Summarizes papers presented at the United States National Institute of Diabetes and Digestive and Kidney Diseases' 'HIV-Infection, Mucosal Immunity, and Pathogenesis' symposium in Bethesda, Maryland on September 11 to 13, 1997. Magnitude of the AIDS epidemic; Importance of tissues in viral replication; Factors that may be related to increases in the levels of HIV-1 in genital secretions in women.
Comments on G. Boivin, J. Handfield, E. Toma, R. Lalonde and M.G. Bergeron's paper on the detection of cytomegalovirus late antigen in peripheral blood leucocytes (PBL) of patients with HIV-associated lymphoma. Correlation of antigenemia and viremia with cytomegalovirus disease; Shell vial assay; Total number of positive cells/150,000 PBL.
A letter to the editor is presented in response to the paper "Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection in Rakai, Uganda," by M.J. Wawer, R.H. Gray, and N.K. Sewankambo in a 2005 issue.
The article comments on the paper "Early Virologic Nonresponse to Tenofovir, Abacavir, and Lamivudine in HIV-Infected Antiretroviral-Naive Subjects," by J.E. Gallant, A.E. Rodriguez, and W.G. Weinberg, published in the December 2005 issue of the Journal of Infectious Diseases. The researchers randomized 340 treatment-naive subjects to receive once-daily tenofovir disoproxil fumarate (DF)/abacavir/lamivudine or efavirenz/abacavir/lamivudine. The signature tenofovir DF resistance mutation was found in samples from more than one-half of subjects tested at the time of virologic failure.