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This article presents a synthetic method and reaction mechanism of the 1,5-benzothiazepines and 1,5-benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven-membered rings) have also been determined and compared with thiazine (six-membered ring). In this method, N-methylimidazolium nitrate [Hmim][NO3] has been used as a catalyst that acts as an environmental friendly system.

An efficient method for the synthesis of a series of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones is described via one-pot condensation reaction of isatoic anhydride, aryl aldehydes, and primary amines using a Bronsted acidic ionic liquid, [Hmim][NO3], as a catalyst and medium. The present protocol enjoys convenient reaction and simple work-up, greenness, short reaction times, and reusable catalyst as well as mild reaction conditions. J. Heterocyclic Chem., (2011).

Molten tetra-n-butylphosphonium bromide is found to be a practical and inexpensive catalytic media for stereoselective one-pot synthesis of pyranoquinoline and furanoquinoline derivatives in good to excellent yields. Products of undesirable reactions resulting from polymerization are not observed. The use of this catalyst media avoids the use of any cocatalysts or toxic organic solvents. J. Heterocyclic Chem., (2011).

An efficient and practical procedure for direct synthesis of 3,5-diaryl-1,2,4-thiadiazoles by thioamides with 2,4,6-trichloro-1,3,5-triazine (TCT) and dimethylsulfoxide using 1-butyl-3-methylimidazolium tetrafluoroborate as an eco-friendly reaction medium under ambient temperature is described. This protocol can be considered as a new procedure for 3,5-diaryl-1,2,4-thiadiazoles synthesis. J. Heterocyclic Chem., (2010).

A new, facile, efficient, “green” and chemoselective procedure for the synthesis of indole derivatives has been developed with pulverization-activation method catalyzed by Bi(NO3)3·5H2O (PAMC- Bi(NO3)3·5H2O) through grinding of indoles with aldehydes or Michael acceptors in the presence of catalytic amounts of Bi(NO3)3·5H2O under solvent-free conditions.