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Start Over Author "Thom, Simon" Journal journal of hypertension
12 results on '"Thom, Simon"'

5. Measurement of pulse wave velocity: site matters

Author

Tillin, Therese, primary, Chambers, John, additional, Malik, Iqbal, additional, Coady, Emma, additional, Byrd, Sheila, additional, Mayet, Jamil, additional, Wright, Andrew R, additional, Kooner, Jaspal, additional, Shore, Angela, additional, Thom, Simon, additional, Chaturvedi, Nish, additional, and Hughes, Alun, additional

Published
2007
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6. Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension

Author

Hughes, Alun D, primary, Martinez-Perez, Elena, additional, Jabbar, Abu-Sufian, additional, Hassan, Assif, additional, Witt, Nick W, additional, Mistry, Paresh D, additional, Chapman, Neil, additional, Stanton, Alice V, additional, Beevers, Gareth, additional, Pedrinelli, Roberto, additional, Parker, Kim H, additional, and Thom, Simon A McG, additional

Published
2006
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8. Retinal vascular network architecture in low-birth-weight men

Author

Chapman, Neil, primary, Mohamudally, Anthoulla, additional, Cerutti, Alessia, additional, Stanton, Alice, additional, Sayer, Avan Aihie, additional, Cooper, Cyrus, additional, Barker, David, additional, Rauf, Abdul, additional, Evans, Jennifer, additional, Wormald, Richard, additional, Sever, Peter, additional, Hughes, Alun, additional, and Thom, Simon, additional

Published
1997
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10. Retinal vascular network architecture in lowbirthweight men

Author

Chapman, Neil, Mohamudally, Anthoulla, Cerutti, Alessia, Stanton, Alice, Sayer, Avan Aihie, Cooper, Cyrus, Barker, David, Rauf, Abdul, Evans, Jennifer, Wormald, Richard, Sever, Peter, Hughes, Alun, and Thom, Simon

Abstract

Low birth weight is associated with hypertension and increased cardiovascular mortality, but the mechanism of this association is not known. Hypertension is accompanied by abnormalities of the microvasculature including rarefaction.

Published
1997

12. Size and sitedependent heterogeneity of human vascular responses in vitro

Author

Hughes, Alun D., Thom, Simon A.M., Martin, Glenn N., Nielsen, Henrik, Hair, W. Morton, Schachter, Michael, and Sever, Peter S.

Abstract

Ring segments of splanchnic, peripheral, coronary, pulmonary and uterine conduit arteries obtained during surgery were studied in tissue baths. Resistance arteries dissected from various sites were studied in a myograph. Both conduit and resistance vessels contracted in response to the α1-agonist phenylephrine (10-7to 10-4mol/l), an effect that was antagonized by the α1-antagonist doxazosin (10-8to 10-6mol/l). However, the α2-agonists BHT 933 (10-7to 10-4mol/l) and UK 14304 (10-7to 10-4mol/l) only contracted the resistance vessels and not the conduit arteries. The response to BHT 933 was competitively antagonized by the α2-antagonist yohimbine (3.10-8to 3.10-7mol/l) and the magnitude of the contractile response was inversely related to vessel size. Similarly, neuropeptide Y (10-9to 10-6mol/l) contracted only the resistance vessels, and induced marked tachyphylaxis. Atrial natriuretic peptide (ANP; 10-8to 10-6mol/l) produced concentration-dependent relaxation in all conduit arteries studied, being ineffective in resistance arteries from subcutaneous or omental sites, but relaxed those from renal tissue and skeletal muscle. Calcitonin gene-related peptide (10-8to 10-6mol/l) and vasoactive intestinal peptide (10-9to 10-6mol/l) relaxed both conduit and resistance arteries. This response was dependent on the integrity of the endothelium in the systemic conduit but not the resistance vessels. These results indicate that the receptors for adrenergic agonists and vasoactive peptides are varyingly distributed throughout the human vasculature. The physiological relevance of these observations is not yet clear, but it is clearly important to the investigation of the sites of action of vasodilator drugs.

Published
1988

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