1. Genetic Profiling of Plasmodium ovale wallikeri Relapses With Microsatellite Markers and Whole-Genome Sequencing.
- Author
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Joste, Valentin, Colard-Itté, Emma, Guillochon, Émilie, Ariey, Frédéric, Coppée, Romain, Clain, Jérôme, Houzé, Sandrine, and Group, for the French National Reference Center for Imported Malaria Study
- Subjects
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NUCLEOTIDE sequencing , *MICROSATELLITE repeats , *PLASMODIUM , *PLASMODIUM vivax , *INFECTION , *VARICELLA-zoster virus - Abstract
Like Plasmodium vivax , both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitemia originating from liver-dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of 8 highly polymorphic microsatellite markers, we genotyped 15 P ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the 4 relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P ovale spp. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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