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Your search keyword '"Morris, Brian J."' showing total 28 results
Start Over Author "Morris, Brian J." Journal journal of hypertension
28 results on '"Morris, Brian J."'

16. Short report

Author

Zee, Robert Y.L., primary, Lou, Yi-kun, additional, and Morris, Brian J., additional

Published
1993
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22. Kallikrein genes.

Author

Schedlich, Lynette J., Catanzaro, Daniel F., and Morris, Brian J.

Published
1988

24. No association with hypertension of CLCNKBand TNFRSF1Bpolymorphisms at a hypertension locus on chromosome 1p36

Author

Speirs, Helen JL, Wang, William YS, Benjafield, Adam V, and Morris, Brian J

Abstract

Chromosome 1p36 has been linked to essential hypertension and systolic blood pressure. This locus contains the chloride channel-Kb gene (CLCNKB) and the tumour necrosis factor receptor 2 gene (TNFRSF1B). Polymorphisms of each of these have shown association with hypertension, and a CLCNKBT481S variant alters receptor function. Here we performed association studies in a well-characterized cohort of hypertensives and normotensives whose blood pressure status matched that of both their parents.

Published
2005
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28. FOXO3 longevity genotype attenuates the impact of hypertension on cerebral microinfarct risk.

Author

Nakagawa K, Chen R, Ross GW, Donlon TA, Allsopp RC, Willcox DC, Morris BJ, Willcox BJ, and Masaki KH

Subjects
Male, Humans, Prospective Studies, Genotype, Alleles, Forkhead Box Protein O3 genetics, Longevity genetics, Hypertension complications, Hypertension genetics
Abstract

Objective: The G -allele of FOXO3 SNP rs2802292 , which is associated with human resilience and longevity, has been shown to attenuate the impact of hypertension on the risk of intracerebral hemorrhage (ICH). We sought to determine whether the FOXO3 G -allele similarly attenuates the impact of hypertension on the risk of cerebral microinfarcts (CMI)., Methods: From a prospective population-based cohort of American men of Japanese ancestry from the Kuakini Honolulu Heart Program (KHHP) and Kuakini Honolulu-Asia Aging Study (KHAAS) that had brain autopsy data, age-adjusted prevalence of any CMI on brain autopsy was assessed. Logistic regression models, adjusted for age at death, cardiovascular risk factors, FOXO3 and APOE-ε4 genotypes, were utilized to determine the predictors of any CMI. Interaction of FOXO3 genotype and hypertension was analyzed., Results: Among 809 men with complete data, 511 (63.2%) participants had evidence of CMI. A full multivariable model demonstrated that BMI [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.14, P  = 0.015) was the only predictor of CMI, while hypertension was a borderline predictor (OR 1.44, 95% CI 1.00-2.08, P  = 0.052). However, a significant interaction between FOXO3 G -allele carriage and hypertension was observed ( P  = 0.020). In the stratified analyses, among the participants without the longevity-associated FOXO3 G -allele, hypertension was a strong predictor of CMI (OR 2.25, 95% CI 1.34-3.77, P  = 0.002), while among those with the longevity-associated FOXO3 G -allele, hypertension was not a predictor of CMI (OR 0.88, 95% CI 0.51-1.54, P  = 0.66)., Conclusion: The longevity-associated FOXO3 G -allele mitigates the impact of hypertension on the risk of CMI., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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