Search

Your search keyword '"Onishi, S."' showing total 18 results
Start Over Author "Onishi, S." Journal journal of hepatology
18 results on '"Onishi, S."'

1. 1305 POSITIVE ANTI-GP210 ANTIBODIES IS A RISK FACTOR FOR POOR BIOCHEMICAL RESPONSE TO URSODEOXYCHOLIC ACID TREATMENT IN JAPANESE PATIENTS WITH PRIMARY BILIARY CIRRHOSIS

Author

Nakamura, M., primary, Ito, M., additional, Yamamoto, K., additional, Zeniya, M., additional, Ohira, H., additional, Hashimoto, E., additional, Honda, M., additional, Kaneko, S., additional, Ueno, Y., additional, Kikuchi, K., additional, Onji, S., additional, Shimoda, S., additional, Takikawa, H., additional, Tanaka, A., additional, Komori, A., additional, Yatsuhashi, H., additional, Kondo, H., additional, Harada, K., additional, Onishi, S., additional, Tsubouchi, H., additional, Nakanuma, Y., additional, and Ishibashi, H., additional

Published
2011
Full Text
View/download PDF

2. 1109 POSITIVE ANTI-GP210 ANTIBODIES IS A STRONG RISK FACTOR FOR BILE DUCT LOSS AND HEPATITIS WHICH INDUCE JAUNDICE-TYPE PROGRESSION OF PRIMARY BILIARY CIRRHOSIS IN JAPANESE PATIENTS

Author

Nakamura, M., primary, Ito, M., additional, Yamamoto, K., additional, Zeniya, M., additional, Ohira, H., additional, Hashimoto, E., additional, Kaneko, S., additional, Ueno, Y., additional, Kikuchi, K., additional, Onji, M., additional, Shimoda, S., additional, Komori, A., additional, Takikawa, H., additional, Onishi, S., additional, Tsubouchi, H., additional, Ishibashi, H., additional, and Nakanuma, Y., additional

Published
2010
Full Text
View/download PDF

17. The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population.

Author

Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono M, Akisawa N, Iwasaki S, Saibara T, and Onishi S

Subjects
Adult, Alleles, DNA Primers, Fatty Liver epidemiology, Fatty Liver genetics, Female, Humans, Japan epidemiology, Male, Methionine metabolism, Middle Aged, Polymerase Chain Reaction, Valine metabolism, Asian People genetics, Gene Frequency genetics, Genetic Predisposition to Disease genetics, Phosphatidylethanolamine N-Methyltransferase genetics, Phosphatidylethanolamine N-Methyltransferase metabolism, Polymorphism, Single Nucleotide genetics
Abstract

Background/aims: The genetic predisposition on the development of nonalcoholic steatohepatitis (NASH) has been poorly understood. A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine. The aim of this study was to investigate whether the carriers of Val175Met variant impaired in PEMT activity are more susceptible to NASH., Methods: Blood samples of 107 patients with biopsy-proven NASH and of 150 healthy volunteers were analyzed by the polymerase chain reaction (PCR) and restriction fragment length polymorphism., Results: Val175Met variant allele of the PEMT gene was significantly more frequent in NASH patients than in healthy volunteers (p<0.001), and carriers of Val175Met variant were significantly more frequent in NASH patients than in healthy volunteers (p<0.01). Among NASH patients, body mass index was significantly lower (p<0.05), and non-obese patients were significantly more frequent (p<0.001) in carriers of Val175Met variant than in homozygotes of wild type PEMT., Conclusions: Val175Met variant of PEMT could be a candidate molecule that determines the susceptibility to NASH, because it is more frequently observed in NASH patients and non-obese persons with Val175Met variant of PEMT are facilitated to develop NASH.

Published
2007
Full Text
View/download PDF

18. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis.

Author

Namikawa C, Shu-Ping Z, Vyselaar JR, Nozaki Y, Nemoto Y, Ono M, Akisawa N, Saibara T, Hiroi M, Enzan H, and Onishi S

Subjects
Adult, Aldehydes metabolism, Alleles, Base Sequence, Case-Control Studies, DNA genetics, Fatty Liver pathology, Female, Gene Frequency, Hepatitis, Chronic pathology, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Syndrome, Carrier Proteins genetics, Fatty Liver genetics, Fatty Liver metabolism, Hepatitis, Chronic genetics, Hepatitis, Chronic metabolism, Polymorphism, Genetic, Superoxide Dismutase genetics
Abstract

Background/aims: The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. The aim of this study was to examine genetic influences on NASH pathogenesis., Methods: Blood samples from 63 patients with biopsy-proven NASH and 150 healthy controls were analyzed by the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Two functional polymorphisms were studied: the -493 G/T polymorphism in the promoter of microsomal triglyceride transfer protein (MTP) and the 1183 T/C polymorphism in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD)., Results: NASH patients had a much higher incidence of the MTP gene G allele (P=0.001) and of the G/G genotype (P=0.002) compared to the controls. Fat occupied more area in liver lobules and the stage of NASH was advanced in patients with the G/G-genotype than in patients with G/T-genotype (P=0.04). NASH patients also had a higher incidence of the MnSOD T/T genotype (P=0.016)., Conclusions: The G allele in the MTP promoter leads to decreased MTP transcription, less export of triglyceride from hepatocytes, and greater intracellular triglyceride accumulation. The T allele in MnSOD mitochondrial targeting sequence leads to less transport of MnSOD to the mitochondria. Therefore, functional polymorphisms in MTP and MnSOD may be involved in determining susceptibility of NASH.

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results