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Your search keyword '"MESH: Immune Tolerance"' showing total 2 results
Start Over Descriptor "MESH: Immune Tolerance" Journal journal of immunology (baltimore, md. : 1950)
2 results on '"MESH: Immune Tolerance"'

1. Immune tolerance induction with multiepitope peptide derived from citrullinated autoantigens attenuates arthritis manifestations in adjuvant arthritis rats

Author

Howard Amital, Yehuda Shoenfeld, Smadar Gertel, Guy Serre, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CARBILLET, Véronique, and Tel Aviv University (TAU)

Subjects
Arthritis, MESH: Autoantigens / immunology, Apoptosis, Filaggrin Proteins, Autoantigens, Severity of Illness Index, T-Lymphocytes, Regulatory, Immune tolerance, Arthritis, Rheumatoid, Epitopes, 0302 clinical medicine, MESH: Arthritis, Rheumatoid / immunology, MESH: Citrulline / metabolism, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, T-Lymphocyte Subsets, MESH: Arthritis, Rheumatoid / pathology, Immunology and Allergy, MESH: Animals, MESH: T-Lymphocyte Subsets / metabolism, 0303 health sciences, MESH: Epitopes / metabolism, 3. Good health, Tolerance induction, medicine.anatomical_structure, Phenotype, MESH: Peptides / administration & dosage, MESH: Epitopes / immunology, Rheumatoid arthritis, MESH: T-Lymphocyte Subsets / immunology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Filaggrin, MESH: Immune Tolerance, MESH: Immunophenotyping, MESH: Rats, Regulatory T cell, MESH: T-Lymphocytes, Regulatory / metabolism, T cell, Immunology, MESH: Autoantibodies / immunology, MESH: Peptides / immunology, MESH: Phenotype, MESH: Autoantigens / metabolism, MESH: Apoptosis / immunology, Immunophenotyping, 03 medical and health sciences, MESH: Severity of Illness Index, medicine, Immune Tolerance, Animals, 030304 developmental biology, Autoantibodies, 030203 arthritis & rheumatology, MESH: Arthritis, Experimental / immunology, business.industry, Autoantibody, medicine.disease, Arthritis, Experimental, Rats, MESH: T-Lymphocytes, Regulatory / immunology, Disease Models, Animal, MESH: Peptides / metabolism, MESH: Epitopes / administration & dosage, MESH: Arthritis, Experimental / pathology, Citrulline, MESH: Disease Models, Animal, business, Peptides, MESH: Female
Abstract

Citrullinated peptides are major targets of disease-specific autoantibodies in rheumatoid arthritis. Currently, citrullinated peptides are used as biomarkers for diagnosing rheumatoid arthritis by measuring anti-citrullinated protein Ab (ACPA) titers in patients’ sera. The accumulation of citrullinated proteins at synovial inflammation sites suggests that they are possible targets for tolerance induction. The objective of the present study was to determine whether citrullinated peptides could induce tolerance in an experimental arthritis model in rats. In view of the multiplicity of target citrullinated autoantigens described for ACPA, we generated a multiepitope citrullinated peptide (Cit-ME), derived from major prevalent citrullinated autoantigens (citrullinated filaggrin, fibrinogen, vimentin, and collagen type II), and studied its effects on arthritic rats. Adjuvant-induced arthritis was induced in Lewis rats. Beginning at day 7 after disease induction, the rats received eight s.c. injections of Cit-ME on alternate days. Differences in clinical status and modulation of T cell populations were analyzed. In adjuvant-induced arthritis rats treated with Cit-ME, disease severity was significantly reduced compared with that of untreated rats. Moreover, amelioration of disease manifestations was related to an increased regulatory T cell subset and an elevated apoptosis rate of T cells associated with reduced Th17 cells. Thus, the use of citrullinated peptides–based immunotherapy may be a promising approach for tolerance induction in experimental arthritis and perhaps even in susceptible individuals that are ACPA-seropositive in human arthritis.

Published
2014

2. Existence of CD8α-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species

Author

Rachel Guiton, Karine Crozat, Yannick O. Alexandre, Marc Dalod, Vanessa Contreras, Michel Bonneau, Thibault Andrieu, Thien-Phong Vu Manh, Isabelle Schwartz-Cornil, Mathieu Epardaud, Ariel Savina, Nicolas Bertho, Jayne Hope, Luc Jouneau, Céline Urien, Sebastian Amigorena, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Immunologie de Marseille Luminy (CIML - INSERM U631 - CNRS UMR 6102), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Energie Atomique, Di- vision of Immuno-Virology, Direction des Sciences du Vivant, Institut des Maladies Emergentes et des The´rapies Innovantes, Fontenay-aux-Rose, Institute for Animal Health, Compton, Institut Curie, PSL Research University, INSERM U932., Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institute for Animal Health (IAH), Biotechnology and Biological Sciences Research Council, Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Imagerie Interventionnelle (CR2I), Unité de recherche Virologie et Immunologie Moléculaires ( VIM ), Institut National de la Recherche Agronomique ( INRA ), Centre d'Immunologie de Marseille - Luminy ( CIML ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Institut des Maladies Emergentes et des Thérapies Innovantes ( IMETI ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Institute for Animal Health ( IAH ), Immunité et cancer ( U932 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche en Imagerie Interventionnelle ( CR2I ), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Biotechnology and Biological Sciences Research Council (BBSRC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie-Université Paris Descartes - Paris 5 (UPD5)

Subjects
[SDV]Life Sciences [q-bio], Conserved sequence, Immune tolerance, Interleukin 22, Mice, 0302 clinical medicine, Immunology and Allergy, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH : Female, MESH: Animals, Domestic, Cells, Cultured, Conserved Sequence, Skin, 0303 health sciences, Cultured, MESH: Conserved Sequence, MESH: Dendritic Cells, MESH : Immune Tolerance, hemic and immune systems, Phenotype, Cell biology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Lymph, MESH: Cells, Cultured, MESH: Lymph, XCR1, MESH: Immune Tolerance, Cells, CD8 Antigens, Dipeptidyl Peptidase 4, Immunology, chemical and pharmacologic phenomena, Biology, MESH : Lymph, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Skin, Species Specificity, MESH : Conserved Sequence, MESH : Mice, MESH : Sheep, Domestic, MESH : Cells, Cultured, MESH : Skin, Immune Tolerance, MESH : Species Specificity, MESH: Species Specificity, Animals, Humans, Antigens, Gene, MESH: Mice, Sheep, Domestic, 030304 developmental biology, Sheep, MESH: Humans, MESH : Gene Expression Profiling, Gene Expression Profiling, MESH : Humans, CD8, Dendritic cell, Dendritic Cells, MESH: Dipeptidyl Peptidase 4, MESH : Dendritic Cells, MESH : Dipeptidyl Peptidase 4, MESH : Animals, MESH: Antigens, CD8, MESH: Sheep, Domestic, MESH : Antigens, CD8, MESH: Female, 030215 immunology
Abstract

International audience; The mouse lymphoid organ-resident CD8alpha(+) dendritic cell (DC) subset is specialized in Ag presentation to CD8(+) T cells. Recent evidence shows that mouse nonlymphoid tissue CD103(+) DCs and human blood DC Ag 3(+) DCs share similarities with CD8alpha(+) DCs. We address here whether the organization of DC subsets is conserved across mammals in terms of gene expression signatures, phenotypic characteristics, and functional specialization, independently of the tissue of origin. We study the DC subsets that migrate from the skin in the ovine species that, like all domestic animals, belongs to the Laurasiatheria, a distinct phylogenetic clade from the supraprimates (human/mouse). We demonstrate that the minor sheep CD26(+) skin lymph DC subset shares significant transcriptomic similarities with mouse CD8alpha(+) and human blood DC Ag 3(+) DCs. This allowed the identification of a common set of phenotypic characteristics for CD8alpha-like DCs in the three mammalian species (i.e., SIRP(lo), CADM1(hi), CLEC9A(hi), CD205(hi), XCR1(hi)). Compared to CD26(-) DCs, the sheep CD26(+) DCs show 1) potent stimulation of allogeneic naive CD8(+) T cells with high selective induction of the Ifngamma and Il22 genes; 2) dominant efficacy in activating specific CD8(+) T cells against exogenous soluble Ag; and 3) selective expression of functional pathways associated with high capacity for Ag cross-presentation. Our results unravel a unifying definition of the CD8alpha(+)-like DCs across mammalian species and identify molecular candidates that could be used for the design of vaccines applying to mammals in general.

Published
2010

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