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Your search keyword '"Chung, Y."' showing total 35 results
Start Over Author "Chung, Y." Journal journal of hepatology
35 results on '"Chung, Y."'

2. Close association of arrest-defective protein 1 (ARD1) overexpression with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma

Author

Lee, D., primary, Kang, H.J., additional, Chung, Y.-H., additional, Choi, G.H., additional, Seo, J.H., additional, Park, J.-H., additional, Lee, H.S., additional, Choi, J., additional, Jang, M.-K., additional, Ryu, S.H., additional, Lee, Y.J., additional, Yu, E., additional, and Kim, K.-W., additional

Published
2017
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5. The prognostic value of hepatic artery and portal vein involvement in patients with perihilar cholangiocarcinoma

Author

Jaynee Vugts, W.G. Polak, Marcia P. Gaspersz, François E. J. A. Willemssen, J. van Vugt, Chung Y. Nio, Bas Groot Koerkamp, J. N. M. Ijzermans, J. de Jonge, R. Coelen, T.M. van Gulik, and Tim A. Labeur

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Hepatology, business.industry, medicine, Portal vein, In patient, Radiology, Perihilar Cholangiocarcinoma, business, Value (mathematics), Artery
Published
2017
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8. O128 SURGICAL RESECTION VERSUS RADIOFREQUENCY ABLATION IN THE TREATMENT OF PATIENTS WITH SOLITARY HEPATOCELLULAR CARCINOMA WITHOUT PORTAL HYPERTENSION: A 10-YEAR OUTCOME STUDY

Author

Kim, G.-A., primary, Shim, J.H., additional, Kim, S.Y., additional, Won, H.J., additional, Shin, Y.M., additional, Kim, P.N., additional, Lee, Y.-J., additional, Lee, S.-G., additional, Lee, D., additional, Kim, K.M., additional, Lim, Y.-S., additional, Lee, H.C., additional, Chung, Y.-H., additional, and Suh, D.J., additional

Published
2014
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10. 261 VASCULAR ENDOTHELIAL GROWTH FACTOR AS A PREDICTOR OF RESPONSE TO THE COMBINED THERAPY WITH SORAFENIB AND TRANSARTERIAL CHEMOEMBOLIZATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

Author

Lee, D., primary, Chung, Y.-H., additional, Kim, J.A., additional, Lee, J.-H., additional, Shin, E.-S., additional, Shim, J.-H., additional, Lee, H.C., additional, Yoon, J.H., additional, Kim, B.I., additional, Bae, S.H., additional, Koh, K.C., additional, Ryu, S.H., additional, and Park, N.-H., additional

Published
2013
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12. 1019 GENETIC POLYMORPHISM ASSOCIATED WITH POOR LONG-TERM OUTCOME OF HEPATOCELLULAR CARCINOMA PATIENTS FOLLOWING THE COMBINED THERAPY WITH TRANSARTERIAL CHEMOEMBOLIZATION AND SORAFENIB

Author

Lee, J.-H., primary, Chung, Y.-H., additional, Kim, J.A., additional, Shin, E.-S., additional, Lee, D., additional, Shim, J.H., additional, Lee, H.C., additional, Yoon, J.H., additional, Kim, B.I., additional, Bae, S.H., additional, Koh, K.C., additional, Kim, G., additional, and Park, N.-H., additional

Published
2012
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18. 989 PREDISPOSING FACTORS FOR POOR CLINICAL OUTCOME OF HEPATITIS B VIRUS ASSOCIATED HEPATOCELLULAR CARCINOMA FOLLOWING CURATIVE RESECTION: FOCUSED ON THE GENOMIC CHANGES IN HEPATITIS B VIRUS

Author

Mathews, P., primary, Chung, Y.-H., additional, Kim, J.A., additional, Lee, D., additional, Lee, J.-H., additional, Lyu, H., additional, Jin, Y.-J., additional, Park, W., additional, Jaffee, E., additional, Zheng, L., additional, Yu, E., additional, and Lee, Y.J., additional

Published
2011
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19. 639 SINGLE NUCLEOTIDE POLYMORPHISM ASSOCIATED WITH TUMOR RESPONSE TO THE COMBINED THERAPY WITH TRANSARTERIAL CHEMOEMBOLIZATION AND SORAFENIB IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

Author

Lee, J.-H., primary, Chung, Y.-H., additional, Kim, J.A., additional, Shin, E.-S., additional, Lee, D., additional, Shim, J.H., additional, Lee, H.C., additional, Yoon, J.H., additional, Kim, B.I., additional, Bae, S.H., additional, Koh, K.C., additional, Kim, G., additional, and Park, N.-H., additional

Published
2011
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25. 691 EFFESTS OF RESPONSE TO INTERFERON THERAPY ON THE PROGRESSION TO DECOMPENSATION IN PATIENTS WITH CHRONIC HEPATITIC B

Author

Jang, M.K., primary, Chung, Y.-H., additional, Yu, E., additional, Shin, H.D., additional, Lee, S.H., additional, Lee, D., additional, Kim, S.E., additional, Lee, Y.-S., additional, Kim, S.H., additional, Yang, S.H., additional, Kim, K.M., additional, Lim, Y.S., additional, Lee, H.C., additional, Lee, Y.S., additional, and Suh, D.J., additional

Published
2008
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30. Upregulation of insulin-like growth factor II may be associated with metastasis of hepatocellular carcinoma following transarterial chemoembolization

Author

Song, B.-C., primary, Chung, Y.-H., additional, Park, M.I., additional, Yang, S.H., additional, Kim, J.A., additional, Hong, I.R., additional, Choi, W.B., additional, Lee, S.S., additional, Jung, S.A., additional, Yoon, H.K., additional, Sung, K.B., additional, Lee, Y.S., additional, and Suh, D.J., additional

Published
2000
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34. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma.

Author

Lin ZZ, Hsu HC, Hsu CH, Yeh PY, Huang CY, Huang YF, Chen TJ, Kuo SH, Hsu C, Hu FC, Jeng YM, Chung Y, and Cheng AL

Subjects
Apoptosis drug effects, Aurora Kinases, Cell Division drug effects, Cell Line, Tumor, Cell Survival drug effects, Histones metabolism, Humans, Liver Neoplasms pathology, Mitosis drug effects, Antineoplastic Agents therapeutic use, Carcinoma, Hepatocellular drug therapy, Liver Neoplasms drug therapy, Piperazines therapeutic use, Protein Serine-Threonine Kinases antagonists & inhibitors
Abstract

Background/aims: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and novel therapies are urgently needed. Recently, aberrant expression of Aurora kinases has been reported in various human cancers including HCC. We sought to investigate the potential of a potent and selective Aurora kinase inhibitor, VE-465, for targeted therapy of HCC., Methods: Cytotoxicity effects of VE-465 were tested in Huh-7 and HepG2 cell lines. Inhibition of Aurora kinase activity was demonstrated by Western blotting and immunofluorescence staining. Mitotic perturbation was visualized by confocal microscopy. Cell cycle profiles and apoptosis were assessed by flow cytometry. In vivo efficacy was determined in nude mice with human HCC xenografts., Results: We demonstrated that VE-465 induced proliferation blockade, histone H3 (Ser10) dephosphorylation, mitotic disturbance, endoreduplication, and apoptosis in Huh-7 and HepG2 cells. We also found that VE-465 suppressed Aurora kinase activity, prevented tumor growth, and induced apoptosis in a Huh-7 xenograft model., Conclusions: These findings show that VE-465 has potent anticancer effects in human HCC. Inhibitors of Aurora kinases may deserve further exploration as molecular targeted agents against HCC.

Published
2009
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35. Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate.

Author

Chung YB, Miyauchi S, Sugiyama Y, Harashima H, Iga T, and Hanano M

Subjects
Anilino Naphthalenesulfonates metabolism, Animals, Anions pharmacokinetics, Biological Transport physiology, Blood Proteins metabolism, Cell Separation, Cytosol metabolism, Cytosol physiology, Cytosol ultrastructure, Liver cytology, Liver metabolism, Liver physiology, Male, Oleic Acid, Oleic Acids pharmacology, Rats, Rats, Inbred Strains, Sulfobromophthalein pharmacology, Anilino Naphthalenesulfonates blood, Anions pharmacology
Abstract

The effects of various organic anions on the hepatic transport of an anionic fluorescent dye, 1-anilino-8-naphthalene sulfonate (ANS) were investigated by measuring the plasma disappearance-time profiles in rats. Ten min after the i.v. administration of ANS (3 mumol/kg), various organic anions (60 mumol/kg) were injected in a bolus. Sulfobromophthalein (BSP), bromophenol blue (BPB) and rose bengal (RB) induced a transient increase in the plasma concentration of ANS (the so-called 'counter-transport' phenomena). The effect of rose bengal was somewhat different. After the administration of rose bengal, the plasma concentration of ANS decreased rapidly followed by a gradual increase. On the other hand, after the administration of bilirubin and taurocholate, the transient increases in plasma ANS concentrations were minimal. No effect was observed after the administration of phenolsulfophthalein (PSP) or oleate. The effects of these organic anions on the binding of ANS to rat liver cytosols were examined by equilibrium dialysis. Sulfobromophthalein, bromophenol blue and rose bengal, which yielded an in vivo 'counter-transport' phenomena, markedly inhibited ANS binding to cytosolic proteins. On the other hand, the other organic anions examined had very small, if any, inhibitory effect. The ANS binders in the cytosol were then identified by gel filtration. ANS bound mainly to X and Y (ligandin) fractions in the cytosol. Sulfobromophthalein, which is one of the organic anions exhibiting the in vivo 'counter-transport' phenomenon, remarkably inhibited ANS binding to ligandin fraction. It was thus suggested that the in vivo 'counter-transport' phenomena may be also explained by the enhancement of back diffusion due to the displacement of intracellular binding. In conclusion, one should be more cautious in interpreting data obtained from so-called in vivo 'counter-transport' experiments.

Published
1990
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