1. Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism
- Author
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Chol Shin, Hyung Lae Kim, Seong Gu Heo, Hocheol Shin, Yeon Ah Sung, Min Jung Kwon, Juhee Cho, Seungho Ryu, Song E. Kim, Yoosoo Chang, Han Na Kim, Yeo Jun Yun, and Nam H. Cho
- Subjects
0301 basic medicine ,Adult ,Male ,Genotype ,media_common.quotation_subject ,Hostility ,Genome-wide association study ,Biology ,Impulsivity ,Polymorphism, Single Nucleotide ,Revised NEO Personality Inventory ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Quantitative Trait, Heritable ,mental disorders ,Genetics ,medicine ,Personality ,Humans ,Genetics (clinical) ,Alleles ,media_common ,Aged ,Neuroticism ,Chromosome Mapping ,Middle Aged ,030104 developmental biology ,Facet (psychology) ,Anxiety ,Original Article ,Female ,medicine.symptom ,030217 neurology & neurosurgery ,Genome-Wide Association Study ,Signal Transduction - Abstract
Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: anxiety, N2: angry hostility, N3: depression, N4: self-consciousness, N5: impulsivity and N6: vulnerability) were assessed using the Korean version of the Revised NEO Personality Inventory. In the single-nucleotide polymorphism-based analysis, results showed genome-wide significance for N2 within the MIR548H3 gene (rs1360001, P=4.14 × 10-9). Notable genes with suggestive associations (P
- Published
- 2017