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Start Over Topic cd11c Publication Year Range Last 50 years Journal journal of immunotoxicology
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1. CD11c decrease in mouse thymic dendritic cells after vanadium inhalation.

Author

Ustarroz-Cano, M., García-Peláez, I., Piñón-Zárate, G., Herrera-Enríquez, M., Soldevila, G., and Fortoul, T. I.

Subjects
DENDRITIC cells, TRANSITION metals, RESPIRATORY therapy, PHYSIOLOGICAL effects of vanadium, IMMUNE response, IMMUNOHISTOCHEMISTRY, THYMUS
Abstract

Vanadium (V) is a transition metal found in air adsorbed onto suspended particles. As a result, urban populations are often exposed to this element as a constituent of particulate matter (PM). One aspect of the myriad toxicities that might arise from these exposures is altered immune responses. Previous reports from the laboratory reported modifications in splenic architecture - with germinal center hyperplasia and a suppressed humoral immune response - in mice that had been exposed to vanadium agents via inhalation. This paper reports a decrease in the presence of the CD11c surface marker on mouse thymic dendritic cells (DC) as a result of host exposure to vanadium (here, in the form of vanadium pentoxide; V2O5) over a period of 4 weeks. All results were obtained using immunohistochemistry and flow cytometry. It is surmised that this decrease might induce a dysfunction, including possible negative selection of T-cells, which could increase the presence of autoreactive clones in the exposed host. Such an outcome could, in turn, increase the risk for development of autoimmune reactions in different organs specifically, and of autoimmune diseases in general in these V-exposed hosts. [ABSTRACT FROM AUTHOR]

Published
2012
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2. CD11c decrease in mouse thymic dendritic cells after vanadium inhalation

Author

Isabel García-Peláez, Miguel Ángel Herrera-Enríquez, Gabriela Piñón-Zárate, Martha Ustarroz-Cano, Teresa I. Fortoul, and Gloria Soldevila

Subjects
Male, Immunology, Vanadium, chemistry.chemical_element, CD11c, Down-Regulation, Mice, Inbred Strains, Cell Separation, Thymus Gland, Toxicology, Flow cytometry, Autoimmune Diseases, Mice, Immune system, medicine, Animals, Cells, Cultured, Air Pollutants, medicine.diagnostic_test, Inhalation, Germinal center, Dendritic Cells, Environmental Exposure, Hyperplasia, medicine.disease, Flow Cytometry, Molecular biology, CD11c Antigen, chemistry, Immunohistochemistry
Abstract

Vanadium (V) is a transition metal found in air adsorbed onto suspended particles. As a result, urban populations are often exposed to this element as a constituent of particulate matter (PM). One aspect of the myriad toxicities that might arise from these exposures is altered immune responses. Previous reports from the laboratory reported modifications in splenic architecture - with germinal center hyperplasia and a suppressed humoral immune response - in mice that had been exposed to vanadium agents via inhalation. This paper reports a decrease in the presence of the CD11c surface marker on mouse thymic dendritic cells (DC) as a result of host exposure to vanadium (here, in the form of vanadium pentoxide; V(2)O(5)) over a period of 4 weeks. All results were obtained using immunohistochemistry and flow cytometry. It is surmised that this decrease might induce a dysfunction, including possible negative selection of T-cells, which could increase the presence of autoreactive clones in the exposed host. Such an outcome could, in turn, increase the risk for development of autoimmune reactions in different organs specifically, and of autoimmune diseases in general in these V-exposed hosts.

Published
2012