1. Massive Mobilization of Dendritic Cells During Influenza A Virus Subtype H5N1 Infection of Nonhuman Primates.
- Author
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Soloff, Adam C., Bissel, Stephanie J., Junecko, Beth Fallert, Giles, Brendan M., Reinhart, Todd A., Ross, Ted M., and Barratt-Boyes, Simon M.
- Subjects
INFLUENZA A virus, H5N1 subtype ,AVIAN influenza epidemiology ,DENDRITIC cells ,IMMUNE response ,APOPTOSIS ,LYMPH nodes ,LABORATORY monkeys - Abstract
Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macrophage infiltration in lungs was also detected, together with expression of CXCL10. This degree of DC mobilization is unprecedented in viral infection and suggests a potential role for DCs in the pathogenesis of highly pathogenic avian influenza virus. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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