1. Heritability of ambulatory and office blood pressure in the Swiss population
- Author
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Kei Asayama, Belen Ponte, Fred Paccaud, Heba Alwan, Daniel Ackermann, Zoltán Kutalik, Idris Guessous, Antoinette Pechère-Bertschi, Bruno Vogt, Pierre-Yves Martin, Murielle Bochud, Jan A. Staessen, Georg Ehret, Markus G. Mohaupt, Philippe Vuistiner, Menno Pruijm, Michel Burnier, Epidemiologie, and RS: CARIM - R3 - Vascular biology
- Subjects
Adult ,Male ,cross-sectional ,Ambulatory blood pressure ,Blood Pressure/genetics ,Physiology ,Population ,population ,White coat hypertension ,610 Medicine & health ,Blood Pressure ,030204 cardiovascular system & hematology ,heritability ,03 medical and health sciences ,0302 clinical medicine ,Switzerland/epidemiology ,Internal Medicine ,medicine ,Humans ,education ,Hypertension/epidemiology/genetics ,White Coat Hypertension/epidemiology/genetics ,ambulatory blood pressure ,030304 developmental biology ,ddc:613 ,ddc:616 ,0303 health sciences ,education.field_of_study ,business.industry ,Blood Pressure Determination ,Heritability ,500 Science ,Middle Aged ,medicine.disease ,3. Good health ,Pulse pressure ,Blood pressure ,Genetic epidemiology ,Ambulatory ,Hypertension ,570 Life sciences ,biology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Switzerland ,White Coat Hypertension ,Demography - Abstract
BACKGROUND Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. METHODS The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. RESULTS The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 ± 0.07, 0.26 ± 0.07, and 0.29 ± 0.07 for 24-h BP; 0.39 ± 0.07, 0.28 ± 0.07, and 0.27 ± 0.07 for day BP; and 0.25 ± 0.07, 0.20 ± 0.07, and 0.30 ± 0.07 for night BP, respectively (all P
- Published
- 2015
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