1. Urinary sodium-to-potassium ratio and plasma renin and aldosterone concentrations in normotensive children: implications for the interpretation of results
- Author
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Carlos E. Fardella, Sofia Sifaqui, Maria Rodriguez-Fernandez, Ivonne D'Apremont, Hernan Garcia, Rene Baudrand, Rosario Moore, Claudia Trincado, Jose Tomas Ossa, Fidel Allende, Monica Arancibia, Sandra Solari, Carmen Campino, Helena Poggi, Alejandro Martinez-Aguayo, Cristian A. Carvajal, and Soledad Peredo
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Urinary system ,Potassium ,chemistry.chemical_element ,Blood Pressure ,Urine ,030204 cardiovascular system & hematology ,Plasma renin activity ,Renin-Angiotensin System ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Renin ,Internal Medicine ,Medicine ,Humans ,030212 general & internal medicine ,Child ,Aldosterone ,business.industry ,Sodium ,Gestational age ,Nomogram ,Healthy Volunteers ,Blood pressure ,Endocrinology ,chemistry ,Child, Preschool ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES To identify associations among the plasma renin concentration (PRC), plasma aldosterone and urinary sodium (Na)/potassium (K) ratio, and to integrate these variables into a nomogram with the aim of estimating the expected versus observed aldosterone concentration. METHODS We studied 40 healthy normotensive children (5-8 years old, 57.5% girls) who were born at term and were adequate for their gestational age. Following overnight fasting, the PRC and plasma aldosterone in blood samples were measured, and the Na/K ratio was calculated from a simultaneously obtained urinary spot sample. A mathematical function was defined with these three variables, and a nomogram was built that would return the expected aldosterone concentration from the obtained plasma renin and urinary Na/K ratio values. RESULTS The PRC (B = 5.9, P
- Published
- 2019