1. HIV-1 Infection Impairs Regulatory T-Cell Suppressive Capacity on a Per-Cell Basis.
- Author
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Angin, Mathieu, Sharma, Siddhartha, King, Melanie, Murooka, Thomas T., Ghebremichael, Musie, Mempel, Thorsten R., Walker, Bruce D., Bhasin, Manoj K., and Addo, Marylyn M.
- Subjects
HIV ,HIV-1 glycoprotein 120 ,T cells ,GENE expression ,PATHOGENICITY of enteroviruses - Abstract
The impact of CD4+ regulatory T cells (Tregs) on human immunodeficiency virus type 1 (HIV-1) pathogenesis remains incompletely understood. Although it has been shown that Tregs can be infected with HIV-1, the consequences of infection on a per-cell basis are still unknown. In vitro HIV-GFP infected and noninfected Tregs were isolated by flow-based cell-sorting to investigate Treg suppressive capacity and gene expression profiles. Our data show that HIV-1-infected Tregs were significantly less suppressive than noninfected Tregs and demonstrated down-regulation of genes critical to Treg function. This impaired function may have detrimental consequences for the control of generalized immune activation and accelerate HIV disease progression. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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