Search

A safer, greener, and more effective reaction methodology for the synthesis of dihydroquinazolinones (DHQs) has been developed. The deep eutectic solvent (DES) ZnCl2/urea employed in this study efficiently accelerated the cyclization of 2‐aminobenzamide with different aldehydes (aromatic and heteroaromatic) to afford the target scaffolds without the generation of any oxidized product. This method has exhibited remarkable advantages such as quick reaction time, mild reaction conditions, high yield (82%–98%), operational simplicity, and selectivity. The approach was observed to be tolerant to electron‐donating and electron‐withdrawing functional groups. Green metric parameters (AEf, OE, AE, RME, CE, etc.) determined further aided this greener chemical approach. [ABSTRACT FROM AUTHOR]

Pyrrolin‐4‐ones/pyrrolin‐3‐ones and its derivatives are important heterocyclic systems which are observed in vast variety of natural products, pharmaceuticals, and biologically important compounds. Different researchers all across the world have developed different synthetic methodologies for the construction of functionalized pyrrolin‐4‐ones/pyrrolin‐3‐one scaffolds such as the transition‐metal catalyzed/mediated cycloisomerizations of 1‐aminoynones and dimerization of enaminones or α‐diazo‐β‐oxoamides etc. The present review article summarizes various reports on the synthesis of various simple and functionalized pyrrolin‐4‐ones/pyrrolin‐3‐ones from 2000 onward. [ABSTRACT FROM AUTHOR]

The reactions of butadienylketene with variety of 1,4-diazabuta-1,3-dienes are studied. The reactions resulted in the formation of previously unknown functionalized cis butadienyl-4-iminomethyl-azetidin-2-ones and butenylidene-butadienyl-[2,2′-biazetidine]-4,4′- diones. Butadienyl ketene reacts in fashion with both iminic portion of 1,4- diazabuta-1,3-dienes and competitive [4+2] of 1,4-diazabuta-1,3-dienes as 4π component with butadienyl ketene as 2π component are not observed. [ABSTRACT FROM AUTHOR]