Search

Your search keyword '"Roncero, C."' showing total 10 results
Start Over Author "Roncero, C." Journal journal of hepatology
10 results on '"Roncero, C."'

1. Restrictions for reimbursement of interferon-free direct-acting antiviral therapies for HCV infection in Europe

Author

Marshall, A.D., primary, Nielsen, S., additional, Cunningham, E.B., additional, Aghemo, A., additional, Alho, H., additional, Backmund, M., additional, Bruggmann, P., additional, Dalgard, O., additional, Flisiak, R., additional, Foster, G., additional, Gheorghe, L., additional, Goldberg, D., additional, Goulis, I., additional, Hickman, M., additional, Hoffmann, P., additional, Jancorienė, L., additional, Jarčuška, P., additional, Kåberg, M., additional, Makara, M., additional, Maimets, M., additional, Marinho, R., additional, Matičič, M., additional, Norris, S., additional, Olafsson, S., additional, Øvrehus, A., additional, Pawlotsky, J.-M., additional, Pocock, J., additional, Robaeys, G., additional, Roncero, C., additional, Simonova, M., additional, Sperl, J., additional, Tait, M., additional, Tolmane, I., additional, Tomaselli, S., additional, van der Valk, M., additional, Vince, A., additional, Dore, G.J., additional, Lazarus, J.V., additional, and Grebely, J., additional

Published
2017
Full Text
View/download PDF

2. A novel role for BMP9 as a negative regulator of oval cell-mediated regeneration in response to liver damage

Author

Addante, A., primary, Roncero, C., additional, Almalé, L., additional, Lazcanoiturburu, N., additional, Álvaro, M.G., additional, Fernández, M., additional, Sanz, J., additional, Saperas, P., additional, Lee, S.-J., additional, Fabregat, I., additional, ten Dijke, P., additional, Dooley, S., additional, Herrera, B., additional, and Sánchez, A., additional

Published
2017
Full Text
View/download PDF

10. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.

Author

Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fernández M, and Fabregat I

Subjects
Animals, Apoptosis drug effects, Cell Line, Tumor, Fetus cytology, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genes, Reporter, Hepatocytes cytology, Hepatocytes drug effects, Humans, NADPH Oxidase 4, NADPH Oxidases metabolism, RNA, Small Interfering, Rats, Rats, Wistar, Signal Transduction drug effects, Signal Transduction physiology, Transcription, Genetic drug effects, Transcription, Genetic physiology, Up-Regulation drug effects, Up-Regulation physiology, Apoptosis physiology, Carcinoma, Hepatocellular pathology, Hepatocytes enzymology, Liver Neoplasms pathology, NADPH Oxidases genetics, Transforming Growth Factor beta pharmacology
Abstract

Background/aims: The transforming growth factor-beta (TGF-beta) induces apoptosis in hepatocytes through an oxidative stress process. Here, we have analyzed the role of different NADPH oxidase isoforms in the intracellular signalling induced by TGF-beta in hepatocytes, to later explore whether this mechanism is altered in liver tumor cells., Methods: Primary cultures of rat and human hepatocytes, HepG2 and Hep3B cells were used in in vitro studies to analyze the TGF-beta response., Results: TGF-beta-induced apoptosis in rat hepatocytes does not require Rac-dependent NADPH oxidases. TGF-beta upregulates the Rac-independent Nox4, which correlates with its pro-apoptotic activity. Regulation of Nox4 occurs at the transcriptional level and is counteracted by intracellular survival signals. siRNA targeted knock-down of Nox4 attenuates NADPH oxidase activity, caspase activation and cell death in rat hepatocytes. NOX4 upregulation by TGF-beta is also observed in human hepatocytes, coincident with apoptosis. In human hepatocellular carcinoma (HCC) cell lines, NOX4 upregulation by TGF-beta is only observed in cells that are sensitive to its cytotoxic effect, such as Hep3B cells. siRNA targeted knock-down of NOX4 in these cells impairs TGF-beta-induced apoptosis., Conclusions: Upregulation of NOX4 by TGF-beta is required for its pro-apoptotic activity in hepatocytes. Impairment of this TGF-beta-induced response might confer apoptosis resistance in HCC cells.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results