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Introduction: Cutaneous leishmaniasis is an infectious disease transmitted by phlebotomine sandflies and is considered a great environmental and public health problem. Thus, this work presents initial results of the analyses about the relationship between the spatial distribution of this disease and its environmental risk factors in three municipalities, in the state of Pará, Brazil, from 2012 to 2016., Methodology: It was used data from the Ministry of Health, the National Institute for Space Research and the Brazilian Institute of Geography and Statistics. The statistical and spacial analysis of the variables were done using G-test goodness-of-fit, kernel interpolation technique and the Bivariate Global Moran Index (I)., Results: The analyses showed that the most affected individuals were males, adults, low schooling, residents in rural areas and small farmers. The disease spatial distribution was not homogeneous in the municipalities and it was associated to different relationships between the land use and occupation and the notificated cases density, with direct spatial autocorrelation., Conclusions: The deforestation was the most significant risk factor linked to the cases occurrence in all the studied area. We emphasize the need of intensification of epidemiological and environmental surveillance actions in the studied areas., Competing Interests: No Conflict of Interest is declared, (Copyright (c) 2019 Nelson Veiga Goncalves, Claudia do Socorro Carvalho Miranda, Rodrigo Junior Farias da Costa, Juan Andrade Guedes, Erica Silva de Souza Matsumura, Simone Beverly Nascimento da Costa, Selma Kazumi da Trindade Noguchi, Luis Henrique Rocha Guimaraes, Rafael Aleixo Coelho de Oliveira, Livia Simone Alves Tavares, Vera Regina da Cunha Menezes Palacios, Marilia Brasil Xavier.)