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Your search keyword '"Wang, Hong-Yang"' showing total 11 results
Start Over Author "Wang, Hong-Yang" Journal journal of hepatology
11 results on '"Wang, Hong-Yang"'

1. Novel, high accuracy prediction models of hepatocellular carcinoma based on longitudinal data and cell-free DNA signatures

Author

Fan, Rong, primary, Chen, Lei, additional, Yang, Hao, additional, Zhao, Siru, additional, Li, Zhengmao, additional, Qian, Yunsong, additional, Ma, Hong, additional, Liu, Jingfeng, additional, Niu, Junqi, additional, Wang, Chuanxin, additional, Bai, Jian, additional, Xie, Jianping, additional, Fan, Xiaotang, additional, Xie, Qing, additional, Wang, Chunying, additional, Yang, Song, additional, Bai, Honglian, additional, Dou, Xiaoguang, additional, Wu, Lin, additional, Jiang, Guoqing, additional, Xia, Qi, additional, Zheng, Dan, additional, Rao, Huiying, additional, Xia, Jie, additional, Shang, Jia, additional, Gao, Pujun, additional, Xie, Dong-Ying, additional, Yu, Yanlong, additional, Yang, Yongfeng, additional, Gao, Hongbo, additional, Liu, Yali, additional, Sun, Aimin, additional, Jiang, Yongfang, additional, Yu, Yan-Yan, additional, Sun, Jian, additional, Wang, Hong-Yang, additional, and Hou, Jinlin, additional

Published
2023
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2. OS-033 - Novel, high accuracy prediction models of hepatocellular carcinoma based on longitudinal data and cell-free DNA signatures

Author

Fan, Rong, Chen, Lei, Yang, Hao, Zhao, Siru, Li, Zhengmao, Qian, Yunsong, Ma, Hong, Liu, Jingfeng, Niu, Junqi, Wang, Chuanxin, Bai, Jian, Xie, Jianping, Fan, Xiaotang, Xie, Qing, Wang, Chunying, Yang, Song, Bai, Honglian, Dou, Xiaoguang, Wu, Lin, Jiang, Guoqing, Xia, Qi, Zheng, Dan, Rao, Huiying, Xia, Jie, Shang, Jia, Gao, Pujun, Xie, Dong-Ying, Yu, Yanlong, Yang, Yongfeng, Gao, Hongbo, Liu, Yali, Sun, Aimin, Jiang, Yongfang, Yu, Yan-Yan, Sun, Jian, Wang, Hong-Yang, and Hou, Jinlin

Published
2023
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5. ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α

Author

Wu, Fu-Quan, primary, Fang, Tian, additional, Yu, Le-Xing, additional, Lv, Gui-Shuai, additional, Lv, Hong-Wei, additional, Liang, Dong, additional, Li, Ting, additional, Wang, Chang-Zheng, additional, Tan, Ye-Xiong, additional, Ding, Jin, additional, Chen, Yao, additional, Tang, Liang, additional, Guo, Lin-Na, additional, Tang, Shan-Hua, additional, Yang, Wen, additional, and Wang, Hong-Yang, additional

Published
2016
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6. All-trans retinoic acid potentiates the chemotherapeutic effect of cisplatin by inducing differentiation of tumor initiating cells in liver cancer

Author

Zhang, Yang, primary, Guan, Dong-xian, additional, Shi, Jie, additional, Gao, Hong, additional, Li, Jing-jing, additional, Zhao, Jiang-sha, additional, Qiu, Lin, additional, Liu, Jiang, additional, Li, Nan, additional, Guo, Wei-xing, additional, Xue, Jie, additional, Zhou, Fei-guo, additional, Wu, Meng-chao, additional, Wang, Hong-yang, additional, Xie, Dong, additional, and Cheng, Shu-qun, additional

Published
2013
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8. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats

Author

Zhang, Hui-Lu, primary, Yu, Le-Xing, additional, Yang, Wen, additional, Tang, Liang, additional, Lin, Yan, additional, Wu, Han, additional, Zhai, Bo, additional, Tan, Ye-Xiong, additional, Shan, Lei, additional, Liu, Qiong, additional, Chen, Hai-Yang, additional, Dai, Rong-Yang, additional, Qiu, Bi-Jun, additional, He, Ya-Qin, additional, Wang, Chao, additional, Zheng, Long-Yi, additional, Li, Yu-Qiong, additional, Wu, Fu-Quan, additional, Li, Zhong, additional, Yan, He-Xin, additional, and Wang, Hong-Yang, additional

Published
2012
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9. OV6+ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma

Author

Yang, Wen, primary, Wang, Chao, additional, Lin, Yan, additional, Liu, Qiong, additional, Yu, Le-xing, additional, Tang, Liang, additional, Yan, He-Xin, additional, Fu, Jing, additional, Chen, Yao, additional, Zhang, Hui-Lu, additional, Zheng, Long-Yi, additional, He, Ya-Qin, additional, Li, Yu-Qiong, additional, Wu, Fu-Quan, additional, Zou, Shan-Shan, additional, Li, Zhong, additional, Wu, Meng-Chao, additional, Feng, Gen-Sheng, additional, and Wang, Hong-Yang, additional

Published
2012
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11. OV6+ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma

Author

Yang, Wen, Wang, Chao, Lin, Yan, Liu, Qiong, Yu, Le-xing, Tang, Liang, Yan, He-Xin, Fu, Jing, Chen, Yao, Zhang, Hui-Lu, Zheng, Long-Yi, He, Ya-Qin, Li, Yu-Qiong, Wu, Fu-Quan, Zou, Shan-Shan, Li, Zhong, Wu, Meng-Chao, Feng, Gen-Sheng, and Wang, Hong-Yang

Subjects
*LIVER cancer, *CANCER invasiveness, *STROMAL cells, *CXCR4 receptors, *REVERSE transcriptase polymerase chain reaction, *KAPLAN-Meier estimator, *METASTASIS
Abstract

Background & Aims: Accumulating evidence suggests the involvement of tumor-initiating cells (T-ICs) in cancer genesis, but whether liver T-ICs contribute to HCC invasion and metastasis remains unclear. Methods: OV6+ T-ICs were isolated from SMMC7721 and HuH7 cell lines by magnetic sorting. Characteristics of T-ICs were assessed by in vitro and mouse xenograft assays. Expression of OV6 was determined by immunostaining in specimens from 218 HCC patients, and Kaplan–Meier survival analysis was used to determine the correlation of OV6 expression with prognosis. Results: OV6+ T-ICs isolated from HCC cell lines not only possess a higher capacity to form tumor spheroids in vitro, but also had a greater potential to form tumors when implanted in non-obese diabetic/severe combined immunodeficient mice, suggesting their elevated self-renewal capacity and tumorigenicity. Moreover, OV6+ T-ICs exhibited more invasive and metastatic potentials both in vitro and in vivo. Patients with more OV6+ tumor cells were associated with aggressive clinicopathologic features and poor prognosis. CXCR4 is expressed at higher levels in OV6+ cells. Recombinant stromal cell-derived factor-1 (SDF-1) treatment expanded the OV6+ HCC T-ICs population, by sustaining the stem cell property of OV6+ cells. The SDF-1 effect was blocked by a specific CXCR4 inhibitor, AMD3100, or transfection of siRNA targeting CXCR4. Conclusions: OV6+ HCC cells may represent a subpopulation of T-ICs with augmented invasion and metastasis potential, which contribute to progression and metastasis of HCC. The SDF-1/CXCR4 axis also provides therapeutic targets for elimination of liver T-ICs. [ABSTRACT FROM AUTHOR]

Published
2012
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