1. Impact of viral eradication on mortality related to hepatitis C: A modeling approach in France
- Author
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Sébastien Dharancy, Pierre Deltenre, Alexandre Louvet, J. Boitard, Jean Henrion, Yazdan Yazdanpanah, Antoine Hollebecque, Sylvie Deuffic-Burban, Valérie Canva, and Philippe Mathurin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Alcohol Drinking ,Population ,Antiviral Agents ,Sensitivity and Specificity ,Young Adult ,Liver disease ,Internal medicine ,Epidemiology ,Humans ,Mass Screening ,Medicine ,Computer Simulation ,education ,Aged ,education.field_of_study ,Models, Statistical ,Hepatology ,business.industry ,Incidence ,Antiviral therapy ,Hepatitis C ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Markov Chains ,Surgery ,Standardized mortality ratio ,Hepatocellular carcinoma ,Female ,France ,Viral disease ,business - Abstract
Background/Aims In France, two recent studies enabled modeling of the impact of viral eradication on HCV mortality. Methods The French HCV population was simulated from infection to death using a computer-based model. We took into account the impact of alcohol, present screening and antiviral therapy to predict 2006–2025 HCV mortality and to assess the impact of viral eradication. Results In 2006, the model estimated that among HCV-RNA+, 55% were F0–F1, 18% F2, 22% F3–F4 and 6% had liver complications. The mortality ratio was 11-fold higher in alcoholic patients 40–65 years old. Current therapy will save 14,400 (95% CI, 13,900–15,000) lives compared to absence of therapy. Sensitivity analyses did not change the main results. Contrary to guidelines, if patients F F ⩾2, 700 (95% CI, 700–750) lives would be saved. If screening were to reach 75% in 2010, 4 years earlier than model expectation, 950 (95% CI, 900–1000) lives would be saved. If a new molecule improving eradication for genotype 1/4 by 40% were to become available in 2010, 1500 (95% CI, 1400–1600) lives would be saved. Conclusions Current therapy is reducing HCV mortality. Therapeutic guidelines must take into account their impact on HCV mortality.
- Published
- 2008