compared between groups, and risk factors for survival and recurrence were studied. Results The median follow-up time was 32.9months. Patients with negative HBeAg had higher 5-year overall survival rates (76% vs 53.9%, hazards ratio (HR): 2.363, 95% CI: 1.335–4.181, p =0.002) and 5-year disease-free survival rates (52.9% vs 37.4%, HR: 1.603, 95% CI: 1.00–2.561, p =0.046).There was no significant difference in operative morbidity and tumor factors between the two groups, but younger age, higher serum alanine aminotransferase levels, and more macronodular cirrhosis were found in the HBeAg-positive group. Multivariate analysis revealed that age >50years, HBeAg positivity and macronodular cirrhosis were independent factors for overall survival, and HBeAg positivity and multiple tumor nodules were independent factors for disease-free survival. Positive serum HBeAg was associated with a higher risk of early recurrence (within 1year). Conclusions HBeAg is associated with a higher risk of early recurrence and poorer survival in patients after curative resection of small HCC.

Published
2007

2. Let-7g targets collagen type I α2 and inhibits cell migration in hepatocellular carcinoma

Author

Ji, Junfang, Zhao, Lei, Budhu, Anuradha, Forgues, Marshonna, Jia, Hu-Liang, Qin, Lun-Xiu, Ye, Qing-Hai, Yu, Jinming, Shi, Xuetao, Tang, Zhao-You, and Wang, Xin Wei

Subjects
*LIVER cancer, *COLLAGEN, *CELL migration, *METASTASIS, *NON-coding RNA, *GENE expression, *DIAGNOSTIC use of polymerase chain reaction, *GROWTH factors
Abstract

Background & Aims: Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis. Methods: Quantitative real-time polymerase chain reaction was used to determine the level of mature let-7g transcript in HCC clinical specimens and its correlation with patient survival. Ectopic expression of let-7g was carried out in HCC cell lines to assess its influence on cell growth, migration, and invasion. Results: We confirmed that the level of let-7g was significantly lower in metastatic HCCs compared to metastasis-free HCCs. Moreover, low let-7g expression in a tumour was predictive of poor survival in HCC patients. Functional studies indicated that ectopic expression of let-7g significantly inhibits HCC cell migration and cell growth. In-silico analysis revealed members of soluble collagens as potential targets of let-7g. Consistently, the levels of type I collagen α2 (COL1A2) and let-7g were inversely correlated in HCC clinical specimens. COL1A2 was experimentally validated as a direct target of let-7g. Moreover, addition of COL1A2 counteracted the inhibitory effect of let-7g on cell migration. Conclusions: These results suggest that let-7g may suppress HCC metastasis partially through targeting COL1A2. [Copyright &y& Elsevier]

Published
2010
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