1. Burden of hospital admissions caused by respiratory syncytial virus (RSV) in infants in England: A data linkage modelling study
- Author
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Pia Hardelid, Mehdi Minaji, Rachel Reeves, Fiona Warburton, Nikolaos Panagiotopoulos, and Richard Pebody
- Subjects
Male ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,viruses ,030106 microbiology ,Information Storage and Retrieval ,Respiratory Syncytial Virus Infections ,Logistic regression ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Cost of Illness ,Risk Factors ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Data Linkage ,Models, Statistical ,Clinical Laboratory Techniques ,business.industry ,Birth Month ,Infant, Newborn ,Infant ,medicine.disease ,Hospitalization ,Vaccination ,Pneumonia ,Logistic Models ,Infectious Diseases ,Respiratory syncytial virus (RSV) ,England ,Bronchiolitis ,Respiratory Syncytial Virus, Human ,Emergency medicine ,Female ,business - Abstract
Current national estimates of respiratory syncytial virus (RSV)-associated hospital admissions are insufficiently detailed to determine optimal vaccination strategies for RSV. We employ novel methodology to estimate the burden of RSV-associated hospital admissions in infants in England, with detailed stratification by patient and clinical characteristics.We used linked, routinely collected laboratory and hospital data to identify laboratory-confirmed RSV-positive and RSV-negative respiratory hospital admissions in infants in England, then generate a predictive logistic regression model for RSV-associated admissions. We applied this model to all respiratory hospital admissions in infants in England, to estimate the national burden of RSV-associated admissions by calendar week, age in weeks and months, clinical risk group and birth month.We estimated an annual average of 20,359 (95% CI 19,236-22,028) RSV-associated admissions in infants in England from mid-2010 to mid-2012. These admissions accounted for 57,907 (95% CI 55,391-61,637) annual bed days. 55% of RSV-associated bed days and 45% of RSV-associated admissions were in infants3 months old. RSV-associated admissions peaked in infants aged 6 weeks, and those born September to November.We employed novel methodology using linked datasets to produce detailed estimates of RSV-associated admissions in infants. Our results provide essential baseline epidemiological data to inform future vaccine policy.
- Published
- 2019